DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wda and RAD28

DIOPT Version :9

Sequence 1:	NP_651136.1	Gene:	wda / 42750	FlyBaseID:	FBgn0039067	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_010313.3	Gene:	RAD28 / 851594	SGDID:	S000002437	Length:	506	Species:	Saccharomyces cerevisiae

Alignment Length:	449	Identity:	80/449 - (17%)
Similarity:	157/449 - (34%)	Gaps:	110/449 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   366 TLKSATEQILKSQVELPRFLRISERSR-----------GLTSAHLDPSECHMLAGFDNSAVQLWQ 419
            |::|..|:||:..:...:..|.|::|.           |:....:|.:...:|.|.|:.::.:|.
Yeast    21 TIQSEFERILEDPLSNMKNYRFSKQSNYSTKEKTPLSIGVNCLDIDDTGQVLLGGGDDGSLSIWG 85

  Fly   420 LNQSYCRGKSFYRRYPQKRCPWELNNCANQEEETDED--------------SSDEDVKCSEEERR 470
            |::|..|.....:....||    ||....|..::|::              :.:..::.....:.
Yeast    86 LDESLHRNDEGEQELINKR----LNYIKRQPHQSDDEPAQIMGYKNKRTRINDNNTMRLVHSFQT 146

  Fly   471 ERNRARHCK-----------YADNSYNEYGGF-----------QLRGHTKGVTDVR-FSAHYPLM 512
            :||:.|..:           :..|..:...||           .:..|..|:|.:: :.|...:.
Yeast   147 QRNKYRMYRQSSAAVPVQRSHISNKTDSPIGFSETLSETDSEASISHHKYGITTLKWYKADNGMF 211

  Fly   513 YSVSKDATMRCWRAHNLHCAAIYRSHNYPIWCLDESPV--GQYVVTGSKDLSARLWSLEKEHALI 575
            ::.|.|.|::.|..:... |....:..|.|..:|.:.|  ...:|..|:|...||..|...::.:
Yeast   212 FTGSNDKTVKIWDTNRFE-AVQDINLGYKINQIDNNVVDDSSLLVVASEDYYPRLIDLRTMNSGV 275

  Fly   576 IYAG------HTQDVECVAFHP-NGNYIATGSADHSVRLW------------CATSGKLMRVFAD 621
            ...|      ...::.|..|:| ....||.|..:..|:||            .....:...:..|
Yeast   276 TALGMGNQTRMQSEILCCKFNPVREQIIACGDMEGGVKLWDLRMRNRLYSELKRNKNRFKTINND 340

  Fly   622 CRQAVTQLAFSPDGKMLAAAGEETKVRIFDLAAGAQLAELKDHSASISSLSWSTHNRHLATACSD 686
            .....:.:.||.:                         :.|.|....|.:.|::....|.:...|
Yeast   341 DNDDQSDVYFSSN-------------------------QSKAHLRCCSDIVWNSEGSELCSVGMD 380

  Fly   687 GTLRLW----DIKKLSPMSDNSSAGSSSSATTNRVLTVNSSCQRLVDVFYGTSKTLYCI 741
            |.|.:|    :|.:...::..|..|:..   .:|:.......:||:    ...|.|.||
Yeast   381 GKLNVWRPFTEILQPEGLASYSQLGTQD---LSRIKYKKRVSRRLL----WFDKFLLCI 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wda	NP_651136.1	TAF5_NTD2	104..273	CDD:298747
		WD40	324..>700	CDD:225201	71/406 (17%)
		WD40	491..700	CDD:238121	43/245 (18%)
		WD40 repeat	501..537	CDD:293791	7/36 (19%)
		WD40 repeat	542..578	CDD:293791	9/37 (24%)
		WD40 repeat	585..619	CDD:293791	9/46 (20%)
		WD40 repeat	626..662	CDD:293791	2/35 (6%)
RAD28	NP_010313.3	WD40	1..386	CDD:225201	69/394 (18%)
		WD40 repeat	61..102	CDD:293791	8/40 (20%)
		WD40 repeat	108..170	CDD:293791	5/61 (8%)
		WD40 repeat	198..233	CDD:293791	7/35 (20%)
		WD40 repeat	241..279	CDD:293791	8/37 (22%)
		WD40 repeat	290..351	CDD:293791	10/60 (17%)
		WD40 repeat	362..388	CDD:293791	7/25 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900