Protein Alignment orb and CPEB2

DIOPT Version :9

• Sequence 1: NP_001262870.1
• Gene: orb / 42752
• FlyBaseID: FBgn0004882
• Length: 915
• Species: Drosophila melanogaster
• Sequence 2: XP_005248192.2
• Gene: CPEB2 / 132864
• HGNCID: 21745
• Length: 1037
• Species: Homo sapiens
• Alignment Length: 952
• Identity: 246/952 - (25%)
• Similarity: 348/952 - (36%)
• Gaps: 311/952 - (32%)

  Fly    30 LLQKHSISSYLDHHHQQQQQQQHHLQLQQHQQQHSLLERCNDDGLISFINDPITLNDLLGL---C 91
            |||    .:.|....|||..||..|..|||........|          ..|..|..|..|   .
Human   218 LLQ----PAQLAQRQQQQPPQQFSLLHQQHLSPQDFAPR----------QRPADLPPLPQLPPSP 268

  Fly    92 GASTANEVVGTGQTPSTSAPILGAGGGGRANGVTAGAATATGV---------------------- 134
            .|:......|.|....|.|    ||.|..|....||.|::|.|
Human   269 PAAPRRRHGGAGSPRKTPA----AGEGSAAESPNAGLASSTPVNPAPGSMESPNHPLLNSPSNLL 329

  Fly   135 -----GVGAGGTLPGPGVPSIQGGGGGGVVGQQTNASCNTSAANPSASFGGNGSSSDVNNLLLAS 194
                 |.||..:|..|.:|...||||||             ...|....||.||:|.
Human   330 PGGALGAGAFSSLQSPDLPHPGGGGGGG-------------GGGPPGGGGGGGSASP-------- 373

  Fly   195 AAAAAAAAAGDGAQLSANAAAYAPL----TPSSTHSSASPGTKSNFDYFQFENVAQSNPLKAFQR 255
                                  .||    ||.|..:::.|           ....|..|.:..|:
Human   374 ----------------------PPLPGFGTPWSVQTASPP-----------PQPQQPPPTQPQQQ 405

  Fly   256 TNISFDCSAPLSPSTPTSIYNRSFHSSPLVSDSSNSSSGIGLSM--------DSINMFYNQQQQQ 312
            .      ..|..|..|        ...|..|.::....|.|.|:        ||.|.||......
Human   406 P------PPPQQPPQP--------QPQPPGSSATTPGGGSGGSLSAMPPPSPDSENGFYPGLPSS 456

  Fly   313 QQP---------EQQGYTSL----GNSMGSGLGLSLANASTRSNSPESQNSSNSTTEQNLLDMIN 364
            ..|         ...|.|.|    ....|.|.|...:..:.....|.:.|
Human   457 MNPAFFPSFSPVSPHGCTGLSVPTSGGGGGGFGGPFSATAVPPPPPPAMN--------------- 506

  Fly   365 LLSVNSNKIPHQQQQQQQQQQQQQQQQQQNQQQLQVQQQHQ------LQQQFVNLNRNYEQQI-- 421
                    ||  |||.......||.|.:::....|:|||||      |||:   .:.|:.|.:
Human   507 --------IP--QQQPPPPAAPQQPQSRRSPVSPQLQQQHQAAAAAFLQQR---NSYNHHQPLLK 558

  Fly   422 --------SANLGS------QQHGFEHNGVG-VGASS------------SGN------------- 446
                    |:..|:      ..||.:|...| :|...            |||
Human   559 QSPWSNHQSSGWGTGSMSWGAMHGRDHRRTGNMGIPGTMNQISPLKKPFSGNVIAPPKFTRSTPS 623

  Fly   447 --------ENCFSQYNLEN---------------------------------ITSVDMELAKLQN 470
                    :|.|...|..|                                 .:.:|.:.:::.:
Human   624 LTPKSWIEDNVFRTDNNSNTLLPLQVRMVRSSLQLPAWGSDSLQDSWCTAAGTSRIDQDRSRMYD 688

  Fly   471 LQRINTLK--LLH-AQAQQMPLINQLLQSYAGNAIGSVGGSNLGNLM---------SAGGSSLMT 523
            ...:::|:  |:. .:|:..||..:|...:.|.          .||:         ..|.|||..
Human   689 SLNMHSLENSLIDIMRAEHDPLKGRLSYPHPGT----------DNLLMLNARSYGRRRGRSSLFP 743

  Fly   524 EMAGNVGGIITTNDGHLDRVAKFYKSSAALCDATCTWSGHLPPRSHRMLNYSPKVFLGGIPWDIS 588
            ...|      ..:|||.|:|       ..|...|| :|.|  ....|:..:|.|||:||:|.||.
Human   744 IDDG------LLDDGHSDQV-------GVLNSPTC-YSAH--QNGERIERFSRKVFVGGLPPDID 792

  Fly   589 EQSLIQIFKPFGSIKVEWPGKEQQAA--QPKGYVYIIFESDKQVKALLSACVLQVDDSHCGRNYF 651
            |..:...|:.||.:.|:||.|.:..:  .||||.:::|:.:..|:||:.||:     ...|:.|.
Human   793 EDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACI-----EEDGKLYL 852

  Fly   652 FKISSRRIKSKDVEVIPWIIADSNFVRSSSQKLDPTKTVFVGALHGKLTAEGLGNIMDDLFDGVL 716
            . :||..||.|.|::.||.::||:||...||.|||.||:|||.:...|.|..|..|||.|:.||.
Human   853 C-VSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVC 916

  Fly   717 YAGIDTD-KYKYPIGSGRVTFSNFRSYMKAVSAAFIEIRTTKFTKKVQVDPY-LEDALC-----S 774
            ||||||| :.|||.|:|||.|||.:||:.|:||.|::::.....|:|:|.|| |:|.:|     :
Human   917 YAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGDIDKRVEVKPYVLDDQMCDECQGA 981

  Fly   775 ICGVQHGPYYCRELSCFRYFCRSCWQWQHSCDIVKNHKPLTR 816
            .||.:..|::|..::|.:|:|..||...||....:.||||.:
Human   982 RCGGKFAPFFCANVTCLQYYCEFCWANIHSRAGREFHKPLVK 1023

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
orb	NP_001262870.1	CEBP1_N	<540..570	CDD:292978	7/29 (24%)
		RRM1_CPEB1	574..674	CDD:241167	37/101 (37%)
		RRM2_CPEB1	685..770	CDD:241169	45/86 (52%)
		CEBP_ZZ	762..817	CDD:292976	22/61 (36%)
CPEB2	XP_005248192.2	RRM	<767..942	CDD:223796	80/182 (44%)
		RRM1_CPEB2_like	780..871	CDD:241168	36/96 (38%)
		RRM2_CPEB2_like	888..968	CDD:241170	40/79 (51%)
		CEBP_ZZ	963..1024	CDD:292976	22/61 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0129
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810