DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6763 and mep1a.2

DIOPT Version :9

Sequence 1:	NP_001262871.1	Gene:	CG6763 / 42754	FlyBaseID:	FBgn0039069	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_001122199.1	Gene:	mep1a.2 / 565535	ZFINID:	ZDB-GENE-041001-208	Length:	689	Species:	Danio rerio

Alignment Length:	307	Identity:	91/307 - (29%)
Similarity:	135/307 - (43%)	Gaps:	66/307 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LKVFLVLALALSSCQALPYVSYDDVDDTEVIELPGNGIEEIPPTLGKDIIDLTPLGTALFGKPDE 67
            :.:|.|| |||.:| |||....:|.|..|               |.:||:
Zfish     7 ISLFFVL-LALKAC-ALPAQYGEDADAGE---------------LREDIL--------------- 39

  Fly    68 ELTANRVGNFSADADEMNPEELGSYLEGDML-VPQTDLIMKNGLPTQSSRW--PNGVVPYEIRGN 129
                           |:|.:......|||:. .|:     :|.:..:.:||  |   :||.:...
Zfish    40 ---------------EINLDSQRELFEGDIAGDPR-----RNAIIDEKARWQFP---IPYILTDT 81

  Fly   130 FNARDMATIENAIGEYHRRTCIRFVKRSSERDYISIRGDNSGCWSSVGRVGGKQEVNLQSPGCLS 194
            .:......|..|:..|..::|:.|.....|..|||.. ...||||.||.:...|.|:: ...|.:
Zfish    82 LDLNAKGVILQALEMYRLKSCVDFKPYEGESTYISFT-KLDGCWSFVGDLKTGQNVSI-GERCDT 144

  Fly   195 RPGTAMHELMHALGFLHEQNRMERDGYVAIQYNNVQSSAMNNFEKAAR---TEAFGVPYDYGSVM 256
            : ....|||:|||||.|||:|.:||.||.|.::.:.....:||.|...   |: ...||||.|:|
Zfish   145 K-AIVEHELLHALGFYHEQSRSDRDDYVKIWWDQIIEGKEHNFNKYEDDFITD-LNTPYDYESIM 207

  Fly   257 HYSKNAFSINGQ-PTILAMQANGADKMGQRNGFSDYDIQKLNRMYDC 302
            ||...:|:.:.. |||........:.:|||..||..|:::|||||:|
Zfish   208 HYRPLSFNKDPDIPTITTTIPAFNNIIGQRLDFSALDLERLNRMYEC 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6763	NP_001262871.1	Astacin	116..304	CDD:279708	68/193 (35%)
CG6763	NP_001262871.1	ZnMc_astacin_like	119..300	CDD:239807	62/184 (34%)
mep1a.2	NP_001122199.1	ZnMc	26..254	CDD:294052	80/284 (28%)
		Astacin	68..256	CDD:279708	68/194 (35%)
		MAM	259..423	CDD:214533
		MAM	264..423	CDD:99706
		MATH	423..579	CDD:295307
		EGF	619..653	CDD:278437
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25214
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X245
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910