DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6763 and nas-8

DIOPT Version :9

Sequence 1:	NP_001262871.1	Gene:	CG6763 / 42754	FlyBaseID:	FBgn0039069	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_501114.2	Gene:	nas-8 / 183207	WormBaseID:	WBGene00003527	Length:	403	Species:	Caenorhabditis elegans

Alignment Length:	326	Identity:	115/326 - (35%)
Similarity:	171/326 - (52%)	Gaps:	54/326 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 VIELPGNGIEE--IPPTLGKD--IID---LTPLGTALFGKPDEELTANRVGNFSADADEMNPEEL 89
            ||.:|....|:  :||:...:  :.|   |.||.       |:|       .|..:.|..|.|:|
Worm    22 VIIIPIYAAEKDLLPPSTSSETFLTDEDFLRPLN-------DDE-------TFLTEKDFKNGEKL 72

  Fly    90 GS-------------YLEGDM-------LVPQ-TDLIMKNGLPTQSSRWPNGVVPYEIRGNFNAR 133
            |.             |.:||:       |.|: ::.:.:||:.|.:.:||||.:||.|...:|.|
Worm    73 GEDHVPAGSILWKQVYKKGDIRGKAAWKLDPKNSESLRRNGVITGTRKWPNGRIPYVISNQYNDR 137

  Fly   134 DMATIENAIGEYHRRTCIRFVKRSS-ERDYISIRGDNSGCWSSVGRVGGKQEVNLQSPGCLSRPG 197
            :.|.:..:...||.:||:|||.|:: :.||:.| |...||:|.|||.||:||::|.: ||| :..
Worm   138 ERAVLARSFQAYHDKTCVRFVPRTAVDNDYLYI-GKIDGCYSDVGRAGGRQELSLDN-GCL-QYD 199

  Fly   198 TAMHELMHALGFLHEQNRMERDGYVAIQYNNVQSSAMNNFEKA--ARTEAFGVPYDYGSVMHYSK 260
            ||:|||||::||.||..|.:||.::.|.::|:...|.:.|.|.  |.:..:|..|||.|:|||..
Worm   200 TAIHELMHSVGFYHEHERWDRDEHITILWHNIDREAYDQFGKVDLAESSYYGQLYDYYSIMHYDS 264

  Fly   261 NAFSINGQPTILAMQANGADKMGQRNGFSDYDIQKLNRMYDCGTVNAVPVAPG------LPAPAP 319
            .|||.||..|::|.|:.....:|....||..||.|:|.||.|..|...|...|      :|.|||
Worm   265 LAFSKNGFETMVAKQSEMTAVIGAAIDFSPIDILKMNLMYQCSDVKLPPTVVGTTDKTIVPVPAP 329

  Fly   320 A 320
            :
Worm   330 S 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6763	NP_001262871.1	Astacin	116..304	CDD:279708	82/190 (43%)
CG6763	NP_001262871.1	ZnMc_astacin_like	119..300	CDD:239807	77/183 (42%)
nas-8	NP_501114.2	Astacin	119..308	CDD:279708	82/191 (43%)
		ZnMc_astacin_like	123..304	CDD:239807	77/183 (42%)
		ShK	337..372	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	170	1.000	Domainoid score	I2268
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D472790at33208
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	1	1.000	-	-		mtm4854
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X245
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.920