Protein Alignment orb and Cpeb4

DIOPT Version :10

• Sequence 1: NP_524460.2
• Gene: orb / 42752
• FlyBaseID: FBgn0004882
• Length: 915
• Species: Drosophila melanogaster
• Sequence 2: NP_080528.2
• Gene: Cpeb4 / 67579
• MGIID: 1914829
• Length: 729
• Species: Mus musculus
• Alignment Length: 776
• Identity: 205/776 - (26%)
• Similarity: 316/776 - (40%)
• Gaps: 162/776 - (20%)

  Fly   105 TPSTSAPILGAGGGGRANGVTAGAATATGVGVGAGGTLPGPGVPSIQGGGGGGVVGQQTNASCNT 169
            ||:.:|.|         |..||    |.|...|:....|.|...:||    ..::|.:...|...
Mouse    38 TPNPAAFI---------NNNTA----ANGSSAGSAWLFPAPATHNIQ----DEILGSEKAKSQQQ 85

  Fly   170 SAANPSASFGGNGSSSDVNNLLLASAAAAAAAAAGDGAQLSANAAAYAPLTPSSTHSSASPGTKS 234
            ...:|......:.|......:|..:..|.|....||.:..::|......:        .|| ..:
Mouse    86 EQQDPLEKQQLSPSPGQEAGILPETEKAKAEENPGDSSSENSNGKEKLRI--------ESP-VLT 141

  Fly   235 NFDYFQFENVAQS-NPLKAFQRTNISF-DCSAPLSPSTPTSIYNRS--FHSSPLVSDSSNSSSGI 295
            .|||.:...:..| .||.:...:...| :.||.::||:.|.|...:  ||...:...|:|:.:.:
Mouse   142 GFDYQEATGLGTSTQPLTSSASSLTGFSNWSAAIAPSSSTIINEDASFFHQGGVPGASANNGALL 206

  Fly   296 GLSMDSINMFYNQQQQQQQPEQQGYTSLGNSMGSGLGLSLANASTRSNSPESQNSSNSTTEQNLL 360
                                    :.:..:.:..|.|.|.        ||:
Mouse   207 ------------------------FQNFPHHVSPGFGGSF--------SPQ-------------- 225

  Fly   361 DMINLLSVNSNKIPHQQQQQQQQQQQQQQQQQQNQQQLQVQQQ--HQLQQQFVNLNR------NY 417
              |..||.:....||.|....|.|||::.....:......:..  :||.....|||:      :|
Mouse   226 --IGPLSQHHPHHPHFQHHHSQHQQQRRSPASPHPPPFTHRSAAFNQLPHLANNLNKPPSPWSSY 288

  Fly   418 EQQISANLGSQQHGFEHNGVGVGASSSGNE------------NCFSQYNLENITSVDMELAK--- 467
            :........|...|  ..|.|...:|.|.:            |..|... :|..|..::|.|
Mouse   289 QSPSPTPSSSWSPG--GGGYGGWGASQGRDHRRGLNGGITPLNSISPLK-KNFASNHIQLQKYAR 350

  Fly   468 -----------------LQNL----QRINTLKLLHAQAQQMPLINQLLQSYAGNAIGSVGGSNLG 511
                             ..|:    :|..|..:...::..:.::.....|..|....|..||:..
Mouse   351 PSSAFAPKSWMEDSLNRADNIFPFPERPRTFDMHSLESSLIDIMRAENDSIKGRLNYSYPGSDSS 415

  Fly   512 NLMSA-------GGSSLMTEMAGNVGGIITTNDGHLDRVAKFYKSSAALCDATCTWSGHLPPRSH 569
            .|::|       |.|||           ....||.||.........:.|....|    .......
Mouse   416 LLINARTYGRRRGQSSL-----------FPMEDGFLDDGRGDQPLHSGLGSPHC----FTHQNGE 465

  Fly   570 RMLNYSPKVFLGGIPWDISEQSLIQIFKPFGSIKVEWPGKEQQAA--QPKGYVYIIFESDKQVKA 632
            |:..||.|||:||:|.||.|..:...|:.||.:.|:||.|.:..:  .||||.:::|:.:..|:|
Mouse   466 RVERYSRKVFVGGLPPDIDEDEITASFRRFGPLIVDWPHKAESKSYFPPKGYAFLLFQDESSVQA 530

  Fly   633 LLSACVLQVDDSHCGRNYFFKISSRRIKSKDVEVIPWIIADSNFVRSSSQKLDPTKTVFVGALHG 697
            |:.||:     ...|:.|.. :||..||.|.|::.||.::||:||...||.|||.||:|||.:..
Mouse   531 LIDACI-----EEDGKLYLC-VSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPR 589

  Fly   698 KLTAEGLGNIMDDLFDGVLYAGIDTD-KYKYPIGSGRVTFSNFRSYMKAVSAAFIEIRTTKFTKK 761
            .|.|..|..|||.|:.||.||||||| :.|||.|:|||.|||.:||:.|:||.|::::..:..|:
Mouse   590 PLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGEIDKR 654

  Fly   762 VQVDPY-LEDALC-----SICGVQHGPYYCRELSCFRYFCRSCWQWQHSCDIVKNHKPLTR 816
            |:|.|| |:|.||     :.||.:..|::|..::|.:|:|..||...||....:.||||.:
Mouse   655 VEVKPYVLDDQLCDECQGARCGGKFAPFFCANVTCLQYYCEYCWAAIHSRAGREFHKPLVK 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
orb	NP_524460.2	RRM1_CPEB1	574..674	CDD:410122	38/101 (38%)
		RRM2_CPEB1	685..768	CDD:410124	44/84 (52%)
		CEBP_ZZ	762..817	CDD:465105	23/61 (38%)
Cpeb4	NP_080528.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..50		5/20 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..133		9/54 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	218..324		26/131 (20%)
		RRM1_CPEB2_like	472..563	CDD:410123	36/96 (38%)
		RNA-binding. /evidence=ECO:0000250|UniProtKB:Q17RY0	541..543		0/1 (0%)
		RRM2_CPEB2_like	580..660	CDD:410125	40/79 (51%)
		CEBP_ZZ	655..716	CDD:465105	23/61 (38%)