DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6763 and MEP1A

DIOPT Version :9

Sequence 1:	NP_001262871.1	Gene:	CG6763 / 42754	FlyBaseID:	FBgn0039069	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	XP_011512930.1	Gene:	MEP1A / 4224	HGNCID:	7015	Length:	774	Species:	Homo sapiens

Alignment Length:	250	Identity:	82/250 - (32%)
Similarity:	124/250 - (49%)	Gaps:	18/250 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 PDEELTANRVGNFSADADEMNPEELGSYLEGDMLVPQTDLIMKNGLPTQSSRW--PNGVVPYEIR 127
            |:|.:.....|. ..|..|:|........:||:|:.::    :|||...::||  |   :||.:.
Human    56 PEENVHDADFGE-QKDISEINLAAGLDLFQGDILLQKS----RNGLRDPNTRWTFP---IPYILA 112

  Fly   128 GNFNARDMATIENAIGEYHRRTCIRFVKRSSERDYISIRGDNSGCWSSVGRVGGKQEVNLQSPGC 192
            .|........|..|...:..::|:.|.....|..|| |.....||||.||.....|.::: ..||
Human   113 DNLGLNAKGAILYAFEMFRLKSCVDFKPYEGESSYI-IFQQFDGCWSEVGDQHVGQNISI-GQGC 175

  Fly   193 LSRPGTAMHELMHALGFLHEQNRMERDGYVAIQYNNVQSSAMNNF---EKAARTEAFGVPYDYGS 254
            ..: ....||::|||||.|||:|.:||.||.|.::.:.|...:||   :.:..|: ...||||.|
Human   176 AYK-AIIEHEILHALGFYHEQSRTDRDDYVNIWWDQILSGYQHNFDTYDDSLITD-LNTPYDYES 238

  Fly   255 VMHYSKNAFSINGQ-PTILAMQANGADKMGQRNGFSDYDIQKLNRMYDCGTVNAV 308
            :|||...:|:.|.. |||.|........:|||..||..|:::|||||:|.|.:.:
Human   239 LMHYQPFSFNKNASVPTITAKIPEFNSIIGQRLDFSAIDLERLNRMYNCTTTHTL 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6763	NP_001262871.1	Astacin	116..304	CDD:279708	69/193 (36%)
CG6763	NP_001262871.1	ZnMc_astacin_like	119..300	CDD:239807	63/184 (34%)
MEP1A	XP_011512930.1	ZnMc_meprin	58..287	CDD:239809	79/240 (33%)
		Astacin	101..289	CDD:279708	69/194 (36%)
		MAM	292..459	CDD:214533	0/1 (0%)
		MAM	297..459	CDD:99706
		MATH_Meprin_Alpha	459..622	CDD:239752
		EGF_CA	700..738	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I4542
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8634
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X245
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.910