DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc16 and Cdc16

DIOPT Version :9

Sequence 1:	NP_477397.1	Gene:	Cdc16 / 42753	FlyBaseID:	FBgn0025781	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_081552.2	Gene:	Cdc16 / 69957	MGIID:	1917207	Length:	620	Species:	Mus musculus

Alignment Length:	728	Identity:	266/728 - (36%)
Similarity:	391/728 - (53%)	Gaps:	143/728 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 IDLALYRQLVKQFIDMRRYSTALFWAEKVAVLGGLEPRDIYYQAQCMYLLGEYHRAAHTIQHHKL 81
            ::|...|:.|:|::|.::|.:|||||:|||.|...||:|:|:.|||:||..:||||||.::..||
Mouse     1 MNLEPLRKRVRQYLDQQQYQSALFWADKVASLSHEEPQDVYWLAQCLYLTAQYHRAAHALRSRKL 65

  Fly    82 EKNSLPCFNLLLESLYAAKEFTEAANVIQNVEVEVMTTSLINQPVDASSGCYLESNSVFGGEENH 146
            :|....|..|.....|||||..:|.::: ::| |.:...|..:.:...:|    |.......|..
Mouse    66 DKLYEACRYLAARCHYAAKEHQQALDIL-DME-EPINRRLFEKYLKDDNG----SRDPSSDWEMS 124

  Fly   147 RNELLSSIYLMKGKVYEALDNRGMAMDFYVQALHKSIYCFEALEALVQHEMLMAWEEFELMHHLP 211
            ::.:.|||.|::||:|:|||||.:|...|.:||...:|||||.:.|..|.||.|.||.||:..||
Mouse   125 QSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKELLDSLP 189

  Fly   212 LAQQSSEADAKFILKLYESRLKKYYELISARNAEEMSPIVNPDILQFIKEFTARVQQSGSSDTQM 276
            |.:..:| :.:.:..::|::||||.:
Mouse   190 LNKLCAE-EQELLRFVFENKLKKYNK--------------------------------------- 214

  Fly   277 PKVSAVKVPLTPSQFMSPAQKVLEDLKAPTFSLQTSLSKASSLIDASHRSMFDSSSRRRSRDHDT 341
                       ||
Mouse   215 -----------PS---------------------------------------------------- 216

  Fly   342 DTLIPIAECLDRVQRSTDLMAAEAEKCFYDCDYKQCLKILNELLKVDPFHNTALTIQIACLVENG 406
            :|:||  |.:|.:|.:.|::.:.||:.:|:||:|.|.|:.:.:::.||||...|.:.|..|||..
Mouse   217 ETVIP--ESVDGLQENLDVVVSLAERHYYNCDFKMCYKLTSTVMEKDPFHANCLPVHIGTLVELN 279

  Fly   407 DFNRLFYVAHKLVDRYPDKAISWYAVGCYYDMIG-KSDPARRYLSKATALDRLYGPAWLAYGHSF 470
            ..|.|||::|||||.||...:||:||||||.|:| |::.|||||||||.|::.|||||:||||||
Mouse   280 KANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSF 344

  Fly   471 ANENEHEQAMAAYFKATQLMRGCHLPLLYIGVECGLTKNLELAEKFFLQAMNIAPLDVYVLHELG 535
            |.|:||:|||||||.|.|||:|||||:||||:|.|||.|.:|||:||.||::|||.|.:|:||:|
Mouse   345 AVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVG 409

  Fly   536 VIKYEYEFFDGAATIFQCTVDIVKQRAKSNNEEISSRWEPLFINLGHSLRKVHKYEEALYNFQYA 600
            |:.::...:..|...|   :|.:::.....||....:||||..||||..||:.||.|||...:.|
Mouse   410 VVAFQNGEWKTAEKWF---LDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQA 471

  Fly   601 LLLKPQSPTTYTSIGFIHALLGNLDPAIEAFHKSLALNRDCIVTSTILKSCIEDLMDDS------ 659
            |:|.||:.:||::||:||:|:||.:.|::.||.:|.|.||...:.|:|..|||..:.||
Mouse   472 LVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGA 536

  Fly   660 ----------------ATIDEICSAA--LRD--VAKNIT--ANSRRVLNSDKFNGMKLKFDEEEE 702
                            .|:..|.|..  .||  |.|..|  |....:.||.|....:...:|..|
Mouse   537 DIKDKLKCYDFDVHTMKTLKNIISPPWDFRDFEVEKQNTEEAGLAPLQNSTKAPESRPNLEETFE 601

  Fly   703 FANSDSNMVVEMS 715
            ...::|:|::|.|
Mouse   602 IEMNESDMMLETS 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc16	NP_477397.1	ANAPC3	31..112	CDD:289650	37/80 (46%)
		TPR_11	425..489	CDD:290150	44/64 (69%)
		TPR repeat	426..454	CDD:276809	19/28 (68%)
		TPR repeat	462..488	CDD:276809	20/25 (80%)
		TPR repeat	493..523	CDD:276809	20/29 (69%)
		TPR repeat	528..552	CDD:276809	6/23 (26%)
		TPR_11	576..638	CDD:290150	30/61 (49%)
		TPR repeat	576..602	CDD:276809	13/25 (52%)
		TPR repeat	607..637	CDD:276809	13/29 (45%)
Cdc16	NP_081552.2	TPR 1	4..33		13/28 (46%)
		ANAPC3	15..94	CDD:289650	37/78 (47%)
		TPR repeat	36..65	CDD:276809	15/28 (54%)
		TPR 2	37..62		14/24 (58%)
		TPR repeat	70..94	CDD:276809	8/23 (35%)
		TPR 3	70..93		8/22 (36%)
		TPR 4	128..159		14/30 (47%)
		TPR 5	164..187		10/22 (45%)
		TPR 6	198..222		6/23 (26%)
		TPR 7	232..260		0/27 (0%)
		TPR 8	267..294		2/26 (8%)
		TPR repeat	298..329	CDD:276809	1/30 (3%)
		TPR 9	299..329		1/29 (3%)
		TPR 10	334..362		9/27 (33%)
		TPR repeat	336..362	CDD:276809	9/25 (36%)
		TPR repeat	367..397	CDD:276809	11/29 (38%)
		TPR 11	369..397		11/27 (41%)
		TPR_11	401..476	CDD:290150	53/75 (71%)
		TPR 12	402..434		20/32 (63%)
		TPR repeat	402..430	CDD:276809	16/28 (57%)
		TPR 13	442..474		24/31 (77%)
		TPR_11	447..509	CDD:290150	44/61 (72%)
		TPR repeat	447..473	CDD:276809	19/25 (76%)
		TPR	448..478	CDD:197478	22/29 (76%)
		TPR repeat	478..508	CDD:276809	19/29 (66%)
		TPR 14	479..508		18/28 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..596		8/18 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837231
Domainoid	1	1.000	251	1.000	Domainoid score	I2092
eggNOG	1	0.900	-	-		E1_KOG1173
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2899
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56718
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004793
OrthoInspector	1	1.000	-	-		oto94915
orthoMCL	1	0.900	-	-		OOG6_102501
Panther	1	1.100	-	-	LDO	PTHR12558
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R265
SonicParanoid	1	1.000	-	-		X3945
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.740