DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment orb and CPEB1

DIOPT Version :9

Sequence 1:	NP_001262870.1	Gene:	orb / 42752	FlyBaseID:	FBgn0004882	Length:	915	Species:	Drosophila melanogaster
Sequence 2:	NP_001373990.1	Gene:	CPEB1 / 64506	HGNCID:	21744	Length:	593	Species:	Homo sapiens

Alignment Length:	728	Identity:	248/728 - (34%)
Similarity:	346/728 - (47%)	Gaps:	220/728 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 AANPSASFGGNG----SSSDVNNLLLASAAAAAAAAAGDGAQLSANAAAYAPLTPSSTHSSASPG 231
            |.:.|:|..|.|    |.||...|:.....|.......|..:..|.:
Human     6 ATSTSSSMSGTGLEHSSLSDCLLLIPLEEEAGRIKDCWDNQEAPALS------------------ 52

  Fly   232 TKSNFDYFQFENVAQSNPLKAFQRTNISFDCSAPLSPSTPTSIYNRSFHSS-PLVSDS------- 288
            |.||.:.|:..|....|.|. |.|.     |:.|:         ||..|.. |...||
Human    53 TCSNANIFRRINAILDNSLD-FSRV-----CTTPI---------NRGIHDHLPDFQDSEETVTSR 102

  Fly   289 -------SNSSSGIG------LSMDSINMF-YNQQQQQQQPEQQGYTS-----------LGNSMG 328
                   ..||.|:.      |.:.|:::. :::....|..:....:|           |||.:|
Human   103 MLFPTSAQESSRGLPDANDLCLGLQSLSLTGWDRPWSTQDSDSSAQSSTHSVLSMLHNPLGNVLG 167

  Fly   329 ---------SGLGLSLAN-----------------ASTRSNSP-ESQNSSNSTTEQNLLDMINLL 366
                     ..||..|.:                 ..:||:|| :|..|..|:...:|.|:|:.|
Human   168 KPPLSFLPLDPLGSDLVDKFPAPSVRGSRLDTRPILDSRSSSPSDSDTSGFSSGSDHLSDLISSL 232

  Fly   367 SVNSNKIPHQQQQQQQQQQQQQQQQQQNQQQLQVQQQHQLQQQFVNLNRNYEQQISANLGSQQHG 431
            .: |..:|                                   |::|:.          |..:..
Human   233 RI-SPPLP-----------------------------------FLSLSG----------GGPRDP 251

  Fly   432 FEHNGVGVGASSSGNENCFSQYNLENITSVDMELAKLQNLQRINTLKLLHAQAQQMPLINQLLQS 496
            .:   :|||                  :.:|.|.|.|               |...|......:.
Human   252 LK---MGVG------------------SRMDQEQAAL---------------AAVTPSPTSASKR 280

  Fly   497 YAGNAIGSVGGSNLGNLMSAGGSSLMTEMAGNVGGIITTNDGHLDRVAKFYKSSAALCDATCTWS 561
            :.|   .||..|  .:|:.|                 ..:...::|.|:.::.:||:.:||||||
Human   281 WPG---ASVWPS--WDLLEA-----------------PKDPFSIEREARLHRQAAAVNEATCTWS 323

  Fly   562 GHLPPRSHRMLNYSPKVFLGGIPWDISEQSLIQIFKPFGSIKVEWPGKE-------QQAAQPKGY 619
            |.||||:::...||.||||||:||||:|..|:..|:.|||:.||||||:       .:...||||
Human   324 GQLPPRNYKNPIYSCKVFLGGVPWDITEAGLVNTFRVFGSLSVEWPGKDGKHPRCPPKGNMPKGY 388

  Fly   620 VYIIFESDKQVKALLSACVLQVDDSHCG------RNYFFKISSRRIKSKDVEVIPWIIADSNFVR 678
            ||::||.:|.|::||.||      ||..      ..|:||:||||::.|:|:||||::|||||||
Human   389 VYLVFELEKSVRSLLQAC------SHDPLSPDGLSEYYFKMSSRRMRCKEVQVIPWVLADSNFVR 447

  Fly   679 SSSQKLDPTKTVFVGALHGKLTAEGLGNIMDDLFDGVLYAGIDTDKYKYPIGSGRVTFSNFRSYM 743
            |.||:|||::|||||||||.|.||.|..|::|||.||:||||||||:|||||||||||:|.|||:
Human   448 SPSQRLDPSRTVFVGALHGMLNAEALAAILNDLFGGVVYAGIDTDKHKYPIGSGRVTFNNQRSYL 512

  Fly   744 KAVSAAFIEIRTTKFTKKVQVDPYLEDALCSICGVQHGPYYCRELSCFRYFCRSCWQWQHSCDIV 808
            |||||||:||:|||||||||:||||||:||.||..|.||::||:..||:|||||||.|:||.:.:
Human   513 KAVSAAFVEIKTTKFTKKVQIDPYLEDSLCHICSSQPGPFFCRDQVCFKYFCRSCWHWRHSMEGL 577

  Fly   809 KNHKPLTRNSKSQ 821
            ::|.||.||.|::
Human   578 RHHSPLMRNQKNR 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
orb	NP_001262870.1	CEBP1_N	<540..570	CDD:292978	15/29 (52%)
		RRM1_CPEB1	574..674	CDD:241167	54/112 (48%)
		RRM2_CPEB1	685..770	CDD:241169	66/84 (79%)
		CEBP_ZZ	762..817	CDD:292976	32/54 (59%)
CPEB1	NP_001373990.1	CEBP1_N	31..334	CDD:406706	80/439 (18%)
		RRM1_CPEB1	336..443	CDD:410122	54/112 (48%)
		RRM2_CPEB1	454..537	CDD:410124	64/82 (78%)
		CEBP_ZZ	531..586	CDD:406704	32/54 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158366
Domainoid	1	1.000	149	1.000	Domainoid score	I4436
eggNOG	1	0.900	-	-		E1_KOG0129
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005701
OrthoInspector	1	1.000	-	-		oto91491
orthoMCL	1	0.900	-	-		OOG6_107196
Panther	1	1.100	-	-	LDO	PTHR12566
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5171
SonicParanoid	1	1.000	-	-		X4096
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.770