DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment orb and cpeb4b

DIOPT Version :9

Sequence 1:	NP_001262870.1	Gene:	orb / 42752	FlyBaseID:	FBgn0004882	Length:	915	Species:	Drosophila melanogaster
Sequence 2:	NP_001338642.1	Gene:	cpeb4b / 100333151	ZFINID:	ZDB-GENE-170601-167	Length:	726	Species:	Danio rerio

Alignment Length:	891	Identity:	219/891 - (24%)
Similarity:	325/891 - (36%)	Gaps:	280/891 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PLLQ-QYDTPDCSGSGG---NMRALSGGSTTELLQKHSISSYL-----DHHHQQQQ--------- 48
            |.|| .:..|:.:.|..   |......||:       |.|::|     .|::.|.:
Zfish    26 PHLQPPHHHPNATASPAAFINSTPAGNGSS-------SASTWLFPAAGGHNNMQDEILGSDKPKV 83

  Fly    49 QQQHHLQLQQHQQQHSLLERCNDDGLISFINDPITLNDLLGLCGASTANEVVGTGQTPSTS---- 109
            |||...:.|..|||..|.....:..:||.:..            |......|.:|.:..|:
Zfish    84 QQQELQETQDKQQQQQLSPGHQESTIISELEK------------ARAEEGKVESGSSEGTNGKEK 136

  Fly   110 ----APILGAGGGGRANGVTAGAATATGVGVGAGGTLPGPGVPSIQGGGGGGVVGQQTNASCNTS 170
                :|:|.|.                                ..|...|.|...|.:.:|..||
Zfish   137 LRLESPVLTAF--------------------------------DYQEPSGLGTAAQSSTSSSLTS 169

  Fly   171 AANPSASFGGNGS---SSDVNNLLLASAAAAAAAAAGDGAQLSANAAAYAPLTPSSTHSSASPGT 232
            ..|.||:.....|   :.|::..       ..||:|.:|..|..|.:.:           .|||.
Zfish   170 FNNWSAAIPATPSTIINEDISFF-------NPAASANNGPLLFQNFSHH-----------VSPGF 216

  Fly   233 KSNFDYFQFENVAQSNPLKA-FQRTNISFD--CSAPLSP----------------------STPT 272
            ..||.. |...::|.:|... ||..:....  ..:|.||                      |.|.
Zfish   217 GGNFSP-QIGPISQHHPPHPHFQHPHSQHQQHRRSPASPHPPPFPHRSAPFGQLPHLSNNLSKPP 280

  Fly   273 SIYNRSFHSSPLVSDSSNSSSGIGLSMDSINMFYNQQQQQQQPEQQGYTSLGNSMGSGL--GLSL 335
            |.:..  :.||..|.||.|.|..|                      ||...|.|.|...  ||:.
Zfish   281 SPWGS--YQSPSPSPSSTSWSPGG----------------------GYGGWGGSQGREYRRGLNG 321

  Fly   336 ANASTRSNSPESQNSSNSTTEQNLLDMINLLSVNSNKIPHQQQQQQQ---QQQQQQQQQQQNQQQ 397
            ......|.||..:...|                  |.:|.|:..:..   ..:.....:.:|...
Zfish   322 GMTPLNSISPLKKTFPN------------------NHMPQQKYSRASPGFNPKSWMDDRSENIFP 368

  Fly   398 LQVQ-------QQHQLQQQFVNLNRNYEQQISANLGSQQHGFEHNGVGVGASSSGNENCFSQYNL 455
            .|.:       ..|.|:...:::.|..:..:...|     ||.|.|
Zfish   369 FQDRPRSFDGFNMHSLENSLIDIMRAEQDTLKGRL-----GFTHPG------------------- 409

  Fly   456 ENITSVDMELAKLQNLQRINTLKLLHAQAQQMPLINQLLQSYAGNAIGSVGGSNLGNLMSAGGSS 520
                                                       |::...:...|.|.  ..|.||
Zfish   410 -------------------------------------------GDSPLPINARNYGR--RRGHSS 429

  Fly   521 LMTEMAGNVGGIITTNDGHLDRVAKFYKSSAALCDATCTWSGHLPPRS-HRMLNYSPKVFLGGIP 584
            |           ....||..|. .:..:|...|....|     .|.:: .|:..||.|||:||:|
Zfish   430 L-----------FPMEDGFPDE-ERADQSLPGLSSPHC-----FPHQNGERVERYSRKVFVGGLP 477

  Fly   585 WDISEQSLIQIFKPFGSIKVEWPGKEQQAA--QPKGYVYIIFESDKQVKALLSACVLQVDDSHCG 647
            .||.|..:...|:.||.:.|:||.|.:..:  .||||.:::|:.:..|:||:.||:     ...|
Zfish   478 PDIDEDEITASFRRFGHLFVDWPHKAESKSYFPPKGYAFLLFQDESSVQALIDACI-----EEDG 537

  Fly   648 RNYFFKISSRRIKSKDVEVIPWIIADSNFVRSSSQKLDPTKTVFVGALHGKLTAEGLGNIMDDLF 712
            :.|.. :||..||.|.|::.||.:.||:||...||.|||.||:|||.:...|.|..|..|||.|:
Zfish   538 KLYLC-VSSPTIKDKPVQIRPWNLNDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLY 601

  Fly   713 DGVLYAGIDTD-KYKYPIGSGRVTFSNFRSYMKAVSAAFIEIRTTKFTKKVQVDPY-LEDALC-- 773
            .||.||||||| :.|||.|:|||.|||.:||:.|:||.|::::..:..|:|:|.|| |:|.||
Zfish   602 GGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHGEIDKRVEVKPYVLDDQLCDE 666

  Fly   774 ---SICGVQHGPYYCRELSCFRYFCRSCWQWQHSCDIVKNHKPLTR 816
               :.||.:..|::|..::|.:|:|..||...||....:.||||.:
Zfish   667 CQGTRCGGKFAPFFCANVTCLQYYCEYCWAAIHSRAGREFHKPLVK 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
orb	NP_001262870.1	CEBP1_N	<540..570	CDD:292978	5/30 (17%)
		RRM1_CPEB1	574..674	CDD:241167	38/101 (38%)
		RRM2_CPEB1	685..770	CDD:241169	45/86 (52%)
		CEBP_ZZ	762..817	CDD:292976	23/61 (38%)
cpeb4b	NP_001338642.1	RRM1_CPEB2_like	469..560	CDD:241168	36/96 (38%)
		RRM2_CPEB2_like	577..657	CDD:241170	40/79 (51%)
		CEBP_ZZ	652..713	CDD:318563	23/61 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910