DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6763 and dpy-31

DIOPT Version :9

Sequence 1:	NP_001262871.1	Gene:	CG6763 / 42754	FlyBaseID:	FBgn0039069	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_001022731.1	Gene:	dpy-31 / 176014	WormBaseID:	WBGene00006592	Length:	592	Species:	Caenorhabditis elegans

Alignment Length:	389	Identity:	106/389 - (27%)
Similarity:	164/389 - (42%)	Gaps:	89/389 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KVFLVLALALSSCQALPYVSYDDVDDTEVIELPGNGIEEIPPTLGKDIIDLTPLGTALFGKPDEE 68
            |:|::..| ||.|.|   .|..|:.:.:         ||.||:....:     ....:..:.|::
Worm     3 KIFIIFGL-LSLCAA---HSLRDLSNKD---------EEDPPSSAPGV-----RKRRMMSEEDQK 49

  Fly    69 LTANRVGNFSADADE------------------------MNPEELGSYLEGD-MLVPQ------- 101
            .....:...:..|||                        :||||.|.:.:|| :|.|:
Worm    50 TVDYYMDKLNKLADEKHPEEIERHKNPELVAWDRKRDSVLNPEEQGKFFQGDIVLYPEQAKALYE 114

  Fly   102 ------TDLIMKNGLPTQSSRW-PNGVVPYEIRGNFNARDMATIENAIGEYHRRTCIRFVK---- 155
                  ...:.:..:.:...|| .:..:.|...|:...|:...||.|:..:|..||:.|.:
Worm   115 QALTEGKTRVKRKFIGSNLRRWDASRPIIYAFDGSHTQREQRIIELALEHWHNITCLNFQRNDQA 179

  Fly   156 RSSERDYISIRGDNSGCWSSVGR--VGGKQEVNLQSPGCLSRPGTAMHELMHALGFLHEQNRMER 218
            .|..|...:   |..||.|:|||  :|.:|.|:| :|.|: |.|...||:.|||||.|||:|.:|
Worm   180 NSGNRIVFT---DVDGCASNVGRHPLGEEQLVSL-APECI-RLGVIAHEVAHALGFWHEQSRPDR 239

  Fly   219 DGYVAIQYNNVQSSAMNNF--EKAARTEAFGVPYDYGSVMHYSKNAFS-INGQPTILAMQANGAD 280
            |.||.:::.|:...:...|  |.....:..||||||||:|||...||| .:...||.....:...
Worm   240 DQYVTVRWENIDKDSKGQFLKEDPDDVDNAGVPYDYGSIMHYRSKAFSKFDDLYTISTYVTDYQK 304

  Fly   281 KMGQRNGFSDYDIQKLNRMYDCGTVNAVPVAPGLPAPAPAPGAPAGSGNP-------IVDSFIG 337
            .:|||:..|..||:.:|::| |..|          .|:..|....|..:|       ..|.|.|
Worm   305 TIGQRDQLSFNDIRLMNKIY-CSAV----------CPSKLPCQRGGYTDPRRCDRCRCPDGFTG 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6763	NP_001262871.1	Astacin	116..304	CDD:279708	72/197 (37%)
CG6763	NP_001262871.1	ZnMc_astacin_like	119..300	CDD:239807	68/189 (36%)
dpy-31	NP_001022731.1	Astacin	134..327	CDD:279708	72/198 (36%)
		ZnMc_astacin_like	139..324	CDD:239807	68/189 (36%)
		CUB	383..483	CDD:214483
		TSP1	493..539	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681837at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020