DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wda and APAF1

DIOPT Version :9

Sequence 1:	NP_651136.1	Gene:	wda / 42750	FlyBaseID:	FBgn0039067	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_863651.1	Gene:	APAF1 / 317	HGNCID:	576	Length:	1248	Species:	Homo sapiens

Alignment Length:	582	Identity:	120/582 - (20%)
Similarity:	210/582 - (36%)	Gaps:	163/582 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 CHF----------------YLDL--LKAREPRGAVELLRKYAHLVAPVDMYDAPPPTKINGCS-- 178
            |||                :|.|  |..:|.|..:     :.|..:......:|....:..||
Human   705 CHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTM-----FGHTNSVNHCRFSPDDKLLASCSAD 764

  Fly   179 --------TTANE-STFNIR-FAKEAQDTGDTELDYFMRLVQTLSGYTRLEAAESDDT------- 226
                    |:||| .:.|:: |....:|..: :::..::.....:...|:..|..:..
Human   765 GTLKLWDATSANERKSINVKQFFLNLEDPQE-DMEVIVKCCSWSADGARIMVAAKNKIFLFDIHT 828

  Fly   227 --------VAHFRSSKY-----ELHTTAVVVNRICAYLQR----------RGHVLIMNLLYTWLH 268
                    ..|..:.:|     :.|...|.:::.|..|..          |||:       :|:|
Human   829 SGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHL-------SWVH 886

  Fly   269 VHIVENEQRAF---SEDHLLGLTDDLEGEDGEDDVVSKPAVTLNTRGDIRPSKSLTEKSNRKRPA 330
            ..:...:..:|   |:|..:.|.:                                    .|:..
Human   887 GVMFSPDGSSFLTSSDDQTIRLWE------------------------------------TKKVC 915

  Fly   331 EEPNIMLETDIKQEVE-TDESAELSKLQLNIDACLDTLKSATEQILKSQVELPRFLRISERSRGL 394
            :...:||    ||||: ..:..|:..|.::....|..:...|.||        .:|..::.|...
Human   916 KNSAVML----KQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQI--------DYLTEAQVSCCC 968

  Fly   395 TSAHLDPSECHMLAGFDNSAVQLWQLNQSYCRGKSFYRRYPQKRCPWELNNCANQEEETDEDSSD 459
            .|.||.    ::..|.:|.|:::.:|    ...:.|..|:..|:..|.:...|  :|:|...|||
Human   969 LSPHLQ----YIAFGDENGAIEILEL----VNNRIFQSRFQHKKTVWHIQFTA--DEKTLISSSD 1023

  Fly   460 EDVKCSEEERRERN-RARHCKYADNSYNEYGGFQLRGHTKGVTDVRFSAHYPLMYSVSKDATMRC 523
                  :.|.:..| :...|.:            ||||.:.|.|.|...:..|: |.|.|.|::.
Human  1024 ------DAEIQVWNWQLDKCIF------------LRGHQETVKDFRLLKNSRLL-SWSFDGTVKV 1069

  Fly   524 WRAHNLHCAAIYRSHNYPIWCLDESPVGQYVVTGSKDLSARLWSLEKEHALIIYAGHTQDVECVA 588
            |.....:....:..|...:...|.|.......:.|.|.:|::||.:....|....||...|.|.|
Human  1070 WNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1134

  Fly   589 FHPNGNYIATGSADHSVRLWCATSGKLMRVFADCRQA--------VTQLAFSPDGKMLAAAG 642
            |..:...:|||..:..:|:|..::|:|:.:.|...:.        ||.|.||||||||.:||
Human  1135 FSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wda	NP_651136.1	TAF5_NTD2	104..273	CDD:298747	32/198 (16%)
		WD40	324..>700	CDD:225201	84/329 (26%)
		WD40	491..700	CDD:238121	49/160 (31%)
		WD40 repeat	501..537	CDD:293791	8/35 (23%)
		WD40 repeat	542..578	CDD:293791	8/35 (23%)
		WD40 repeat	585..619	CDD:293791	10/33 (30%)
		WD40 repeat	626..662	CDD:293791	13/17 (76%)
APAF1	NP_863651.1	CARD_APAF1	7..92	CDD:260034
		NB-ARC	129..374	CDD:395745
		APAF1_C	453..587	CDD:407760
		WD40	607..910	CDD:238121	36/217 (17%)
		WD 1-1	613..652
		WD40 repeat	623..655	CDD:293791
		WD 1-2	655..694
		WD40 repeat	660..697	CDD:293791
		WD 1-3	697..738		8/32 (25%)
		WD40 repeat	703..741	CDD:293791	8/40 (20%)
		WD 1-4	741..780		8/38 (21%)
		WD40 repeat	746..791	CDD:293791	9/44 (20%)
		WD 1-5	796..836		2/39 (5%)
		WD40 repeat	802..870	CDD:293791	8/67 (12%)
		WD 1-6	838..877		6/38 (16%)
		WD 1-7	880..910		8/36 (22%)
		WD40 repeat	885..939	CDD:293791	13/93 (14%)
		Interpropeller linker. /evidence=ECO:0000250	910..921		1/46 (2%)
		WD 2-1	922..958		11/47 (23%)
		WD 2-2	959..998		10/46 (22%)
		WD40	961..1234	CDD:238121	70/265 (26%)
		WD40 repeat	964..990	CDD:293791	7/29 (24%)
		WD 2-3	1001..1040		11/58 (19%)
		WD40 repeat	1006..1030	CDD:293791	8/31 (26%)
		WD 2-4	1042..1080		11/38 (29%)
		WD40 repeat	1047..1082	CDD:293791	9/35 (26%)
		WD 2-5	1083..1122		9/38 (24%)
		WD40 repeat	1089..1124	CDD:293791	8/34 (24%)
		WD 2-6	1125..1164		13/38 (34%)
		WD40 repeat	1130..1172	CDD:293791	12/41 (29%)
		WD 2-7	1175..1212		13/22 (59%)
		WD40 repeat	1180..1213	CDD:293791	13/17 (76%)
		WD 2-8	1213..1248
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810