DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6763 and toh-1

DIOPT Version :9

Sequence 1:	NP_001262871.1	Gene:	CG6763 / 42754	FlyBaseID:	FBgn0039069	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_497769.3	Gene:	toh-1 / 175491	WormBaseID:	WBGene00006591	Length:	414	Species:	Caenorhabditis elegans

Alignment Length:	237	Identity:	73/237 - (30%)
Similarity:	113/237 - (47%)	Gaps:	32/237 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 WPNGVVPYEI-RGNFNARDMATIENAIGEYHRRTCIRFVKRSSERD---YISIRGDNSGCWSS-V 176
            |.:..:|::| .|::|.:.:  |...|..:...||:||.:....||   |:..:||:  |::. :
Worm    71 WNSYEIPFQIWGGDYNFQSL--IRRGIRMWEDSTCLRFKENQQSRDAIRYVLEKGDS--CFTEYI 131

  Fly   177 GRVGGKQEVNLQSPGCLSRPGTAMHELMHALGFLHEQNRMERDGYVAIQYNNVQSSAMNNFEK-A 240
            ||.||.|::.:.|. |......| ||..|||||.|...|.:||.:::|.:.||...|..:|.. .
Worm   132 GRNGGHQDIIIGSE-CAEEYVVA-HETGHALGFWHTHQRPDRDRHISINWKNVMEEATASFMPFR 194

  Fly   241 ARTEAFG--------VPYDYGSVMHYSKNAFSIN-GQPTILAMQANGADKMG-QRNGFSDYDIQK 295
            :..:|||        |||||||:|||...|.::. ...||:..:......|| ::..|.|..:
Worm   195 SMLQAFGIRQVSPRRVPYDYGSLMHYHAVAHAVKVSDFTIVPKELKYVTTMGTEKMAFLDAKV-- 257

  Fly   296 LNRMYDC-----GTVNAVPVAPGLPAP--APAPGAPAGSGNP 330
            :|.:| |     |..:...:|.|.|.|  ......|.|.|.|
Worm   258 INDIY-CPNACQGRNHLNCLAGGYPDPNNCNVCRCPEGLGGP 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6763	NP_001262871.1	Astacin	116..304	CDD:279708	64/207 (31%)
CG6763	NP_001262871.1	ZnMc_astacin_like	119..300	CDD:239807	61/196 (31%)
toh-1	NP_497769.3	Astacin	71..265	CDD:279708	64/202 (32%)
		ZnMc_astacin_like	73..262	CDD:239807	61/196 (31%)
		CUB	320..410	CDD:214483
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681837at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820