DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wda and CAF4

DIOPT Version :9

Sequence 1:	NP_651136.1	Gene:	wda / 42750	FlyBaseID:	FBgn0039067	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_012962.3	Gene:	CAF4 / 853908	SGDID:	S000001744	Length:	643	Species:	Saccharomyces cerevisiae

Alignment Length:	608	Identity:	121/608 - (19%)
Similarity:	224/608 - (36%)	Gaps:	189/608 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 EAAESDDTVAHFRSSKYELHTTAVVVNRICAYLQRRGHVLIMNLLYTWLHVHIVENEQRAFSEDH 283
            ::|.:...:||....:|.|...|...|....:...:..|.|:              :||.
Yeast    80 DSATTFRILAHLDEQRYPLPNGAAEKNLPSLFEGFKATVSII--------------QQRL----- 125

  Fly   284 LLGLTDDLEGEDGEDDVVSKPAVTLNTRGDIRPSKSLTEKSNRKRPAEEPNIMLETDIKQEVE-- 346
               |.|:::|....|.........:|| |.:..:.|..:.::          :|| |::..||
Yeast   126 ---LLDNVDGATNSDKEKYVQLPDINT-GFVNKTYSRIDLTH----------LLE-DVETNVENL 175

  Fly   347 ----TDESAELSKLQLNIDACLDTLKSATEQILKSQVELPRFLRISERSRGLTSAHLDPSECHML 407
                |.|..||::|    |:.::.|:|             |.|:|.||.:     |:|....::
Yeast   176 SINKTLEMDELTRL----DSMINELES-------------RKLKILERVK-----HIDSKSTNL- 217

  Fly   408 AGFDNSAVQ-------LWQLNQSYCRGKSFYRRYPQKRCPWELNNCANQEEE----TDEDSSDED 461
               :|....       :.:.|....|.:|..::..::|.. |.::....||.    .|.:|.|..
Yeast   218 ---ENDVTLIKDRINFIEEYNLEADREQSLRKQMEEERSS-EASSFTQNEEAISSLCDVESKDTR 278

  Fly   462 VKCSEEERRERNRARHCKYADNSYN-EYGGFQLR----GHTKGVTDVRFSAHYPLMYSVS-KDAT 520
            :|...:...|::..::.:....:|: ....|::.    .|...:|.:.|...:..:.|.| :|..
Yeast   279 LKDFYKMPHEKSHDKNRQIISETYSRNTTAFRMTIPHGEHGNSITALDFDTPWGTLCSSSYQDRI 343

  Fly   521 MRCWRAHN-------------LHCAAIYRSHNYPIWCLDESPVGQYVVTGSKDLSARLWSLEKEH 572
            ::.|..::             ::|..|.:. ||           ..::|||||.:.:||.|....
Yeast   344 VKVWDLNHGIQVGELPGHLATVNCMQIDKK-NY-----------NMLITGSKDATLKLWDLNLSR 396

  Fly   573 ALIIYAGH------TQDV-------------ECVAFHPNGNYIATGSADHSVRLWCATSGKLMRV 618
            .  ||..|      |:::             |..|...:...:.:||.|..:..|..|:||
Yeast   397 E--IYLDHSPLKEKTEEIVTPCIHNFELHKDEITALSFDSEALVSGSRDKKIFHWDLTTGK---- 455

  Fly   619 FADCRQAVTQLAFSP---DGKM----------------------------LAAAGEETKVRIFDL 652
               |.|.: .|.|:|   |.||                            ||...::..||::||
Yeast   456 ---CIQQL-DLIFTPTHSDIKMPARSLNNGACLLGTEAPMIGALQCYNSALATGTKDGIVRLWDL 516

  Fly   653 AAGAQLAELKDHSASISSLSWSTHNRHLATACSDGTLRLWDIKKLS---------PMSDNSSAGS 708
            ..|..:..|:.|:..|:||.:.:..  |.|...|.::|:||::..|         |:|.....|
Yeast   517 RVGKPVRLLEGHTDGITSLKFDSEK--LVTGSMDNSVRIWDLRTSSILDVIAYDLPVSSLDFDG- 578

  Fly   709 SSSATTNRVLTVNSSCQRLVDVF 731
                   :::||.:: :..|:||
Yeast   579 -------KLITVGAN-EGGVNVF 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wda	NP_651136.1	TAF5_NTD2	104..273	CDD:298747	9/53 (17%)
		WD40	324..>700	CDD:225201	94/470 (20%)
		WD40	491..700	CDD:238121	60/285 (21%)
		WD40 repeat	501..537	CDD:293791	8/49 (16%)
		WD40 repeat	542..578	CDD:293791	9/35 (26%)
		WD40 repeat	585..619	CDD:293791	9/33 (27%)
		WD40 repeat	626..662	CDD:293791	13/66 (20%)
CAF4	NP_012962.3	Caf4	65..124	CDD:402971	9/57 (16%)
		WD40	318..641	CDD:238121	67/309 (22%)
		WD40 repeat	322..360	CDD:293791	6/37 (16%)
		WD40 repeat	366..422	CDD:293791	16/69 (23%)
		WD40 repeat	427..461	CDD:293791	10/41 (24%)
		WD40 repeat	472..526	CDD:293791	9/53 (17%)
		WD40 repeat	532..563	CDD:293791	10/32 (31%)
		WD40 repeat	571..611	CDD:293791	7/32 (22%)
		WD40 repeat	617..641	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900