DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc16 and APC6

DIOPT Version :9

Sequence 1:	NP_477397.1	Gene:	Cdc16 / 42753	FlyBaseID:	FBgn0025781	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_565188.1	Gene:	APC6 / 844213	AraportID:	AT1G78770	Length:	543	Species:	Arabidopsis thaliana

Alignment Length:	654	Identity:	203/654 - (31%)
Similarity:	308/654 - (47%)	Gaps:	129/654 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RQLVKQFIDMRRYSTALFWAEKVAVLGGLEPRDIYYQAQCMYLLGEYHRAAHTIQHHKLEKNSLP 87
            |.:|:..:....||:|:|:|:|||.|.. :|.|||.|||.::|...|.||.|.:...|:....|.
plant    10 RGVVRDCVSKHLYSSAIFFADKVAALTN-DPSDIYMQAQALFLGRHYRRAFHLLNASKIVLRDLR 73

  Fly    88 CFNLLLESLYAAKEFTEAANVIQNVEVEVMTTSLINQPVDASSGCYLESNSVFGGEENHRNELLS 152
            ...|..:.|...||:.:...::.:.:|:  ...::   .||..|..::.:.  .||:...| :.|
plant    74 FRYLAAKCLEELKEWDQCLLMLGDAKVD--DDGIV---YDAKDGNVIDFDK--DGEDREIN-ISS 130

  Fly   153 SIYLMKGKVYEALDNRGMAMDFYVQALHKSIYCFEALEALVQHEMLMAWEEFELMHHLPLAQQSS 217
            :|..::||.|.||.||..|..:|..|:.....|:||||.|::..||.:.||..|:..|    |.|
plant   131 AICFLRGKAYGALQNRSQARQWYKAAIKADPLCYEALECLIESHMLTSEEESSLLSSL----QFS 191

  Fly   218 EADAKFILKLYESRLKKYYELISARNAEEMSPIVNPDILQFIKEFTARVQQSGSSDTQMPKVSAV 282
            ..|. ::...|...:|||                                         .|.|.|
plant   192 PEDG-WLSSFYSCLIKKY-----------------------------------------DKESTV 214

  Fly   283 KVPLTPSQFMSPAQKVLEDLKAPTFSLQTSLSKASSLIDASHRSMFDSSSRRRSRDHDTDTLIPI 347
            ::..          |.||:        :||.|.:.|                        ::|.:
plant   215 ELKF----------KKLEN--------ETSGSVSGS------------------------SMITL 237

  Fly   348 AECLDRVQRSTDLMAAEAEKCFYDCDYKQCLKILNELLKVDPFHNTALTIQIACLVENGDFNRLF 412
            |       .:|||:|.:||.....|:|::|.::...||:.||||.....:.:|..:|.|:.|.|:
plant   238 A-------NNTDLLACKAEYYHQCCEYQKCFELTAALLEKDPFHLKCTLVHLAAAMELGNSNELY 295

  Fly   413 YVAHKLVDRYPDKAISWYAVGCYYDMIGKSDPARRYLSKATALDRLYGPAWLAYGHSFANENEHE 477
            .:|..||..||.||:||:||||||..|.|...||||.||||.:|..:.||.:.||:|||.:.|.:
plant   296 LMACNLVKDYPSKALSWFAVGCYYYCIKKYAEARRYFSKATGIDGSFSPARIGYGNSFAAQEEGD 360

  Fly   478 QAMAAYFKATQLMRGCHLPLLYIGVECGLTKNLELAEKFFLQAMNIAPLDVYVLHELGVIKYEYE 542
            |||:||..|.:|..|||||.||||:|...|.:.:||::||:||..|.|.|..|.:||||:.|..:
plant   361 QAMSAYRTAARLFPGCHLPTLYIGMEYMRTHSYKLADQFFMQAKAICPSDPLVYNELGVVAYHMK 425

  Fly   543 FFDGAATIFQCTVDIVKQRAKSNNEEISSRWEPLFINLGHSLRKVHKYEEALYNFQYALLLKPQS 607
            .:..|...|:.|:..:.       ..::..|||..:||.|:.||:.|..||:..::.||.|..:|
plant   426 EYGKAVRWFEKTLAHIP-------SALTESWEPTVVNLAHAYRKLRKDREAISYYERALTLSTKS 483

  Fly   608 PTTYTSIGFIHALLGNLDPAIEAFHKSLALNRDCIVTSTILKSCIEDLMDDSATIDEICSAALRD 672
            .:||:.:.:.:.|.||...||..:||:|.|..|                |...|  |:.:.||.|
plant   484 LSTYSGLAYTYHLQGNFSAAISYYHKALWLKPD----------------DQFCT--EMLNVALMD 530

  Fly   673 VAKN 676
            ..:|
plant   531 ECQN 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc16	NP_477397.1	ANAPC3	31..112	CDD:289650	27/80 (34%)
		TPR_11	425..489	CDD:290150	35/63 (56%)
		TPR repeat	426..454	CDD:276809	18/27 (67%)
		TPR repeat	462..488	CDD:276809	13/25 (52%)
		TPR repeat	493..523	CDD:276809	16/29 (55%)
		TPR repeat	528..552	CDD:276809	7/23 (30%)
		TPR_11	576..638	CDD:290150	22/61 (36%)
		TPR repeat	576..602	CDD:276809	9/25 (36%)
		TPR repeat	607..637	CDD:276809	11/29 (38%)
APC6	NP_565188.1	ANAPC3	19..98	CDD:403946	27/79 (34%)
		TPR repeat	309..337	CDD:276809	18/27 (67%)
		PEP_TPR_lipo	<323..>518	CDD:274350	81/217 (37%)
		TPR repeat	345..371	CDD:276809	13/25 (52%)
		TPR repeat	381..405	CDD:276809	12/23 (52%)
		TPR repeat	411..439	CDD:276809	9/27 (33%)
		TPR repeat	445..479	CDD:276809	13/33 (39%)
		TPR repeat	484..511	CDD:276809	9/26 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	91	1.000	Domainoid score	I2646
eggNOG	1	0.900	-	-		E1_KOG1173
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2899
Inparanoid	1	1.050	315	1.000	Inparanoid score	I724
OMA	1	1.010	-	-		QHG56718
OrthoDB	1	1.010	-	-		D905026at2759
OrthoFinder	1	1.000	-	-		FOG0004793
OrthoInspector	1	1.000	-	-		oto3788
orthoMCL	1	0.900	-	-		OOG6_102501
Panther	1	1.100	-	-	LDO	PTHR12558
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3945
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840