DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wda and Taf5

DIOPT Version :9

Sequence 1:	NP_651136.1	Gene:	wda / 42750	FlyBaseID:	FBgn0039067	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001099835.1	Gene:	Taf5 / 294018	RGDID:	1311332	Length:	798	Species:	Rattus norvegicus

Alignment Length:	655	Identity:	164/655 - (25%)
Similarity:	269/655 - (41%)	Gaps:	112/655 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 DQQFGRFSQFVEAQAEPLRLEMKRFYGPMLCHFYLDLLKAREPRGAVELLRKYAHLVAPVDMYDA 168
            ::.:.....|:|...:..|.|:.:.:.|:..|.||:|:..:....|.....|: |
  Rat   213 EEYYSGLKHFIECSLDCHRAELSQLFYPLFVHMYLELVYNQHESEAKSFFEKF-H---------- 266

  Fly   169 PPPTKINGCSTTANESTFNIRFAKEAQDTGDTELDYFMRLVQTLSGYTRLEAAESDDTVAHFRSS 233
                                         ||.|. |:...::.||..|:.|..:.::|:..||:|
  Rat   267 -----------------------------GDQEC-YYQDDLRVLSSLTKKEHMKGNETMLDFRTS 301

  Fly   234 KYELHTTAVVVNRICAYLQRRGHVLIMNLLYTWLHVHIVENEQRAFSEDHLLGLTDDLEGEDGED 298
            |:.|..:......:..:||.:.:..|.|::...|::.|.:...|  |:..:..:...|.||...:
  Rat   302 KFVLRISRDSYQLLKRHLQEKQNNQIWNIVQEHLYIDIFDGMPR--SKQQIDAMVGSLAGEAKRE 364

  Fly   299 --------DVVSKPAVTL----------NTRGDIRPSKSLTEKSNRKRPAEEPNIMLETDIKQEV 345
                    .::.:|.:.:          |..|..:..|...:....|...::||...:..|...
  Rat   365 ANKSKVFFGLLKEPEIEVPLDDEDEEGENEEGKPKKKKPKKDSIGSKSKKQDPNAPPQNRIPLP- 428

  Fly   346 ETDESAELSKLQLNIDACLDTLKSATEQILKSQVELPR--FLRISERSRGLTSAHLDPSECHMLA 408
            |..:|.:|.|:.        .:|..|:::......||.  |.......:|||:..:......:..
  Rat   429 ELKDSDKLDKIM--------NMKETTKRVRLGPDCLPSICFYTFLNAYQGLTAVDVTDDSSLIAG 485

  Fly   409 GFDNSAVQLWQLNQSYCRGKSFYRRYPQKRCPWELNNCANQEEETDEDSSDEDVKCSEEERRERN 473
            ||.:|.|::|.:.                  |.:|.:.....:.:..|...:||.   |...:..
  Rat   486 GFADSTVRVWSVT------------------PKKLRSVKQASDLSLIDKESDDVL---ERIMDEK 529

  Fly   474 RARHCKYADNSYNEYGGFQLRGHTKGVTDVRFSAHYPLMYSVSKDATMRCWRAHNLHCAAIYRSH 538
            .|...|.            |.||:..|....||.....:.|.|:|.|:|.|......|...|:.|
  Rat   530 TASELKI------------LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGH 582

  Fly   539 NYPIWCLDESPVGQYVVTGSKDLSARLWSLEKEHALIIYAGHTQDVECVAFHPNGNYIATGSADH 603
            |||:|....||.|.|.|:|..|..||||:.:....|.|:|||..||.|..||||.||:||||||.
  Rat   583 NYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADR 647

  Fly   604 SVRLWCATSGKLMRVFADCRQAVTQLAFSPDGKMLAAAGEETKVRIFDLAAGAQLAELKDHSASI 668
            :||||...:|..:|:|...:..:..|.|||:|:.||....:.:|.::|:..|..:.|||.|:.::
  Rat   648 TVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTV 712

  Fly   669 SSLSWSTHNRHLATACSDGTLRLWD-IKKLSPMSDNSSAGSSSSATTNRVLTVNSSCQRLVDVFY 732
            .||.:|.....||:...|.|:|||| ||....:..:    ..::||.:..|..||  |.|:...|
  Rat   713 CSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETD----DFTTATGHINLPENS--QELLLGTY 771

  Fly   733 GTSKT 737
            .|..|
  Rat   772 MTKST 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wda	NP_651136.1	TAF5_NTD2	104..273	CDD:298747	32/168 (19%)
		WD40	324..>700	CDD:225201	113/378 (30%)
		WD40	491..700	CDD:238121	84/209 (40%)
		WD40 repeat	501..537	CDD:293791	10/35 (29%)
		WD40 repeat	542..578	CDD:293791	14/35 (40%)
		WD40 repeat	585..619	CDD:293791	19/33 (58%)
		WD40 repeat	626..662	CDD:293791	11/35 (31%)
Taf5	NP_001099835.1	TAF5_NTD2	209..341	CDD:176269	32/168 (19%)
		WD40	<457..738	CDD:225201	99/313 (32%)
		WD40	470..737	CDD:238121	96/299 (32%)
		WD40 repeat	471..539	CDD:293791	16/100 (16%)
		WD40 repeat	545..581	CDD:293791	10/35 (29%)
		WD40 repeat	586..622	CDD:293791	14/35 (40%)
		WD40 repeat	629..664	CDD:293791	19/34 (56%)
		WD40 repeat	670..706	CDD:293791	11/35 (31%)
		WD40 repeat	712..754	CDD:293791	13/45 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D230914at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19879
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020