DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment orb and CPEB4

DIOPT Version :9

Sequence 1:	NP_001262870.1	Gene:	orb / 42752	FlyBaseID:	FBgn0004882	Length:	915	Species:	Drosophila melanogaster
Sequence 2:	NP_085130.2	Gene:	CPEB4 / 80315	HGNCID:	21747	Length:	729	Species:	Homo sapiens

Alignment Length:	780	Identity:	206/780 - (26%)
Similarity:	316/780 - (40%)	Gaps:	170/780 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 TPSTSAPILGAGGGGRANGVTAGAATATGVGVGAGGTLPGPGVPSIQGGGGGGVVGQQTNASCNT 169
            |||.:|.|         |..||    |.|...|:....|.|...:||    ..::|.:...|...
Human    38 TPSPAAFI---------NNNTA----ANGSSAGSAWLFPAPATHNIQ----DEILGSEKAKSQQQ 85

  Fly   170 SAANPSASFGGNGSSSDVNNLLLASAAAAAAAAAGDGAQLSANAAAYAPLTPSSTHSSASPGTKS 234
            ...:|......:.|......:|..:..|.:....||.:..:.|......:        .|| ..:
Human    86 EQQDPLEKQQLSPSPGQEAGILPETEKAKSEENQGDNSSENGNGKEKIRI--------ESP-VLT 141

  Fly   235 NFDYFQFENVAQS-NPLKAFQRTNISF-DCSAPLSPSTPTSIYNRS--FHSSPLVSDSSNSSSGI 295
            .|||.:...:..| .||.:...:...| :.||.::||:.|.|...:  ||...:.:.|:|:.:.:
Human   142 GFDYQEATGLGTSTQPLTSSASSLTGFSNWSAAIAPSSSTIINEDASFFHQGGVPAASANNGALL 206

  Fly   296 GLSMDSINMFYNQQQQQQQPEQQGYTSLGNSMGSGLGLSLANASTRSNSPESQNSSNSTTEQNLL 360
                                    :.:..:.:..|.|.|.        ||:
Human   207 ------------------------FQNFPHHVSPGFGGSF--------SPQ-------------- 225

  Fly   361 DMINLLSVNSNKIPHQQQQQQQQQQQQQQQQQQNQQQLQVQQQ--HQLQQQFVNLNR------NY 417
              |..||.:....||.|....|.|||::.....:......:..  :||.....|||:      :|
Human   226 --IGPLSQHHPHHPHFQHHHSQHQQQRRSPASPHPPPFTHRNAAFNQLPHLANNLNKPPSPWSSY 288

  Fly   418 EQQISANLGSQQHGFEHNGVGVGASSSGNE------------NCFSQYNLENITSVDMELAK--- 467
            :........|...|  ..|.|....|.|.:            |..|... :|..|..::|.|
Human   289 QSPSPTPSSSWSPG--GGGYGGWGGSQGRDHRRGLNGGITPLNSISPLK-KNFASNHIQLQKYAR 350

  Fly   468 -----------------LQNL----QRINTLKLLHAQAQQMPLINQLLQSYAGNAIGSVGGSNLG 511
                             ..|:    .|..|..:...::..:.::.....:..|....|..||:..
Human   351 PSSAFAPKSWMEDSLNRADNIFPFPDRPRTFDMHSLESSLIDIMRAENDTIKGRLNYSYPGSDSS 415

  Fly   512 NLMSA-------GGSSLMTEMAGNVGGIITTNDGHLDRVAKFYKSSAALCDATCTWSGHLPPRSH 569
            .|::|       |.|||           ....||.||.........:.|....|.        ||
Human   416 LLINARTYGRRRGQSSL-----------FPMEDGFLDDGRGDQPLHSGLGSPHCF--------SH 461

  Fly   570 ----RMLNYSPKVFLGGIPWDISEQSLIQIFKPFGSIKVEWPGKEQQAA--QPKGYVYIIFESDK 628
                |:..||.|||:||:|.||.|..:...|:.||.:.|:||.|.:..:  .||||.:::|:.:.
Human   462 QNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLIVDWPHKAESKSYFPPKGYAFLLFQDES 526

  Fly   629 QVKALLSACVLQVDDSHCGRNYFFKISSRRIKSKDVEVIPWIIADSNFVRSSSQKLDPTKTVFVG 693
            .|:||:.||:     ...|:.|.. :||..||.|.|::.||.::||:||...||.|||.||:|||
Human   527 SVQALIDACI-----EEDGKLYLC-VSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVG 585

  Fly   694 ALHGKLTAEGLGNIMDDLFDGVLYAGIDTD-KYKYPIGSGRVTFSNFRSYMKAVSAAFIEIRTTK 757
            .:...|.|..|..|||.|:.||.||||||| :.|||.|:|||.|||.:||:.|:||.|::::..:
Human   586 GVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGE 650

  Fly   758 FTKKVQVDPY-LEDALC-----SICGVQHGPYYCRELSCFRYFCRSCWQWQHSCDIVKNHKPLTR 816
            ..|:|:|.|| |:|.||     :.||.:..|::|..::|.:|:|..||...||....:.||||.:
Human   651 IDKRVEVKPYVLDDQLCDECQGARCGGKFAPFFCANVTCLQYYCEYCWAAIHSRAGREFHKPLVK 715

Fly 817 816
Human 716 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
orb	NP_001262870.1	CEBP1_N	<540..570	CDD:292978	6/33 (18%)
		RRM1_CPEB1	574..674	CDD:241167	38/101 (38%)
		RRM2_CPEB1	685..770	CDD:241169	45/86 (52%)
		CEBP_ZZ	762..817	CDD:292976	23/61 (38%)
CPEB4	NP_085130.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..49		6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..133		8/54 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..328		26/135 (19%)
		RRM1_CPEB2_like	472..563	CDD:410123	36/96 (38%)
		RNA-binding. /evidence=ECO:0007744\|PDB:5DIF	541..543		0/1 (0%)
		RRM2_CPEB2_like	580..660	CDD:410125	40/79 (51%)
		CEBP_ZZ	655..716	CDD:406704	23/61 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0129
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810