DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc16 and Cdc27

DIOPT Version :9

Sequence 1:	NP_477397.1	Gene:	Cdc16 / 42753	FlyBaseID:	FBgn0025781	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_001261503.1	Gene:	Cdc27 / 38798	FlyBaseID:	FBgn0012058	Length:	900	Species:	Drosophila melanogaster

Alignment Length:	811	Identity:	162/811 - (19%)
Similarity:	278/811 - (34%)	Gaps:	225/811 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LLGEYHRAAHTIQHHKLEKNSLPCFNLLLES--------LYAA----KEFTEAANVI---QNVEV 114
            |||:...||...|.|     |...||....|        |:.|    ::..|..::|   .||..
  Fly   156 LLGQDTDAAAIFQIH-----STDVFNTCQGSSVNANAMVLFGAEQQGQQHQERQSLITNLSNVSN 215

  Fly   115 EVMTTSL--INQPVDASSGCYLESNSVFG-GEENHRNELLSSIYLMKGKVYEALDNRGMAMDFYV 176
            .::||.:  ..|.::.:...:..||.|.. ...|:.|.|.|||.:::|.:.:......|..|..:
  Fly   216 YILTTPVDQQQQQINQNQNQHHNSNMVTPINNNNNNNNLNSSISMLRGGLVQNSSMLAMLEDTPM 280

  Fly   177 QALHKSIYCFEALEALV----------QHEMLMA----WEEFELMHHLPLAQQSSEADAKFI--- 224
            .|.......::..:.|.          |.:.|.|    ...|.:|   ||....:..|..||
  Fly   281 GAPQDPAGQYQQNQQLYDMSSGTPFRKQFKYLSAISPPTPSFGIM---PLTSPCTGNDGSFIGNH 342

  Fly   225 ---------------------LKLYESRLKKYY-ELISARNAEEMSPIVNPDILQFIKEFTARVQ 267
                                 .|:...:||.:. .||:.:......|.|          ||
  Fly   343 TPVMNISYSPMPQMLVEVNQEPKMMGKKLKTHVGGLINRKEGSLNKPAV----------FT---- 393

  Fly   268 QSGSSDTQMPKVSAV------KVPLTP-------SQFMSPAQKVLEDLKAPTF------------ 307
            |:|:...:.|..:.|      .||..|       |:..|.:..|.|:.|:|..
  Fly   394 QAGNITPRTPNNNNVGNNGNMNVPPNPNAAVRRSSRLFSNSYSVKENNKSPNIANKFVQPRSPPR 458

  Fly   308 ---SLQTSLSKASSLI-DASHR--------------SMFDSSSRRRSRDHDTDTLIPIAECLDRV 354
               |..|.:...:.|| |.||.              |..:::|..||...:...|  :...|:..
  Fly   459 KAKSRMTKICLNNELIEDKSHHLSEKRKEKVETITSSGANNNSGGRSAAEEAKVL--LNNSLNNA 521

  Fly   355 Q-----------RSTD-LMA-----AEAEKCF--YDC---------------------------- 372
            |           :|.| |||     |||.:..  :.|
  Fly   522 QTMAHQLMGLKKQSADGLMALLRGLAEAYQLLSNFQCKAAIKQLETTIPKHHLNSSWVQSLIGLA 586

  Fly   373 -----DYKQCLKILNELLKVDPFHNTALTIQIACLVENGDFNRLFYVAHKLVDRYPDKAISWYAV 432
                 :|:..:.|...:.|.:|.....:.|..:.|........|..:|..|:::.....::|...
  Fly   587 RYEMREYEAAVAIFETIHKTEPCRLDYMEIYSSSLWHLQREVELSALAQDLINQDKTSPVTWCVS 651

  Fly   433 GCYYDMIGKSDPARRYLSKATALDRLYGPAWLAYGHSFANENEHEQAMAAYFKATQLMRGCHLPL 497
            |..:.:..:.:.|.::..:|..:|..:..::...||......|.::|| .||:|..:....|...
  Fly   652 GNCFSLQKEHETAIKFFKRAVQVDPDFVYSYTLLGHELVLTEEFDKAM-DYFRAAVVRDPRHYNA 715

  Fly   498 LY-IGVECGLTKNLELAEKFFLQAMNIAPLDVYVLHELGVIKYEYEFFDGAATIFQCTVDIVKQR 561
            .| ||......:..||||..:::|:.|.|.:..:|..:|.:::..:..|       .::..:...
  Fly   716 WYGIGTIYSKQEKYELAEIHYVKALKINPQNSVILVHIGAMQFYMKKKD-------LSLQTLNTA 773

  Fly   562 AKSNNEEISSRWE--PLFINLGHSLRKVHKYEEALYNFQYALLLKPQSPTTYTSIGFIHALLGNL 624
            |..:.:...:|:.  .::.:||       ||:|||...:....:.|:....:..||.||..|||:
  Fly   774 ATLDPKNPLTRFHRGSIYFSLG-------KYQEALRELEELKEVVPKESVVFYLIGKIHKTLGNM 831

  Fly   625 DPAIEAFHKSLALNRDCIVTSTILKSCIEDLMDDSATIDEICSAALRDVAKNITANSRRVLNSDK 689
            |.|:  .|.|.|.:.|....:..:|...:.:...|.     |.|       |.||
  Fly   832 DLAL--MHFSWATDLDPKGANNQIKDAFDSMAHPSC-----CPA-------NTTA---------- 872

  Fly   690 FNGMKLKFDEEEEFANSDSNMVVEM--SFDT 718
                 |..|.|.....||.:...:.  |:|:
  Fly   873 -----LDVDLEPTSERSDDSTQAQQDGSYDS 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc16	NP_477397.1	ANAPC3	31..112	CDD:289650	15/61 (25%)
		TPR_11	425..489	CDD:290150	13/63 (21%)
		TPR repeat	426..454	CDD:276809	4/27 (15%)
		TPR repeat	462..488	CDD:276809	8/25 (32%)
		TPR repeat	493..523	CDD:276809	9/30 (30%)
		TPR repeat	528..552	CDD:276809	3/23 (13%)
		TPR_11	576..638	CDD:290150	20/61 (33%)
		TPR repeat	576..602	CDD:276809	7/25 (28%)
		TPR repeat	607..637	CDD:276809	11/29 (38%)
Cdc27	NP_001261503.1	ANAPC3	16..94	CDD:289650
		TPR_11	67..145	CDD:290150
		TPR repeat	68..104	CDD:276809
		TPR repeat	109..143	CDD:276809
		TPR_12	539..601	CDD:290160	9/61 (15%)
		TPR repeat	582..605	CDD:276809	2/22 (9%)
		TPR	590..850	CDD:223533	59/276 (21%)
		TPR_1	645..678	CDD:278916	5/32 (16%)
		TPR repeat	678..708	CDD:276809	8/30 (27%)
		TPR_1	713..746	CDD:278916	10/32 (31%)
		TPR repeat	713..741	CDD:276809	8/27 (30%)
		TPR repeat	747..773	CDD:276809	3/32 (9%)
		TPR repeat	781..809	CDD:276809	8/34 (24%)
		TPR repeat	815..838	CDD:276809	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449297
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12558
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940