DRSC/TRiP Functional Genomics Resources

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Protein Alignment wda and TAF5

DIOPT Version :10

Sequence 1:NP_651136.1 Gene:wda / 42750 FlyBaseID:FBgn0039067 Length:743 Species:Drosophila melanogaster
Sequence 2:NP_008882.2 Gene:TAF5 / 6877 HGNCID:11539 Length:800 Species:Homo sapiens


Alignment Length:655 Identity:164/655 - (25%)
Similarity:269/655 - (41%) Gaps:112/655 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 DQQFGRFSQFVEAQAEPLRLEMKRFYGPMLCHFYLDLLKAREPRGAVELLRKYAHLVAPVDMYDA 168
            ::.:.....|:|...:..|.|:.:.:.|:..|.||:|:..:....|.....|: |          
Human   215 EEYYSGLKHFIECSLDCHRAELSQLFYPLFVHMYLELVYNQHENEAKSFFEKF-H---------- 268

  Fly   169 PPPTKINGCSTTANESTFNIRFAKEAQDTGDTELDYFMRLVQTLSGYTRLEAAESDDTVAHFRSS 233
                                         ||.|. |:...::.||..|:.|..:.::|:..||:|
Human   269 -----------------------------GDQEC-YYQDDLRVLSSLTKKEHMKGNETMLDFRTS 303

  Fly   234 KYELHTTAVVVNRICAYLQRRGHVLIMNLLYTWLHVHIVENEQRAFSEDHLLGLTDDLEGEDGED 298
            |:.|..:......:..:||.:.:..|.|::...|::.|.:...|  |:..:..:...|.||...:
Human   304 KFVLRISRDSYQLLKRHLQEKQNNQIWNIVQEHLYIDIFDGMPR--SKQQIDAMVGSLAGEAKRE 366

  Fly   299 --------DVVSKPAVTL----------NTRGDIRPSKSLTEKSNRKRPAEEPNIMLETDIKQEV 345
                    .::.:|.:.:          |..|..:..|...:....|...::||...:..|... 
Human   367 ANKSKVFFGLLKEPEIEVPLDDEDEEGENEEGKPKKKKPKKDSIGSKSKKQDPNAPPQNRIPLP- 430

  Fly   346 ETDESAELSKLQLNIDACLDTLKSATEQILKSQVELPR--FLRISERSRGLTSAHLDPSECHMLA 408
            |..:|.:|.|:.        .:|..|:::......||.  |.......:|||:..:......:..
Human   431 ELKDSDKLDKIM--------NMKETTKRVRLGPDCLPSICFYTFLNAYQGLTAVDVTDDSSLIAG 487

  Fly   409 GFDNSAVQLWQLNQSYCRGKSFYRRYPQKRCPWELNNCANQEEETDEDSSDEDVKCSEEERRERN 473
            ||.:|.|::|.:.                  |.:|.:.....:.:..|...:||.   |...:..
Human   488 GFADSTVRVWSVT------------------PKKLRSVKQASDLSLIDKESDDVL---ERIMDEK 531

  Fly   474 RARHCKYADNSYNEYGGFQLRGHTKGVTDVRFSAHYPLMYSVSKDATMRCWRAHNLHCAAIYRSH 538
            .|...|.            |.||:..|....||.....:.|.|:|.|:|.|......|...|:.|
Human   532 TASELKI------------LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGH 584

  Fly   539 NYPIWCLDESPVGQYVVTGSKDLSARLWSLEKEHALIIYAGHTQDVECVAFHPNGNYIATGSADH 603
            |||:|....||.|.|.|:|..|..||||:.:....|.|:|||..||.|..||||.||:||||||.
Human   585 NYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADR 649

  Fly   604 SVRLWCATSGKLMRVFADCRQAVTQLAFSPDGKMLAAAGEETKVRIFDLAAGAQLAELKDHSASI 668
            :||||...:|..:|:|...:..:..|.|||:|:.||....:.:|.::|:..|..:.|||.|:.::
Human   650 TVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTV 714

  Fly   669 SSLSWSTHNRHLATACSDGTLRLWD-IKKLSPMSDNSSAGSSSSATTNRVLTVNSSCQRLVDVFY 732
            .||.:|.....||:...|.|:|||| ||....:..:    ..::||.:..|..||  |.|:...|
Human   715 CSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETD----DFTTATGHINLPENS--QELLLGTY 773

  Fly   733 GTSKT 737
            .|..|
Human   774 MTKST 778

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wdaNP_651136.1 TAF5_NTD2 104..273 CDD:471824 32/168 (19%)
WD40 <493..695 CDD:441893 82/202 (41%)
WD40 repeat 501..537 CDD:293791 10/35 (29%)
WD40 repeat 542..578 CDD:293791 14/35 (40%)
WD40 repeat 585..619 CDD:293791 19/33 (58%)
WD40 repeat 626..662 CDD:293791 11/35 (31%)
TAF5NP_008882.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..74
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 153..189
NTD2, involved in homo-dimerization, also involved in TFIID-TFIIF contacts in the RNA Pol II pre-initiation complex (PIC). /evidence=ECO:0000303|PubMed:33795473, ECO:0007744|PDB:2NXP 194..340 31/165 (19%)
TFIID_NTD2 208..337 CDD:461330 30/162 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 384..438 9/54 (17%)
WD40 <456..740 CDD:441893 100/316 (32%)
WD 1. /evidence=ECO:0000255 468..507 10/56 (18%)
WD40 repeat 473..541 CDD:293791 16/100 (16%)
WD 2. /evidence=ECO:0000255 541..580 12/38 (32%)
WD40 repeat 547..583 CDD:293791 10/35 (29%)
WD 3. /evidence=ECO:0000255 583..624 18/40 (45%)
WD40 repeat 588..624 CDD:293791 14/35 (40%)
WD 4. /evidence=ECO:0000255 625..666 23/40 (58%)
WD40 repeat 631..666 CDD:293791 19/34 (56%)
WD 5. /evidence=ECO:0000255 667..706 10/38 (26%)
WD40 repeat 672..708 CDD:293791 11/35 (31%)
WD 6. /evidence=ECO:0000255 709..748 14/38 (37%)
WD40 repeat 714..756 CDD:293791 13/45 (29%)
Blue background indicates that the domain is not in the aligned region.

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