DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc16 and cut9

DIOPT Version :9

Sequence 1:	NP_477397.1	Gene:	Cdc16 / 42753	FlyBaseID:	FBgn0025781	Length:	718	Species:	Drosophila melanogaster
Sequence 2:	NP_593301.1	Gene:	cut9 / 2541592	PomBaseID:	SPAC6F12.15c	Length:	671	Species:	Schizosaccharomyces pombe

Alignment Length:	721	Identity:	182/721 - (25%)
Similarity:	311/721 - (43%)	Gaps:	172/721 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DTENTSTDTTNEHIDLALYRQLVKQFIDMRRYSTALFWAEKVAVLGGLEPRDIYYQAQCMYLLGE 68
            :.:||.:.:..:::.|..:..|::|     :|..|.|..|||..:.| .|.|.::.||.....|:
pombe    74 NAQNTDSLSREDYLRLWRHDALMQQ-----QYKCAAFVGEKVLDITG-NPNDAFWLAQVYCCTGD 132

  Fly    69 YHRAAHTIQHHKLEKNSLPCFNLLLESLYAAKEFTEAANVIQNVEVEVMTTSLINQPVDASSGCY 133
            |.||...:....|...|..|..|....|....::..|.|::.
pombe   133 YARAKCLLTKEDLYNRSSACRYLAAFCLVKLYDWQGALNLLG----------------------- 174

  Fly   134 LESNSVFGGEENHRNELL---------SSIYLMKGKVYEALDNRGMAMDFYVQALHKSIYCFEAL 189
             |:|. |..:|.:.|:||         :|:..::|:||..|.|...|.:.|.:||.....|:||.
pombe   175 -ETNP-FRKDEKNANKLLMQDGGIKLEASMCYLRGQVYTNLSNFDRAKECYKEALMVDAKCYEAF 237

  Fly   190 EALVQHEMLMAWEEFELMHHLPLAQQSSEADAKFILKLYESRLKKYYELISARNAEEMSPIVNPD 254
            :.||.:.:|.|.||::|:..|..:..|.| ||.|:..||..:|.|
pombe   238 DQLVSNHLLTADEEWDLVLKLNYSTYSKE-DAAFLRSLYMLKLNK-------------------- 281

  Fly   255 ILQFIKEFTARVQQSGSSDTQMPKVSAVKVPLTPSQFMSPAQKVLEDLKAPTFSLQTSLSKASSL 319

pombe   282 ----------------------------------------------------------------- 281

  Fly   320 IDASHRSMFDSSSRRRSRDHDTDTLIPIAECLDRVQRSTDLMAAEAEKCFYDCDYKQCLKILNEL 384
              .||     ....||:.|:        ...::.:::|:||:..:|:..|....:...|.|..::
pombe   282 --TSH-----EDELRRAEDY--------LSSINGLEKSSDLLLCKADTLFVRSRFIDVLAITTKI 331

  Fly   385 LKVDPFHNTALTIQIACLVENGDFNRLFYVAHKLVDRYPDKAISWYAVGCYYDMIGKSDPARRYL 449
            |::||::.....:.:|.|.|:|:.|:|:.:::.||||:|:||::|.|||.||..:.|...||||.
pombe   332 LEIDPYNLDVYPLHLASLHESGEKNKLYLISNDLVDRHPEKAVTWLAVGIYYLCVNKISEARRYF 396

  Fly   450 SKATALDRLYGPAWLAYGHSFANENEHEQAMAAYFKATQLMRGCHLPLLYIGVECGLTKNLELAE 514
            ||::.:|..:||||:.:.||||.|.||:||::||..|.:|.:|.|||.|::|::.....|:.||.
pombe   397 SKSSTMDPQFGPAWIGFAHSFAIEGEHDQAISAYTTAARLFQGTHLPYLFLGMQHMQLGNILLAN 461

  Fly   515 KFFLQAMNIAPLDVYVLHELGVIKYEYEFFDGAATIFQCTVDIVKQRAKSNNEEISSRWEPLFIN 579
            ::...:..:...|..:|:||||:.:.......|...||..:.:|| :.:||.:.    |...:.|
pombe   462 EYLQSSYALFQYDPLLLNELGVVAFNKSDMQTAINHFQNALLLVK-KTQSNEKP----WAATWAN 521

  Fly   580 LGHSLRKVHKYEEALYNFQYALLLKPQSPTTYTSIG--FIHALLGNLDPAIEAFHKSLALNRDCI 642
            |||:.||:..|:.|:......|||.......:|:|.  ::|..:..|  ||...|:|||::.:.|
pombe   522 LGHAYRKLKMYDAAIDALNQGLLLSTNDANVHTAIALVYLHKKIPGL--AITHLHESLAISPNEI 584

  Fly   643 VTSTILKSCIEDLMDDSATIDEICSAALRDVAKNITANSRRVLNSDKFNGMKLKFDEEEEFANSD 707
            :.|.:||..:|:        :.:.|..|         ||:.|     |.....::.::.....||
pombe   585 MASDLLKRALEE--------NSLTSGFL---------NSKYV-----FEDEVSEYMQQSNLNTSD 627

  Fly   708 SNMVVE 713
            .:|.:|
pombe   628 KSMSME 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc16	NP_477397.1	ANAPC3	31..112	CDD:289650	22/80 (28%)
		TPR_11	425..489	CDD:290150	32/63 (51%)
		TPR repeat	426..454	CDD:276809	14/27 (52%)
		TPR repeat	462..488	CDD:276809	14/25 (56%)
		TPR repeat	493..523	CDD:276809	8/29 (28%)
		TPR repeat	528..552	CDD:276809	6/23 (26%)
		TPR_11	576..638	CDD:290150	21/63 (33%)
		TPR repeat	576..602	CDD:276809	8/25 (32%)
		TPR repeat	607..637	CDD:276809	9/31 (29%)
cut9	NP_593301.1	ANAPC3	96..176	CDD:289650	23/109 (21%)
		TPR repeat	149..192	CDD:276809	13/67 (19%)
		TPR_8	200..232	CDD:289924	10/31 (32%)
		TPR repeat	200..227	CDD:276809	8/26 (31%)
		TPR_11	372..436	CDD:290150	32/63 (51%)
		TPR repeat	373..401	CDD:276809	14/27 (52%)
		TPR repeat	406..436	CDD:276809	16/29 (55%)
		TPR repeat	444..469	CDD:276809	5/24 (21%)
		TPR_11	474..546	CDD:290150	24/76 (32%)
		TPR repeat	475..503	CDD:276809	8/27 (30%)
		TPR repeat	508..545	CDD:276809	12/40 (30%)
		TPR_11	516..581	CDD:290150	21/66 (32%)
		TPR_1	516..545	CDD:278916	9/28 (32%)
		TPR repeat	550..578	CDD:276809	8/29 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1173
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2899
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56718
OrthoFinder	1	1.000	-	-		FOG0004793
OrthoInspector	1	1.000	-	-		oto101943
orthoMCL	1	0.900	-	-		OOG6_102501
Panther	1	1.100	-	-	LDO	PTHR12558
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R265
SonicParanoid	1	1.000	-	-		X3945
TreeFam	1	0.960	-	-
	12	11.810