DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc16 and Cdc16

DIOPT Version :9

Sequence 1:	NP_477397.1	Gene:	Cdc16 / 42753	FlyBaseID:	FBgn0025781	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_001019915.1	Gene:	Cdc16 / 290875	RGDID:	1305076	Length:	620	Species:	Rattus norvegicus

Alignment Length:	728	Identity:	265/728 - (36%)
Similarity:	393/728 - (53%)	Gaps:	143/728 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 IDLALYRQLVKQFIDMRRYSTALFWAEKVAVLGGLEPRDIYYQAQCMYLLGEYHRAAHTIQHHKL 81
            ::|...|:.|:|::|.::|.:|||||:|||.|...||:|:|:.|||:||..:||||||.::..||
  Rat     1 MNLEPLRKRVRQYLDQQQYQSALFWADKVASLSHEEPQDVYWLAQCLYLTAQYHRAAHALRSRKL 65

  Fly    82 EKNSLPCFNLLLESLYAAKEFTEAANVIQNVEVEVMTTSLINQPVDASSGCYLESNSVFGGEENH 146
            :|....|..|.....|||||:.:|.::: ::| |.:...|..:.:...||    |.......|..
  Rat    66 DKLYEACRYLAARCHYAAKEYQQALDIL-DME-EPINRRLFEKYLKDDSG----SKDPSSDWEMS 124

  Fly   147 RNELLSSIYLMKGKVYEALDNRGMAMDFYVQALHKSIYCFEALEALVQHEMLMAWEEFELMHHLP 211
            ::.:.|||.|::||:|:|||||.:|...|.:||...:|||||.:.|..|.||.|.||.||:..||
  Rat   125 QSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKELLDSLP 189

  Fly   212 LAQQSSEADAKFILKLYESRLKKYYELISARNAEEMSPIVNPDILQFIKEFTARVQQSGSSDTQM 276
            |::..:| :.:.:..::|::||||.:
  Rat   190 LSKLCAE-EQELLRFVFENKLKKYNK--------------------------------------- 214

  Fly   277 PKVSAVKVPLTPSQFMSPAQKVLEDLKAPTFSLQTSLSKASSLIDASHRSMFDSSSRRRSRDHDT 341
                       ||
  Rat   215 -----------PS---------------------------------------------------- 216

  Fly   342 DTLIPIAECLDRVQRSTDLMAAEAEKCFYDCDYKQCLKILNELLKVDPFHNTALTIQIACLVENG 406
            :|:||  :.:|.:|.:.|::.:.||:.:|:||:|.|.|:.:.:::.||||...|.:.|..|||..
  Rat   217 ETVIP--QSVDGLQENLDVVVSLAERHYYNCDFKMCYKLTSAVMEKDPFHANCLPVHIGTLVELN 279

  Fly   407 DFNRLFYVAHKLVDRYPDKAISWYAVGCYYDMIG-KSDPARRYLSKATALDRLYGPAWLAYGHSF 470
            ..|.|||::|||||.||...:||:||||||.|:| |::.|||||||||.|::.|||||:||||||
  Rat   280 KANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSF 344

  Fly   471 ANENEHEQAMAAYFKATQLMRGCHLPLLYIGVECGLTKNLELAEKFFLQAMNIAPLDVYVLHELG 535
            |.|:||:|||||||.|.|||:|||||:||||:|.|||.|.:|||:||.||::|||.|.:|:||:|
  Rat   345 AVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFGQALSIAPEDPFVIHEVG 409

  Fly   536 VIKYEYEFFDGAATIFQCTVDIVKQRAKSNNEEISSRWEPLFINLGHSLRKVHKYEEALYNFQYA 600
            |:.::...:..|...|   :|.:::.....||....:||||..||||..||:.||.|||...:.|
  Rat   410 VVAFQNGEWKTAEKWF---LDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQA 471

  Fly   601 LLLKPQSPTTYTSIGFIHALLGNLDPAIEAFHKSLALNRDCIVTSTILKSCIEDLMDDS------ 659
            |:|.||:.:||::||:||:|:||.:.|::.||.:|.|.||...:.|:|..|||..:.||
  Rat   472 LVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGA 536

  Fly   660 ----------------ATIDEICSAA--LRD--VAKNIT--ANSRRVLNSDKFNGMKLKFDEEEE 702
                            .|:..|.|..  .||  |.|..|  |....:.|:.|....:...:|..|
  Rat   537 DIKDKLKCYDFDVHTMKTLKNIISPPWDFRDFEVEKQNTEEAGLAPLENATKTPESRPSLEETFE 601

  Fly   703 FANSDSNMVVEMS 715
            ...::|:|::|.|
  Rat   602 IEMNESDMMLETS 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc16	NP_477397.1	ANAPC3	31..112	CDD:289650	37/80 (46%)
		TPR_11	425..489	CDD:290150	44/64 (69%)
		TPR repeat	426..454	CDD:276809	19/28 (68%)
		TPR repeat	462..488	CDD:276809	20/25 (80%)
		TPR repeat	493..523	CDD:276809	20/29 (69%)
		TPR repeat	528..552	CDD:276809	6/23 (26%)
		TPR_11	576..638	CDD:290150	30/61 (49%)
		TPR repeat	576..602	CDD:276809	13/25 (52%)
		TPR repeat	607..637	CDD:276809	13/29 (45%)
Cdc16	NP_001019915.1	ANAPC3	15..94	CDD:289650	37/78 (47%)
		TPR repeat	36..65	CDD:276809	15/28 (54%)
		TPR repeat	70..94	CDD:276809	8/23 (35%)
		TPR repeat	298..329	CDD:276809	1/30 (3%)
		TPR repeat	336..362	CDD:276809	9/25 (36%)
		TPR repeat	367..397	CDD:276809	11/29 (38%)
		TPR_11	401..476	CDD:290150	53/75 (71%)
		TPR repeat	402..430	CDD:276809	16/28 (57%)
		TPR_11	447..509	CDD:290150	44/61 (72%)
		TPR repeat	447..473	CDD:276809	19/25 (76%)
		TPR	448..478	CDD:197478	22/29 (76%)
		TPR repeat	478..508	CDD:276809	19/29 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340950
Domainoid	1	1.000	250	1.000	Domainoid score	I2047
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2899
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56718
OrthoDB	1	1.010	-	-		D269745at33208
OrthoFinder	1	1.000	-	-		FOG0004793
OrthoInspector	1	1.000	-	-		oto98417
orthoMCL	1	0.900	-	-		OOG6_102501
Panther	1	1.100	-	-	LDO	PTHR12558
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3945
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.860