DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6763 and Nrx-1

DIOPT Version :9

Sequence 1:	NP_001262871.1	Gene:	CG6763 / 42754	FlyBaseID:	FBgn0039069	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_001262840.1	Gene:	Nrx-1 / 42646	FlyBaseID:	FBgn0038975	Length:	1847	Species:	Drosophila melanogaster

Alignment Length:	346	Identity:	74/346 - (21%)
Similarity:	124/346 - (35%)	Gaps:	99/346 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VDDT-EVIELPGNGIE-EIPPTL-----GKDIIDLTPLGTALFGKPDEELTANRVGNF-----SA 79
            |||: |:|.|.||.:. |:...|     .||:....|..           .::|.| |     |.
  Fly  1082 VDDSFEIISLTGNNMHLELAGILYIGGVFKDMYSKLPAS-----------ISSRSG-FEGCLASL 1134

  Fly    80 DADEMNPEELGSYLEGDMLVPQTDLIMKNGLPTQSSRWPNGVVPYEIRGNFNARDMATIENAIGE 144
            |..:.:|.     |..|.:||.:.::.....||:.|:              ||  .|...|.:.:
  Fly  1135 DLGDASPS-----LTSDAVVPSSLVVSGCEGPTKCSQ--------------NA--CANRGNCVQQ 1178

  Fly   145 YHRRTCIRFVKRSSERDYISIRGDNSGCW-SSVGRVGGKQEVNLQSPGCLSRPGTAMHELMH--- 205
            ::...|        |.|..|..|..  |: .|:....|..:..:|    .:.|..|..:...
  Fly  1179 WNAYAC--------ECDMTSYTGPT--CYDESIAYEFGNNKGMVQ----YTFPENAQADTEEDNI 1229

  Fly   206 ALGFLHEQNRMERDGYVAIQYNNVQSSAMNNFEKAARTEA--FGVPYDYGSV--------MHYSK 260
            ||||:     ..|...|.::   |:|:...::.:....|.  |.| |:.|||        ...:.
  Fly  1230 ALGFI-----TTRPDAVLLR---VESATTQDYMELEIVEGNIFMV-YNIGSVDLPLGEIGTKVND 1285

  Fly   261 NAFSINGQPTILAMQANGADKMGQRNGFSDYDIQKLNRMYDCGTV-NAVPVAPGLPAPAPAPGAP 324
            ||:.      ::..|..|.:...|   ..||::|.|.......|| |.:       :.....|..
  Fly  1286 NAYH------VVRFQRKGGNATLQ---LDDYNVQALTPQSHHSTVFNTM-------SNVQVGGKF 1334

  Fly   325 AGSGNPIVDSFIGGLISGLGL 345
            :.:|...::....|:|:||.:
  Fly  1335 SRNGRNRIERPFAGVIAGLSV 1355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6763	NP_001262871.1	Astacin	116..304	CDD:279708	39/201 (19%)
CG6763	NP_001262871.1	ZnMc_astacin_like	119..300	CDD:239807	39/194 (20%)
Nrx-1	NP_001262840.1	LamG	110..263	CDD:238058
		EGF_CA	311..347	CDD:238011
		Laminin_G_2	386..517	CDD:280389
		LamG	555..716	CDD:238058
		EGF	746..777	CDD:278437
		Laminin_G_2	814..945	CDD:280389
		LamG	988..1136	CDD:238058	17/65 (26%)
		EGF	1164..1195	CDD:278437	10/54 (19%)
		Laminin_G_2	1233..1356	CDD:280389	30/148 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444948
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930