DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wda and taf5l

DIOPT Version :9

Sequence 1:	NP_651136.1	Gene:	wda / 42750	FlyBaseID:	FBgn0039067	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001006779.1	Gene:	taf5l / 448469	XenbaseID:	XB-GENE-998039	Length:	588	Species:	Xenopus tropicalis

Alignment Length:	701	Identity:	176/701 - (25%)
Similarity:	295/701 - (42%)	Gaps:	143/701 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LRCAVGLLLKQKNYVSNERFRRSDFLLLQNKQQFAVNKMLDTDLHGGNSFTFSNVQVITNNQHTV 103
            ::.||...||:::|:..|...:....|.|..::.|.|..:..:....|:  .|:|. .:.:.|..
Frog     9 IQLAVTCYLKRRHYIDIEGSLKQGLRLCQTAEEMAANLTVQAESSCTNA--VSSVP-CSPDAHQY 70

  Fly   104 DQQFGRFSQFVEAQAEPLRLEMKRFYGPMLCHFYLDLLKAREPRGAVELLRKYAHLVAPVDMYDA 168
            :.||.|...|:.....|...|:.....|:..:.:||:::              ..|.:.||.:
Frog    71 EVQFARLRNFLSDADSPHSQEVTTLLYPLFVYLHLDMVQ--------------NSLKSAVDSF-- 119

  Fly   169 PPPTKINGCSTTANESTFNIRFAKEAQDTGDTELDYFMRLVQTLSGYTRLEAAESDDTVAHFRSS 233
                          .|.|:..|   .|..|..:      :|:.|.....::...|:..:..|..:
Frog   120 --------------YSRFHGMF---MQHPGQRD------IVEQLQTTMTMQDIHSNCKLRAFLDN 161

  Fly   234 KYELHTTAVVVNRICAYLQRRGHVLIMNLLYTWLHVHIVENEQRAFSEDHLLGLTDDLEGEDGED 298
            ||.          :|  ||...:..::..|                               ..::
Frog   162 KYV----------VC--LQEDSYHYLLRFL-------------------------------QSDN 183

  Fly   299 DVVSKPAVTLNTRGDIRPSKSLTE----KSNRKRPAEEPNIMLETDIKQEVETDESAELSKLQLN 359
            :.....|:.|:.:.|::|.|. ||    .|.......|.|.:.::|:...:..:|:| |.:||
Frog   184 NTALCKALALHIQLDVQPVKR-TEYQLYNSMGSSSRGENNSLDQSDVPTPILQNEAA-LDQLQ-- 244

  Fly   360 IDACLDTLKSATEQILKSQVELPRFLRISERSRGLTSAHLDPSECHMLAGFDNSAVQLWQLNQSY 424
              .|:..:|.....:....     |.......:.|.:|.:.|....:.||||:|.|:||.|....
Frog   245 --DCIKKVKDGPPSLTTIS-----FYAFYNTEQLLNTAEISPDSRLLAAGFDSSCVKLWSLKSKK 302

  Fly   425 CRGKSFYRRYPQKRCPWELNNCANQEEETDEDSSDEDVKCSEEERRERNRARHCKYADNSYNEYG 489
            .:.:.......:.|..     |...|||.||.:..| :|.
Frog   303 LKAEPHRVDVSRIRLA-----CDVLEEEEDEQAGTE-MKI------------------------- 336

  Fly   490 GFQLRGHTKGVTDVRFSAHYPLMYSVSKDATMRCWRAHNLHCAAIYRSHNYPIWCLDESPVGQYV 554
               ||||:..|....|.:....:.|.|:|.::|.|...|.....:|:.|.:|:|.||.||...:.
Frog   337 ---LRGHSGPVYRTCFLSDSSGLLSCSEDTSIRYWNLENFTNTVLYQGHAHPVWDLDVSPCSLFF 398

  Fly   555 VTGSKDLSARLWSLEKEHALIIYAGHTQDVECVAFHPNGNYIATGSADHSVRLWCATSGKLMRVF 619
            .:.|.|.:.|||..::...|.|||||..||:|:.||||.||:||||.|.:||||....|..:|:|
Frog   399 ASASHDRTGRLWCFDRTFPLRIYAGHLSDVDCIKFHPNSNYLATGSTDKTVRLWSTQQGNSVRLF 463

  Fly   620 ADCRQAVTQLAFSPDGKMLAAAGEETKVRIFDLAAGAQLAELKDHSASISSLSWSTHNRHLATAC 684
            ...|..|..|||||:||.||:|||:.:::::|||:|....||:.|:.:||||::|..:..:|:|.
Frog   464 TGHRGPVLALAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNISSLTFSPDSSLIASAS 528

  Fly   685 SDGTLRLWDIKKLSPMSDNSSAGSSS------SATTNRVLTVN-SSCQRLV 728
            .|.::|:|||:  :...:..|.||||      :..|:.:|:|. .:|..|:
Frog   529 MDNSVRVWDIR--NSYCNTPSDGSSSELVGVYTGQTSNILSVQFMACNLLM 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wda	NP_651136.1	TAF5_NTD2	104..273	CDD:298747	27/168 (16%)
		WD40	324..>700	CDD:225201	118/375 (31%)
		WD40	491..700	CDD:238121	85/208 (41%)
		WD40 repeat	501..537	CDD:293791	8/35 (23%)
		WD40 repeat	542..578	CDD:293791	12/35 (34%)
		WD40 repeat	585..619	CDD:293791	18/33 (55%)
		WD40 repeat	626..662	CDD:293791	18/35 (51%)
taf5l	NP_001006779.1	TAF5_NTD2	69..201	CDD:176269	30/213 (14%)
		WD40	<256..406	CDD:225201	44/188 (23%)
		WD40 repeat	274..339	CDD:293791	21/98 (21%)
		WD40	333..580	CDD:238121	97/276 (35%)
		WD40 repeat	345..381	CDD:293791	8/35 (23%)
		WD40 repeat	386..422	CDD:293791	12/35 (34%)
		WD40 repeat	429..464	CDD:293791	18/34 (53%)
		WD40 repeat	470..506	CDD:293791	18/35 (51%)
		WD40 repeat	512..559	CDD:293791	17/48 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D230914at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19879
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5404
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020