DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wda and Wdr7

DIOPT Version :9

Sequence 1:	NP_651136.1	Gene:	wda / 42750	FlyBaseID:	FBgn0039067	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_076465.1	Gene:	Wdr7 / 66031	RGDID:	619836	Length:	1488	Species:	Rattus norvegicus

Alignment Length:	737	Identity:	132/737 - (17%)
Similarity:	241/737 - (32%)	Gaps:	250/737 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 QQFAVN-----KMLDTDLHGGNSFTFSNVQVITNNQHTVDQQFGRFSQFVEAQAEPLRLEMKRFY 129
            :|:.|:     :|...|::.|....|:.:..    .|| ..||.:||  |..|.|
  Rat    79 KQYTVSASANGEMCLWDVNDGRCIEFTKLAC----THT-GIQFYQFS--VGNQRE---------- 126

  Fly   130 GPMLCH-FYLDLLKAREPRGAVELLRKYAHLVAPVDMYDAPPPTKINGCSTTANESTFNIRFAKE 193
            |.:||| .|.::|..    .|..|...|: ||:.:.      |..|:..|.        ||..:.
  Rat   127 GRLLCHGHYPEILVV----DATSLEVLYS-LVSKIS------PDWISSMSI--------IRSHRT 172

  Fly   194 AQDTGDTELDYFMRLVQTLSGYTRL-----EAAESDDTVAHFRSSKYELHTTAVVVNRICAYLQR 253
            .:||         .:..:::|..::     |.:...||...|......::.........||:.||
  Rat   173 QEDT---------VVALSVTGILKVWIVTSEISGLQDTEPIFEEESKPIYCQNCQSLSFCAFTQR 228

  Fly   254 RGHVLIMNLLY---------------------TWLHVHIVENEQRAFSEDHLLGLTDDLEGEDGE 297
              .:|::...|                     ||.....|       |.|.::..|     |:|:
  Rat   229 --SLLVVCSKYWRVFDAGDYSLLCSGPSEDGQTWTGGDFV-------SADKVIIWT-----ENGQ 279

  Fly   298 DDVVSKPAVTL----NTRGDIRPS---------KSLTEKSNRKRPAEEP-------------NIM 336
            ..:...||..|    :.|.|:..:         .||.::.:|:.....|             .::
  Rat   280 SYIYKLPASCLPASDSFRSDVGKAVENLIPPVQHSLLDQKDRELVICPPVTRFFYGCKEYLHKLL 344

  Fly   337 LE------------TDIKQEVETDESAELSKLQLNIDACLDTLKSATEQILKSQVELPRFLRISE 389
            ::            .||..:.|.:|..:.:.. :::....|.||.....|:.....:|.    |.
  Rat   345 IQGDSSGRLSIWNIADIADKQEANEGLKTTTC-ISLQDAFDKLKPCPAGIIDQLSVIPN----SN 404

  Fly   390 RSRGLTSAHLDPSECHMLAGFDNSAVQLWQLNQS----YCRGKSFYRR-YPQKRCPWELNNCANQ 449
            ....:|::...|:...::.|.::.::.:....|:    ..:|:...|| :|..|
  Rat   405 EPLKVTASVYIPAHGRLVCGREDGSIIIVPATQTAIVQLLQGEHMLRRGWPPHR----------- 458

  Fly   450 EEETDEDSSDEDVKCSEEERRERNRARHCKYADNSYNEYGGFQLRGHTKGVTDVRF----SAHYP 510
                                                      .||||...||.:.:    ||.|.
  Rat   459 ------------------------------------------TLRGHRNKVTCLLYPHQVSARYD 481

  Fly   511 LMYSVS--KDATMRCWRAHNLHCAAIYRSHNYPIWCLDESPVGQYVV--------------TGSK 559
            ..|.:|  .|.::..|        .|:......|:|:....:.|.:|              :.:.
  Rat   482 QRYLISGGVDFSVIIW--------DIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCVCSVAS 538

  Fly   560 DLSARLWSLEKEHALIIYAGHTQDVECVAFHPNGNYIATGSADHSVRLWCATSGKLMRVFADCRQ 624
            |.|..|.||.::..:::.:.|...::.:.:.|:.:|:..|..|.||.:|...:|.|.|    |..
  Rat   539 DHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCTDGSVCVWQMDTGALDR----CAM 599

  Fly   625 AVTQLAFSPDGKMLAAAGEETKVRIFDLAAGAQLAELKDHSASISSLSWSTHN-RHLATACSDGT 688
            .:|.:      ::|.|..|..                   .|::.|||....| :...|..|...
  Rat   600 GITAV------EILNACDEAV-------------------PAAVDSLSHPAVNLKQAMTRRSLAA 639

  Fly   689 LRLWDIKKLSPMSDNSSAGSSS 710
            |:.....||..::.|..|..:|
  Rat   640 LKNMAHHKLQTLATNLLASEAS 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wda	NP_651136.1	TAF5_NTD2	104..273	CDD:298747	38/195 (19%)
		WD40	324..>700	CDD:225201	70/426 (16%)
		WD40	491..700	CDD:238121	49/229 (21%)
		WD40 repeat	501..537	CDD:293791	9/41 (22%)
		WD40 repeat	542..578	CDD:293791	9/49 (18%)
		WD40 repeat	585..619	CDD:293791	10/33 (30%)
		WD40 repeat	626..662	CDD:293791	4/35 (11%)
Wdr7	NP_076465.1	WD 1	17..56
		WD40	<19..199	CDD:225201	35/164 (21%)
		WD40	<19..102	CDD:295369	5/22 (23%)
		WD40 repeat	22..62	CDD:293791
		WD 2	62..104		5/24 (21%)
		WD40 repeat	68..109	CDD:293791	6/29 (21%)
		WD40 repeat	114..153	CDD:293791	16/55 (29%)
		WD 3	156..199		9/65 (14%)
		WD40 repeat	162..208	CDD:293791	10/62 (16%)
		WD 4	324..366		3/41 (7%)
		WD40	341..>592	CDD:225201	50/316 (16%)
		WD40 repeat	393..461	CDD:293791	12/124 (10%)
		WD 5	404..443		4/38 (11%)
		WD40	407..>594	CDD:295369	41/247 (17%)
		WD 6	462..507		12/52 (23%)
		WD40 repeat	468..522	CDD:293791	13/61 (21%)
		WD 7	558..597		11/42 (26%)
		WD40 repeat	563..589	CDD:293791	7/25 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	761..781
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..947
		WD 8	1349..1388
		WD40 repeat	1354..1390	CDD:293791
		WD40	<1355..1424	CDD:295369
		WD40	<1363..>1482	CDD:225201
		WD 9	1390..1430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900