DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wda and TAF5

DIOPT Version :9

Sequence 1:	NP_651136.1	Gene:	wda / 42750	FlyBaseID:	FBgn0039067	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_009757.1	Gene:	TAF5 / 852497	SGDID:	S000000402	Length:	798	Species:	Saccharomyces cerevisiae

Alignment Length:	863	Identity:	194/863 - (22%)
Similarity:	326/863 - (37%)	Gaps:	244/863 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NHAHAASPVYSNSNNNKSSASSKKTS------------------SKNDLLRCAVGLLLKQKNYVS 54
            |..|...||.:...||.:.|:|.:..                  |.:||.|..:..|.| |.|..
Yeast    12 NGTHQPQPVKNQRTNNAAGANSGQQPQQQSQGQSQQQGRSNGPFSASDLNRIVLEYLNK-KGYHR 75

  Fly    55 NERFRRSD---FLLLQNKQQFA---------------------------VNKMLDTDLHGG--NS 87
            .|...|::   .|..||||..|                           .|.....|..||  :|
Yeast    76 TEAMLRAESGRTLTPQNKQSPANTKTGKFPEQSSIPPNPGKTAKPISNPTNLSSKRDAEGGIVSS 140

  Fly    88 FTFSNVQVITNNQHTVDQQFGRFSQFVEAQAEPLRLEMKRFYGPMLCHFYLDLLKAREPRGAVEL 152
            .....:    |......:.:.....:|::..|..:.|:.....|:..:.:|:|: |:.|
Yeast   141 GRLEGL----NAPENYIRAYSMLKNWVDSSLEIYKPELSYIMYPIFIYLFLNLV-AKNP------ 194

  Fly   153 LRKYAHLVAPVDMYDAPPPTKINGCSTTANESTFNIRFAKEAQDTGDTELDYFMRLVQTLSGYTR 217
              .||.                          .|..||:.:.:|...:|::   ||....|
Yeast   195 --VYAR--------------------------RFFDRFSPDFKDFHGSEIN---RLFSVNS---- 224

  Fly   218 LEAAESDDTVAHFRSSKYELHTTAVVVNRICAYLQRR---GHVLIMNLLYTWLHVHIVEN-EQRA 278
            ::..:.::..:.|:|.||.:..:...:|.:..:|...   |..||::::...|..:|||: ..|.
Yeast   225 IDHIKENEVASAFQSHKYRITMSKTTLNLLLYFLNENESIGGSLIISVINQHLDPNIVESVTARE 289

  Fly   279 FSEDHLLGLTDDLEGEDGEDDVVSKPAVTL-----------------------------NTRGD- 313
            ...|.:..|:|...|...::..::...|.|                             .|.||
Yeast   290 KLADGIKVLSDSENGNGKQNLEMNSVPVKLGPFPKDEEFVKEIETELKIKDDQEKQLNQQTAGDN 354

  Fly   314 ---------IRPSKSLTEKSNRKRPAEEPNIMLETDIKQEVETDESAELSKLQLNIDACLDTLKS 369
                     ::..|::..:..:....::.    :..||.::..||..:.|:|:::.:.....|.|
Yeast   355 YSGANNRTLLQEYKAMNNEKFKDNTGDDD----KDKIKDKIAKDEEKKESELKVDGEKKDSNLSS 415

  Fly   370 ATEQIL----KSQVELPRFLRISERSRGLTSAHLD------PSECH------------------- 405
            ....||    |:.::|.  |.|.:......:..||      ||.|.
Yeast   416 PARDILPLPPKTALDLK--LEIQKVKESRDAIKLDNLQLALPSVCMYTFQNTNKDMSCLDFSDDC 478

  Fly   406 --MLAGFDNSAVQLWQLNQSYCRGKSFYRRYPQKRCPWELN--NCANQEEETDEDSSDEDVKCSE 466
              ..|||.:|.:::|.|:.|                  .||  |.|....:.|||.:
Yeast   479 RIAAAGFQDSYIKIWSLDGS------------------SLNNPNIALNNNDKDEDPT-------- 517

  Fly   467 EERRERNRARHCKYADNSYNEYGGFQLRGHTKGVTDVRFSAHYPLMYSVSKDATMRCWRAHNLHC 531
                       ||            .|.||:..|....||.....:.|.|:|.|:|.| :.:.|.
Yeast   518 -----------CK------------TLVGHSGTVYSTSFSPDNKYLLSGSEDKTVRLW-SMDTHT 558

  Fly   532 AAI-YRSHNYPIWCLDESPVGQYVVTGSKDLSARLWSLEKEHALIIYAGHTQDVECVAFHPNGNY 595
            |.: |:.||:|:|.:..||:|.|..|.|.|.:|||||.:..:.|.|:|||..||:||:|||||.|
Yeast   559 ALVSYKGHNHPVWDVSFSPLGHYFATASHDQTARLWSCDHIYPLRIFAGHLNDVDCVSFHPNGCY 623

  Fly   596 IATGSADHSVRLWCATSGKLMRVFADCRQAVTQLAFSPDGKMLAAAGEETKVRIFDLAAGAQLAE 660
            :.|||:|.:.|:|..::|..:|:|......|..:|..|||:.|:...|:..:.::|:..|.:|.:
Yeast   624 VFTGSSDKTCRMWDVSTGDSVRLFLGHTAPVISIAVCPDGRWLSTGSEDGIINVWDIGTGKRLKQ 688

  Fly   661 LKDHSA-SISSLSWSTHNRHLATACSDGTLRLWDIKKL----SPMSDNSSAGSSSSATTNRVLTV 720
            ::.|.. :|.|||:|.....|.:..:|.|:|:||:||.    |...|....|.....|.    ::
Yeast   689 MRGHGKNAIYSLSYSKEGNVLISGGADHTVRVWDLKKATTEPSAEPDEPFIGYLGDVTA----SI 749

  Fly   721 NSSCQRLVDVFYGTSKTL 738
            |...:.     ||..:|:
Yeast   750 NQDIKE-----YGRRRTV 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wda	NP_651136.1	TAF5_NTD2	104..273	CDD:298747	29/171 (17%)
		WD40	324..>700	CDD:225201	115/414 (28%)
		WD40	491..700	CDD:238121	80/214 (37%)
		WD40 repeat	501..537	CDD:293791	11/36 (31%)
		WD40 repeat	542..578	CDD:293791	15/35 (43%)
		WD40 repeat	585..619	CDD:293791	16/33 (48%)
		WD40 repeat	626..662	CDD:293791	10/35 (29%)
TAF5	NP_009757.1	LisH	55..88	CDD:128913	10/33 (30%)
		TFIID_NTD2	149..275	CDD:398277	27/167 (16%)
		WD40	458..722	CDD:238121	92/313 (29%)
		WD40 repeat	470..523	CDD:293791	17/101 (17%)
		WD40 repeat	529..565	CDD:293791	11/36 (31%)
		WD40 repeat	570..606	CDD:293791	15/35 (43%)
		WD40 repeat	613..648	CDD:293791	16/34 (47%)
		WD40 repeat	654..690	CDD:293791	10/35 (29%)
		WD40 repeat	697..732	CDD:293791	13/34 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346819
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19879
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.900