DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6763 and nas-14

DIOPT Version :9

Sequence 1:	NP_001262871.1	Gene:	CG6763 / 42754	FlyBaseID:	FBgn0039069	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_502533.2	Gene:	nas-14 / 184247	WormBaseID:	WBGene00003533	Length:	503	Species:	Caenorhabditis elegans

Alignment Length:	260	Identity:	99/260 - (38%)
Similarity:	140/260 - (53%)	Gaps:	18/260 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 TALFGKPDEELTANRVGNFSADAD-----EMNPEELGSYLEGDMLVPQTDLIMK------NGLPT 112
            ||...||.:....:...:...:.|     |:...::...|..|.|:.:.::..|      |.:..
Worm    56 TAPVKKPTDAEIESMQNSLLFEGDIMGVPEIEKSDILKRLRDDPLLDEDEIFRKPFHSALNLVTY 120

  Fly   113 QSSRWPNGVVPYEIRGNFNARDMATIENAIGEYHRRTCIRFV-KRSSERDYISIRGDNS-GCWSS 175
            ....||.|.|||.:...........|..|..||..:||:||| |...:.|||.::.:.: ||.|.
Worm   121 PDKLWPEGQVPYMLEEGMTNDQRTAIAQAFDEYKTKTCVRFVPKTDDDFDYIYVKRNVAFGCSSY 185

  Fly   176 VGRVGGKQEVNLQSPGCLSRPGTAMHELMHALGFLHEQNRMERDGYVAIQYNNVQSSAMNNFEKA 240
            |||.||.|.|:|:...|.|: |...|||||||||.||.:|.:||.:|.|..:|::...|.||||.
Worm   186 VGRAGGNQTVSLEVDKCFSK-GIIAHELMHALGFFHEHSRTDRDDFVDINEDNIRPGMMRNFEKY 249

  Fly   241 AR--TEAFGVPYDYGSVMHYSKNAFSINGQPTILAMQANGADKMGQRNGFSDYDIQKLNRMYDCG 303
            .|  .::.|:||||.|||||.|.|||.||:|||:. :.|.|| :|||...|:.|.:|:|::|.||
Worm   250 PRKIIDSLGMPYDYESVMHYHKLAFSRNGKPTIIP-KDNEAD-VGQRYKLSEMDSKKVNKLYQCG 312

Fly 304 303
Worm 313 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6763	NP_001262871.1	Astacin	116..304	CDD:279708	88/192 (46%)
CG6763	NP_001262871.1	ZnMc_astacin_like	119..300	CDD:239807	83/184 (45%)
nas-14	NP_502533.2	Astacin	123..313	CDD:279708	88/193 (46%)
		ZnMc_astacin_like	128..309	CDD:239807	83/183 (45%)
		ShKT	380..414	CDD:214586
		ShK	468..503	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D472790at33208
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	1	1.000	-	-		mtm4830
orthoMCL	1	0.900	-	-		OOG6_101406
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.680