Protein Alignment Cdc16 and Cdc23

DIOPT Version :10

• Sequence 1: NP_477397.1
• Gene: Cdc16 / 42753
• FlyBaseID: FBgn0025781
• Length: 718
• Species: Drosophila melanogaster
• Sequence 2: NP_610036.2
• Gene: Cdc23 / 35315
• FlyBaseID: FBgn0032863
• Length: 678
• Species: Drosophila melanogaster
• Alignment Length: 701
• Identity: 134/701 - (19%)
• Similarity: 228/701 - (32%)
• Gaps: 251/701 - (35%)

  Fly    48 LGGLEPRDI--YYQAQCMYLLGEYHRAAHTIQHHKLEKNSLPCFNLLLESLYAAKE------FTE 104
            |.|:.|.:.  |:.|:..|.:.||.||||.:::.   ::|:|.| |...|.|.|:|      .|:
  Fly    65 LEGIAPEEYSDYFLAKSYYDVREYDRAAHAVRNC---ESSVPRF-LHFYSSYMAREKRRLDSTTD 125

  Fly   105 AANVIQNVEVEVMTTSLINQPVDASSGCYLESNSVFGGEENHRNELLSSIYLMKGKVYEALDNRG 169
            .||:.:.           ||..|.:                   :||:::.:..||  ..||..|
  Fly   126 QANLHEP-----------NQMRDLA-------------------DLLATLRMEYGK--SRLDGYG 158

  Fly   170 MAMDFYVQALHKSIYCFEALE-ALVQHEML--MAWEEF-ELMHHLPLAQQSSEADAKFILKLYES 230
            :   :....:.|::...:|.| .|||...|  |.|..: ||.   ||..:..        ||...
  Fly   159 I---YLYGVVLKALNLNQAAEQMLVQAIRLVPMLWSAYLELS---PLIMEKK--------KLLSL 209

  Fly   231 RLKKYY--ELISARNAEEMSPIVNPDILQFIKEFTARVQQSGSSDTQMPKVSAVKVPLTPSQFMS 293
            :|..::  ....|....|:  .:|.|.|
  Fly   210 QLGGHWMRHFFMAHTYLEL--YLNDDGL------------------------------------- 235

  Fly   294 PAQKVLEDLKAPTFSLQTSLSKASSLIDASHRSMFDSSSRRRSRDHDTDTLIPIAECLDRVQRST 358
               |:.|||:|..||....|....:|:..:.|
  Fly   236 ---KIYEDLQASGFSKSIYLIAQMALVYHNKR--------------------------------- 264

  Fly   359 DLMAAEAEKCFYDCDYKQCLKILNELLKVDPFHNTALTIQIACLVENGD-FNRLFYV-------- 414
                          |..:.:::...||:.||:.           ::|.| ::.|.:|
  Fly   265 --------------DVDKAIELYQALLESDPYR-----------LDNVDTYSNLLFVKEMKTEMA 304

  Fly   415 --AHKLVDRYPDKAISWYAVGCYYDMIGKSDPARRYLSKATALDRLYGPAWLAYGHSFANENEHE 477
              |||.|.....:..:...:|.||.:......|..|..:|..|:..|..||...||.|.......
  Fly   305 QLAHKAVSINKYRPETCCVIGNYYSIRCDHQVAISYFQRALKLNPKYLAAWTLMGHEFMELKNTN 369

  Fly   478 QAMAAYFKATQLMRGCHLPLLYIGVECGLTKNLELAEKFFLQAMNIAPLDVYVLHELGVIKYEYE 542
            .|:.:|.||.::.:..:.....:|....:.|....:..:|..|..:.|.|..:|..||   ..||
  Fly   370 AAIQSYRKAVEVNKRDYRAWYGLGQAYEIIKMHYYSLYYFKIAHQLRPYDSRMLVALG---ETYE 431

  Fly   543 FFDGAATIFQC---TVDI--------------------------------VKQRAKSNNEEISSR 572
            ..|......:|   .:|:                                ..:||.::.:.:...
  Fly   432 KLDKCENAVKCYWKAIDVGDIEGIAMYKLANLHEKLGDHETAVHCYIMYCEDERAATDKQSLYQG 496

  Fly   573 WEPLFINLGHSLRKVHKYEEALYNFQYALLLKPQSPTTYTSIGFIHALLGNLDPAIE--AFHKSL 635
                ||.|.:...|..:||.|.|                    :.:..|.:.|..:|  |..|::
  Fly   497 ----FITLANYYEKKGEYERAAY--------------------YAYKCLDSEDRKMEAKALLKTI 537

  Fly   636 ALNRDC-----IVTSTILKSCIEDLMDDSATIDEICSAALRDVAKNITANS 681
            ...|:.     :.|||.:.:.      |:::.||: ...|:||...:...|
  Fly   538 DWKRNAEGQKKVKTSTAVANA------DTSSEDEM-EWELQDVRVRVPITS 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdc16	NP_477397.1	ANAPC3	31..112	CDD:463743	23/71 (32%)
		BepA	<373..456	CDD:443813	19/93 (20%)
		TPR	423..>640	CDD:440225	46/253 (18%)
		TPR repeat	426..454	CDD:276809	6/27 (22%)
		TPR repeat	462..488	CDD:276809	9/25 (36%)
		TPR repeat	493..523	CDD:276809	4/29 (14%)
		TPR repeat	528..552	CDD:276809	6/23 (26%)
		TPR repeat	576..602	CDD:276809	8/25 (32%)
		TPR repeat	607..637	CDD:276809	5/31 (16%)
Cdc23	NP_610036.2	ANAPC8	13..119	CDD:427675	20/57 (35%)
		LapB	255..521	CDD:442196	56/350 (16%)
		TPR repeat	255..278	CDD:276809	4/69 (6%)
		TPR repeat	318..346	CDD:276809	6/27 (22%)
		TPR repeat	351..381	CDD:276809	10/29 (34%)
		TPR repeat	386..414	CDD:276809	4/27 (15%)
		TPR repeat	420..448	CDD:276809	7/30 (23%)
		TPR repeat	454..477	CDD:276809	0/22 (0%)
		TPR repeat	494..522	CDD:276809	8/51 (16%)