DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wda and TAF5

DIOPT Version :9

Sequence 1:	NP_651136.1	Gene:	wda / 42750	FlyBaseID:	FBgn0039067	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_197897.3	Gene:	TAF5 / 832586	AraportID:	AT5G25150	Length:	669	Species:	Arabidopsis thaliana

Alignment Length:	732	Identity:	175/732 - (23%)
Similarity:	296/732 - (40%)	Gaps:	162/732 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 SDFLL--LQNKQQFAVNKMLDTDLH---GGNSFT---FSNVQVITNNQHTVDQQ----------F 107
            ::|::  |:.|...:..|.|::..|   .|:|||   :.|...:|....:..||          :
plant     7 NEFVVGYLKKKGFSSAAKDLESYHHQNNNGSSFTSVDYHNDPELTKLIRSFSQQEDDPTRYREGY 71

  Fly   108 GRFSQFVEAQAEPLRLEMKRFYGPMLCHFYLDLL---KAREPRGAVELLRKYAHLVAPVDMYDAP 169
            .:...:.....:..:.|:.|...|:..|.|:||:   ..:|.|......||...:|...|:
plant    72 SKLRSWAYNSLDLYKHELLRVMYPVFIHCYMDLVGKGHTQEARAFFNSFRKDHEMVHLRDL---- 132

  Fly   170 PPTKINGC-----------STTANESTFNIRFAKEAQDTGDTELDYFMRLVQTL----------- 212
              .|:.|.           :.:..:|..||:|   .|.:.:..|.|....|.||
plant   133 --QKLEGVLSPSHLEEMEFARSLRKSKVNIKF---CQYSYELLLQYLHSTVSTLMLGIINEHINF 192

  Fly   213 SGYTRLEAAESDDTVAHFRSSKYELHTTAVVVNRICAYLQRRGHVLIMNLLYTWLHVHIVENEQR 277
            ..|:....:.|||..|               |..:.::.....|:....:.:..|...:   |.|
plant   193 QVYSGQPTSSSDDIEA---------------VTIVGSFQDTANHINQKEIQWGLLEDSL---EDR 239

  Fly   278 AFSEDHLLGLTDDLEGE--DGEDDVVSKPAVTLNTRGD----IRPSK--SLTEKSNR-------K 327
            ......||..::..:||  ||:.|...|.:..:..:|.    ::..|  :.|.|..|       .
plant   240 LEKTGGLLSDSEKGQGESKDGDADDSKKRSTEIGKQGSSLKKLKKDKAGNATAKVARLETITVSP 304

  Fly   328 RPAEEPNI---MLETDIKQEVETDESAELSKLQLNIDACLDTLKSATEQILKSQVELP--RFLRI 387
            .|..:|.:   ::.||::|.:                     |:....::..|.|.:|  .|...
plant   305 APRVKPELALPVMSTDVEQSI---------------------LEDLRNRVQLSSVAMPSVSFYTF 348

  Fly   388 SERSRGLTSAHLDPSECHMLAGFDNSAVQLWQLNQSYCRGKSFYRRYPQKRCPWELNNCANQEEE 452
            .....||..:.:......:..||.:|::::|.:.                    ::....:...:
plant   349 VNTHNGLNCSSISHDGSLVAGGFSDSSIKVWDMA--------------------KIGQAGSGALQ 393

  Fly   453 TDEDSSDEDVKCSEEERRERNRARHCKYADNSYNEYGGFQLRGHTKGVTDVRFSAHYPLMYSVSK 517
            .:.||||:.:  ....||             ||.     .|.||:..|....||.....:.|.|.
plant   394 AENDSSDQSI--GPNGRR-------------SYT-----LLLGHSGPVYSATFSPPGDFVLSSSA 438

  Fly   518 DATMRCWRAH---NLHCAAIYRSHNYPIWCLDESPVGQYVVTGSKDLSARLWSLEKEHALIIYAG 579
            |.|:|.|...   ||.|   |:.||||:|....||.|.|..:.|.|.:||:||:::...|.|.||
plant   439 DTTIRLWSTKLNANLVC---YKGHNYPVWDAQFSPFGHYFASCSHDRTARIWSMDRIQPLRIMAG 500

  Fly   580 HTQDVECVAFHPNGNYIATGSADHSVRLWCATSGKLMRVFADCRQAVTQLAFSPDGKMLAAAGEE 644
            |..||:||.:|||.|||||||:|.:||||...:|:.:|:|...|..|..||.||||:.:|:..|:
plant   501 HLSDVDCVQWHPNCNYIATGSSDKTVRLWDVQTGECVRIFIGHRSMVLSLAMSPDGRYMASGDED 565

  Fly   645 TKVRIFDLAAGAQLAELKDHSASISSLSWSTHNRHLATACSDGTLRLWDI---KKLSPMSDNSSA 706
            ..:.::||:....:..|..|::.:.|||:|.....||:..:|.|::|||:   .||:...:.:
plant   566 GTIMMWDLSTARCITPLMGHNSCVWSLSYSGEGSLLASGSADCTVKLWDVTSSTKLTKAEEKN-- 628

  Fly   707 GSSSSATTNRVLTVNSS 723
            |:|:...:.|.....|:
plant   629 GNSNRLRSLRTFPTKST 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wda	NP_651136.1	TAF5_NTD2	104..273	CDD:298747	35/203 (17%)
		WD40	324..>700	CDD:225201	110/393 (28%)
		WD40	491..700	CDD:238121	85/214 (40%)
		WD40 repeat	501..537	CDD:293791	12/38 (32%)
		WD40 repeat	542..578	CDD:293791	13/35 (37%)
		WD40 repeat	585..619	CDD:293791	19/33 (58%)
		WD40 repeat	626..662	CDD:293791	11/35 (31%)
TAF5	NP_197897.3	TFIID_NTD2	64..188	CDD:398277	25/132 (19%)
		WD40 repeat	357..416	CDD:293791	13/98 (13%)
		WD40	414..663	CDD:238121	89/237 (38%)
		WD40 repeat	422..458	CDD:293791	12/38 (32%)
		WD40 repeat	463..499	CDD:293791	13/35 (37%)
		WD40 repeat	506..541	CDD:293791	19/34 (56%)
		WD40 repeat	547..583	CDD:293791	11/35 (31%)
		WD40 repeat	589..622	CDD:293791	12/32 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D620721at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19879
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.980