DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wda and taf5l

DIOPT Version :9

Sequence 1:	NP_651136.1	Gene:	wda / 42750	FlyBaseID:	FBgn0039067	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_956146.1	Gene:	taf5l / 334055	ZFINID:	ZDB-GENE-030131-5987	Length:	601	Species:	Danio rerio

Alignment Length:	707	Identity:	186/707 - (26%)
Similarity:	297/707 - (42%)	Gaps:	134/707 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KNDLLRCAVGLLLKQKNYVSNERFRRSDFLLLQNKQQFAVNKMLDTDLHGGNSFTFSNVQVITNN 99
            :.:.::.||...||::.|:..:...:. ..|.|..::.|.:..:.|:....|..:.:..|.   :
Zfish     5 RTEQIQYAVTQYLKRRQYIDTDGSMKG-AKLSQTAEEMAASLTVQTESSCANVVSAAPCQA---D 65

  Fly   100 QHTVDQQFGRFSQFVEAQAEPLRLEMKRFYGPMLCHFYLDLLKAREPRGAVELLRKYAHLVAPVD 164
            ....:.||.|...|::....||..|......|:.  .||.|..||
Zfish    66 PQQYENQFSRLRSFLQEAEGPLVKEASSVLFPLF--LYLHLHMAR-------------------- 108

  Fly   165 MYDAPPPTKINGCSTTANESTFNIRFAKEAQDTGDTELDYFMRLVQTLSGYTRLEAAESDDTVAH 229
                        |.......:|..||....|...:.:     .:|..|.|...|:...::..:..
Zfish   109 ------------CGLKGALDSFYSRFHSLFQQDPEQK-----AIVDLLRGALTLQDVTTNPKLCA 156

  Fly   230 FRSSKYELHTTAVVVNRICAYLQRRGHVLIMNLLYTWLHVHIVENEQRAFSEDHLLGLTDDLEGE 294
            ....||.:|.|....:.:..|||...:..|..:|...|.|.:...::   ::..|.|
Zfish   157 LLDHKYVVHLTDQAYSYLLRYLQSEDNSAICWVLTAHLQVEVTAAQR---TDYQLYG-------- 210

  Fly   295 DGEDDVVSKPAVTLNTRGDIRPSKSLTEKSNRKRPAEEPNIMLETDIKQEVETDESAELSKLQLN 359
                       ..:.| |:...|.|.|..|                    |:..|.||..::...
Zfish   211 -----------AGVGT-GNTSSSSSSTWAS--------------------VDGSEGAERLEVPAG 243

  Fly   360 I---DACLDTLKSATEQILKSQVELPR--FLRISERSRGLTSAHLDPSECHMLAGFDNSAVQLWQ 419
            :   :|.|:.|:...:::.:....|..  |.......:.|.:|.:......:.||||||||:||.
Zfish   244 LPQNEAALENLQDCIKRVREGPPSLTTVCFYAFQHTEQLLNTAEVSADSRLLAAGFDNSAVKLWS 308

  Fly   420 LNQSYCRGKSFYRRYPQKRCPWELNNCAN--QEEETDEDSSDEDVKCSEEERRERNRARHCKYAD 482
            |     |.:.. :..|.|....::....:  :||..|||:|..::|
Zfish   309 L-----RARKL-KAGPHKADVSKIRLACDVLEEEADDEDASGSEIK------------------- 348

  Fly   483 NSYNEYGGFQLRGHTKGVTDVRFSAHYPLMYSVSKDATMRCWRAHNLHCAAIYRSHNYPIWCLDE 547
                     .||||:..|....|......:.|.|:|:|:|.|...:.....:||.|.||:|.:|.
Zfish   349 ---------TLRGHSGPVYRTAFLTDASGLLSCSEDSTVRYWDLKSFTNTVLYRGHAYPVWDVDV 404

  Fly   548 SPVGQYVVTGSKDLSARLWSLEKEHALIIYAGHTQDVECVAFHPNGNYIATGSADHSVRLWCATS 612
            ||...|..|.|.|.:|||||..:.:.|.:||||..||:||.||||.|||||||.|.:||||....
Zfish   405 SPCSLYFSTASHDRTARLWSFARTYPLRLYAGHLSDVDCVKFHPNSNYIATGSTDKTVRLWSTRQ 469

  Fly   613 GKLMRVFADCRQAVTQLAFSPDGKMLAAAGEETKVRIFDLAAGAQLAELKDHSASISSLSWSTHN 677
            |..:|:|...|..|..|||||:||.||:|||:.:::::|||:|....:|:.|:.:|||||:|..:
Zfish   470 GASVRLFTGHRGPVLTLAFSPNGKYLASAGEDQRLKLWDLASGGLFKDLRGHTDTISSLSFSQDS 534

  Fly   678 RHLATACSDGTLRLWDIKKL--SPMSDNSSA---GSSSSATTNRVLTVN-SSCQRLV 728
            ..:|:|..|.|:|:|||:..  |..:|..|:   |..:.:|:| :|.|. .:|..|:
Zfish   535 SLVASASMDNTVRVWDIRNAHGSAPTDGCSSELIGQYTGSTSN-ILNVQFMACNLLL 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wda	NP_651136.1	TAF5_NTD2	104..273	CDD:298747	33/168 (20%)
		WD40	324..>700	CDD:225201	126/384 (33%)
		WD40	491..700	CDD:238121	93/210 (44%)
		WD40 repeat	501..537	CDD:293791	8/35 (23%)
		WD40 repeat	542..578	CDD:293791	14/35 (40%)
		WD40 repeat	585..619	CDD:293791	20/33 (61%)
		WD40 repeat	626..662	CDD:293791	17/35 (49%)
taf5l	NP_956146.1	TAF5_NTD2	66..200	CDD:176269	33/172 (19%)
		WD40	<227..581	CDD:225201	132/408 (32%)
		WD40	289..593	CDD:238121	123/337 (36%)
		WD40 repeat	357..394	CDD:293791	9/36 (25%)
		WD40 repeat	400..436	CDD:293791	15/35 (43%)
		WD40 repeat	441..477	CDD:293791	21/35 (60%)
		WD40 repeat	484..519	CDD:293791	16/34 (47%)
		WD40 repeat	525..572	CDD:293791	18/46 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596871
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D230914at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108737
Panther	1	1.100	-	-	O	PTHR19879
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5404
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850