DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wda and TEP1

DIOPT Version :9

Sequence 1:	NP_651136.1	Gene:	wda / 42750	FlyBaseID:	FBgn0039067	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_009041.2	Gene:	TEP1 / 7011	HGNCID:	11726	Length:	2627	Species:	Homo sapiens

Alignment Length:	454	Identity:	97/454 - (21%)
Similarity:	145/454 - (31%)	Gaps:	157/454 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   383 RFLRISERSRGLTSAHLDP--------SECHMLAGFDNSAVQLWQLNQSYCRGKSFYRRYPQKRC 439
            |..:||..|:|.....||.        |...:::|.::.::|.|.|.:  |..:|.
Human  1952 RIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKE--CSLQSL--------- 2005

  Fly   440 PWELN-------NCANQEEETDEDSSD-----------------EDVKCSEEERRERNRARHCKY 480
             |.|:       ..|..:|.....|.|                 ||..|..|.|........|.:
Human  2006 -WLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSF 2069

  Fly   481 A-----------------------------------------------DN---SYNEYGGF---- 491
            :                                               ||   |.:..|..
Human  2070 STDGGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWD 2134

  Fly   492 --------QLRGHTKGVTDVRFSAHYPLMYSVSKDATMRCW----------RAHN---LHCAAIY 535
                    |..||...|:.|  :|....:.|||:|.|::.|          .||:   .||||
Human  2135 PESGQRLGQFLGHQSAVSAV--AAVEEHVVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCAA-- 2195

  Fly   536 RSHNYPIWCLDESPVGQ-----YVVTGSKDLSARLWSLEKEHALII-----YAGHTQDVECVAFH 590
                    .::....||     .|||...|.:.|||     |.|::     ..||:..|...|..
Human  2196 --------AMEPRAAGQPGSELLVVTVGLDGATRLW-----HPLLVCQTHTLLGHSGPVRAAAVS 2247

  Fly   591 PNGNYIATGSADHSVRLWCATSGKLMRVFADCRQAVTQLAFSPDGKMLAAAGEETKVRIFDLAAG 655
            .....:.|.|.|.|||||................|||.:|::|||.|..:..:..::.::..|..
Human  2248 ETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGELILWQEAKA 2312

  Fly   656 AQLAELKDHSASISSLSWST-HNRHLATACSDGTLRLWDIKKLSPMSDNSSAGSSSSATTNRVL 718
            ...|:...|   |.:|.||: |...:.:|  |..:..|.:|     ....||..:.|...||:|
Human  2313 VATAQAPGH---IGALIWSSAHTFFVLSA--DEKISEWQVK-----LRKGSAPGNLSLHLNRIL 2366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wda	NP_651136.1	TAF5_NTD2	104..273	CDD:298747
		WD40	324..>700	CDD:225201	91/434 (21%)
		WD40	491..700	CDD:238121	61/244 (25%)
		WD40 repeat	501..537	CDD:293791	14/48 (29%)
		WD40 repeat	542..578	CDD:293791	11/45 (24%)
		WD40 repeat	585..619	CDD:293791	9/33 (27%)
		WD40 repeat	626..662	CDD:293791	9/35 (26%)
TEP1	NP_009041.2	TEP1 N-terminal 1	1..30
		TEP1_N	1..29	CDD:283129
		TEP1 N-terminal 2	31..60
		TEP1_N	31..59	CDD:283129
		TEP1 N-terminal 3	61..90
		TEP1_N	61..89	CDD:283129
		TEP1 N-terminal 4	91..120
		TEP1_N	91..119	CDD:283129
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	193..214
		TROVE	226..676	CDD:283406
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..402
		DUF4062	908..1008	CDD:290011
		NACHT	1162..1337	CDD:283404
		WD 1	1411..1448
		WD 2	1674..1713
		WD40	1680..1955	CDD:295369	1/2 (50%)
		WD40	<1680..1824	CDD:225201
		WD40 repeat	1680..1716	CDD:293791
		WD 3	1716..1754
		WD40 repeat	1722..1757	CDD:293791
		WD 4	1757..1796
		WD40 repeat	1762..1801	CDD:293791
		WD 5	1798..1837
		WD40	1799..2190	CDD:225201	44/251 (18%)
		WD40 repeat	1804..1840	CDD:293791
		WD 6	1840..1879
		WD40 repeat	1845..1881	CDD:293791
		WD 7	1882..1921
		WD40 repeat	1888..1923	CDD:293791
		WD 8	1925..1964		5/11 (45%)
		WD 9	1967..2005		8/39 (21%)
		WD40	1972..2308	CDD:238121	72/364 (20%)
		WD40 repeat	1972..2013	CDD:293791	9/52 (17%)
		WD 10	2008..2047		5/38 (13%)
		WD40 repeat	2016..2059	CDD:293791	8/42 (19%)
		WD40	2022..2391	CDD:225201	80/372 (22%)
		WD 11	2059..2098		1/38 (3%)
		WD40 repeat	2064..2103	CDD:293791	1/38 (3%)
		WD 12	2105..2143		4/37 (11%)
		WD40 repeat	2111..2145	CDD:293791	5/33 (15%)
		WD 13	2146..2183		11/38 (29%)
		WD40 repeat	2151..2235	CDD:293791	26/100 (26%)
		WD 14	2185..2233		17/62 (27%)
		WD40	2231..>2391	CDD:295369	38/146 (26%)
		WD 15	2236..2275		12/38 (32%)
		WD40 repeat	2241..2280	CDD:293791	10/38 (26%)
		WD 16	2278..2317		9/38 (24%)
		WD40 repeat	2283..2307	CDD:293791	7/23 (30%)
		WD 17	2319..2355		11/45 (24%)
		WD40 repeat	2326..2359	CDD:293791	9/39 (23%)
		WD 18	2368..2417
		WD40 repeat	2372..2418	CDD:293791
		WD 19	2459..2500
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2506..2551
		WD 20	2553..2590
		WD 21	2592..2626
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900