DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment orb and Cpeb3

DIOPT Version :9

Sequence 1:	NP_001262870.1	Gene:	orb / 42752	FlyBaseID:	FBgn0004882	Length:	915	Species:	Drosophila melanogaster
Sequence 2:	NP_001277755.1	Gene:	Cpeb3 / 208922	MGIID:	2443075	Length:	716	Species:	Mus musculus

Alignment Length:	747	Identity:	204/747 - (27%)
Similarity:	288/747 - (38%)	Gaps:	224/747 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   214 AAYAPLTPSSTH------SSASPGTKSNFDYFQFENVAQSNPLKAFQRTNISFDCSAPLSPSTPT 272
            ||.||.||.|:.      |||.|...                           ..|||.:|:.|
Mouse    36 AAEAPSTPLSSEIPKPEDSSAVPALS---------------------------PASAPPAPNGP- 72

  Fly   273 SIYNRSFHSSPLVSDSSNSSSGIGLSMDSINMFYNQQQQQQQPEQQGYTSLGNSMGSGLGLSLAN 337
               ::....|||:.         |||.        .|..||.|..|..|:.|.|:....|.:.:.
Mouse    73 ---DKMQMESPLLP---------GLSF--------HQPPQQPPPPQEPTAPGASLSPSFGSTWST 117

  Fly   338 ASTRSNSPESQNSSNSTTE------QNLLDMINLL--SVNSNKIPHQQQQQQQQQQQQQQQQQQN 394
            .:|  |:.|.......|..      ||....:|.:  ...|.:|...|.|..||......|..|.
Mouse   118 GTT--NAVEDSFFQGITPVNGTMLFQNFPHHVNPVFGGTFSPQIGLAQTQHHQQPPPPAPQPPQP 180

  Fly   395 QQQLQVQQQHQLQQQFVNLNRNYEQQISANLGSQ------------------------------- 428
            .|..|.|...|.:.........|.|:.:|..|.|
Mouse   181 AQPPQAQPSQQRRSPASPSQAPYAQRSAAAYGHQPIMTSKPSSSSAVAAAAAAAAASSASSSWNT 245

  Fly   429 ------------------QHGFEHN-------GVGVGASSSGN---------------------- 446
                              |.|.:..       |||||..|..|
Mouse   246 HQSVNAAWSAPSNPWGGLQAGRDPRRAVGVGVGVGVGVPSPLNPISPLKKPFSSNVIAPPKFPRA 310

  Fly   447 ----------ENCFSQYNLENITSVD--------MELAKLQN--LQRINT----LKLLHAQAQQM 487
                      :|.|...|..|:....        ..|..|:|  :..|.|    ||..|......
Mouse   311 APLTSKSWMEDNAFRTDNGNNLLPFQDRSRPYDTFNLHSLENSLMDMIRTDHEPLKGKHYPPSGP 375

  Fly   488 PLINQLLQSYA-----GNAIGSVG------GSNLGNLMSAGGSSLMTEMAGNVGGIIT------- 534
            |:      |:|     .:..|.:|      |::  |:|     :|.|...|...|..:
Mouse   376 PM------SFADIMWRNHFAGRMGINFHHPGTD--NIM-----ALNTRSYGRRRGRSSLFPFEDA 427

  Fly   535 -TNDGHLDRVAKFYKSSAALCDATCTWSGHLPPRSHRMLNYSPKVFLGGIPWDISEQSLIQIFKP 598
             .:|.|.|:......||...|.           ...|:..||.|||:||:|.||.|..:...|:.
Mouse   428 FLDDSHGDQALSSGLSSPTRCQ-----------NGERVERYSRKVFVGGLPPDIDEDEITASFRR 481

  Fly   599 FGSIKVEWPGKEQQAA--QPKGYVYIIFESDKQVKALLSACVLQVDDSHCGRNYFFKISSRRIKS 661
            ||.:.|:||.|.:..:  .||||.:::|:.:..|:||:.|| |:.|    |:.|.. :||..||.
Mouse   482 FGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDAC-LEED----GKLYLC-VSSPTIKD 540

  Fly   662 KDVEVIPWIIADSNFVRSSSQKLDPTKTVFVGALHGKLTAEGLGNIMDDLFDGVLYAGIDTD-KY 725
            |.|::.||.::||:||...||.|||.||:|||.:...|.|..|..|||.|:.||.||||||| :.
Mouse   541 KPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPEL 605

  Fly   726 KYPIGSGRVTFSNFRSYMKAVSAAFIEIRTTKFTKKVQVDPY-LEDALC-----SICGVQHGPYY 784
            |||.|:|||.|||.:||:.|:||.|::::.....|:|:|.|| |:|.:|     :.||.:..|::
Mouse   606 KYPKGAGRVAFSNQQSYIAAISARFVQLQHNDIDKRVEVKPYVLDDQMCDECQGTRCGGKFAPFF 670

  Fly   785 CRELSCFRYFCRSCWQWQHSCDIVKNHKPLTR 816
            |..::|.:|:|..||...||....:.||||.:
Mouse   671 CANVTCLQYYCEYCWASIHSRAGREFHKPLVK 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
orb	NP_001262870.1	CEBP1_N	<540..570	CDD:292978	4/29 (14%)
		RRM1_CPEB1	574..674	CDD:241167	40/101 (40%)
		RRM2_CPEB1	685..770	CDD:241169	45/86 (52%)
		CEBP_ZZ	762..817	CDD:292976	22/61 (36%)
Cpeb3	NP_001277755.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..118		31/129 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..209		12/46 (26%)
		RRM1_CPEB2_like	459..550	CDD:241168	38/96 (40%)
		RRM2_CPEB2_like	567..647	CDD:241170	40/79 (51%)
		CEBP_ZZ	642..703	CDD:374504	22/61 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0129
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810