DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wda and taf5

DIOPT Version :9

Sequence 1:	NP_651136.1	Gene:	wda / 42750	FlyBaseID:	FBgn0039067	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001032508.1	Gene:	taf5 / 641491	ZFINID:	ZDB-GENE-051120-180	Length:	743	Species:	Danio rerio

Alignment Length:	657	Identity:	167/657 - (25%)
Similarity:	275/657 - (41%)	Gaps:	125/657 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 FGRFSQFVEAQAEPLRLEMKRFYGPMLCHFYLDLLKAREPRGAVELLRKYAHLVAPVDMYDAPPP 171
            :....:|:|:..:..|.|:.:.:.|:..|.||:|:.......|.....|:
Zfish   161 YSDLKKFIESVLDCHRAELSQLFYPLFVHMYLELVYNNHESEAKAFFDKF--------------- 210

  Fly   172 TKINGCSTTANESTFNIRFAKEAQDTGDTELDYFMRLVQTLSGYTRLEAAESDDTVAHFRSSKYE 236
                                     :||.|. |:...::.|.|.|:.|..:.::.:..||:|::.
Zfish   211 -------------------------SGDQEC-YYEDDLRVLCGLTKKEHMKGNEALLDFRTSRFV 249

  Fly   237 LHTTAVVVNRICAYLQRRGHVLIMNLLYTWLHVHIVENEQRAFSEDHLLGLTDDLEGE------- 294
            |..:......:..:||.|.:..|.|::...|::.|.:...|  |:..:..::..|.||
Zfish   250 LRISRDSYQLLKRHLQERQNNQIWNIIQEHLYIDIFDGMPR--SKSQIDSMSGSLAGEARREVNK 312

  Fly   295 -----------------DGEDDVVSKPAVTLNTRGDIRPSKSLTEKSN--RKRPAEEPNIMLETD 340
                             |.||:...      |..|  :|.|..|:|.:  .|...::||...:..
Zfish   313 VKVFYGLLKEPEIEVPLDDEDEEAE------NEEG--KPKKKKTKKDSMGSKSKKQDPNAPQQNR 369

  Fly   341 IKQEVETDESAELSKLQLNIDACLDTLKSATEQILKSQVELPR--FLRISERSRGLTSAHLDPSE 403
            |... |..:|.:|.|:..        :|.:|::|......||.  |.......:|||:.......
Zfish   370 IPLP-ELKDSDKLDKIMY--------MKESTKRIRLGPETLPSICFYTFLNAYQGLTAVDFTDDS 425

  Fly   404 CHMLAGFDNSAVQLWQLNQSYCRGKSFYRRYPQKRCPWELNNCANQEEETDEDSSDEDVKCSEEE 468
            ..:..||.:|.|::|.:.....|         :.:...:||....:.::..|...||  |.|.|.
Zfish   426 SLIAGGFADSTVRVWSVTPKKLR---------KVKSAADLNLIDKESDDVLERIMDE--KTSSES 479

  Fly   469 RRERNRARHCKYADNSYNEYGGFQLRGHTKGVTDVRFSAHYPLMYSVSKDATMRCWRAHNLHCAA 533
            :                      .|.||:..|..|.||.....:.|.|:|.|:|.|......|..
Zfish   480 K----------------------ILHGHSGPVYGVSFSPDRNYLLSSSEDGTIRLWSLQTFTCLV 522

  Fly   534 IYRSHNYPIWCLDESPVGQYVVTGSKDLSARLWSLEKEHALIIYAGHTQDVECVAFHPNGNYIAT 598
            .|:.||||:|....||.|.|.|:|..|..||||:.:....|.|:|||..||.|..||||.||:||
Zfish   523 GYKGHNYPVWDTQFSPFGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVTCTRFHPNSNYVAT 587

  Fly   599 GSADHSVRLWCATSGKLMRVFADCRQAVTQLAFSPDGKMLAAAGEETKVRIFDLAAGAQLAELKD 663
            ||:|.:||||...:|..:|:|...:..:..|||||:||.||:...:.:|.::|:..|..:||||.
Zfish   588 GSSDRTVRLWDVLNGNCVRIFTGHKGPIHSLAFSPNGKFLASGSTDGRVLLWDIGHGLMIAELKG 652

  Fly   664 HSASISSLSWSTHNRHLATACSDGTLRLWDIKKLSPMSDNSSAGSSSSATTNRVLTVNSSCQRLV 728
            |:.:|.:|.:|.....:|:...|.|:||||:.:   ..|:......::||.:..|..||. :.|:
Zfish   653 HTGTIYALKFSRDGEIIASGSIDNTVRLWDVMR---AIDDVETDDFTAATGHIHLPDNSQ-ELLL 713

  Fly   729 DVFYGTS 735
            ..::..|
Zfish   714 GTYHSKS 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wda	NP_651136.1	TAF5_NTD2	104..273	CDD:298747	30/165 (18%)
		WD40	324..>700	CDD:225201	115/379 (30%)
		WD40	491..700	CDD:238121	84/208 (40%)
		WD40 repeat	501..537	CDD:293791	11/35 (31%)
		WD40 repeat	542..578	CDD:293791	14/35 (40%)
		WD40 repeat	585..619	CDD:293791	18/33 (55%)
		WD40 repeat	626..662	CDD:293791	14/35 (40%)
taf5	NP_001032508.1	TAF5_NTD2	154..286	CDD:176269	30/165 (18%)
		WD40	<392..683	CDD:225201	104/323 (32%)
		WD40	415..682	CDD:238121	99/299 (33%)
		WD40 repeat	416..484	CDD:293791	17/100 (17%)
		WD40 repeat	490..526	CDD:293791	11/35 (31%)
		WD40 repeat	531..567	CDD:293791	14/35 (40%)
		WD40 repeat	574..609	CDD:293791	18/34 (53%)
		WD40 repeat	615..651	CDD:293791	14/35 (40%)
		WD40 repeat	657..683	CDD:293791	9/25 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D230914at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19879
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020