DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wda and TAF5L

DIOPT Version :9

Sequence 1:	NP_651136.1	Gene:	wda / 42750	FlyBaseID:	FBgn0039067	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_055224.1	Gene:	TAF5L / 27097	HGNCID:	17304	Length:	589	Species:	Homo sapiens

Alignment Length:	719	Identity:	188/719 - (26%)
Similarity:	301/719 - (41%)	Gaps:	170/719 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KNDLLRCAVGLLLKQKNYVSNERFRRSDFLLLQNKQQFAVNKMLDTDLHGGNSFTFSNVQVITNN 99
            :.:.::.||...||::.||.::...:....|.|..::.|.|..:.::....|..:.:..|. ...
Human     5 RTEQIQMAVSCYLKRRQYVDSDGPLKQGLRLSQTAEEMAANLTVQSESGCANIVSAAPCQA-EPQ 68

  Fly   100 QHTVDQQFGRFSQFVEAQAEPLRLEMKRFYGPMLCHFYLDLLKAREPRGAVELLRKYAHLVAPVD 164
            |:.|  ||||...|:.........|:.....|:..:.:|:|:: ..|:..||            .
Human    69 QYEV--QFGRLRNFLTDSDSQHSHEVMPLLYPLFVYLHLNLVQ-NSPKSTVE------------S 118

  Fly   165 MYDAPPPTKINGCSTTANESTFNIRFAKEAQDTGDTELDYFMRLVQTLSGYTRLEAAESDDTVAH 229
            .|                 |.|:..|.:.|......|.....:.:|.:....:|.|
Human   119 FY-----------------SRFHGMFLQNASQKDVIEQLQTTQTIQDILSNFKLRA--------- 157

  Fly   230 FRSSKYELHTTAVVVNRICAYLQRRGHVLIMNLLYTWLHVHIVENEQRAFSEDHLLGLTDDLEGE 294
            |..:||.:.......|.:..|||...:..:..:|  .||:|:
Human   158 FLDNKYVVRLQEDSYNYLIRYLQSDNNTALCKVL--TLHIHL----------------------- 197

  Fly   295 DGEDDVVSKPAVTLNTRGDIRPSK-----------SLTEKSNRKRPAEEPNIMLETDIKQEVETD 348
                              |::|:|           |...::|...|.:.|:.:|:.
Human   198 ------------------DVQPAKRTDYQLYASGSSSRSENNGLEPPDMPSPILQN--------- 235

  Fly   349 ESAELSKLQLNIDACLDTLKSATEQILKSQVELPR--FLRISERSRGLTSAHLDPSECHMLAGFD 411
                        :|.|:.|:.:.:::......|..  |.......:.|.:|.:.|....:.||||
Human   236 ------------EAALEVLQESIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISPDSKLLAAGFD 288

  Fly   412 NSAVQLWQLNQSYCRGKSFYRRYPQKRCPWELN------NCANQEEETDEDSSDEDVKCSEEERR 470
            ||.::||.|     |.|..      |..|.:::      .|...|||.|||
Human   289 NSCIKLWSL-----RSKKL------KSEPHQVDVSRIHLACDILEEEDDED-------------- 328

  Fly   471 ERNRARHCKYADNSYNEYGGFQLRGHTKGVTDVRFSAHYPLMYSVSKDATMRCWRAHNLHCAAIY 535
                       ||:..|..  .||||...|...||.|....:.|.|:|.::|.|...:.....:|
Human   329 -----------DNAGTEMK--ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLY 380

  Fly   536 RSHNYPIWCLDESPVGQYVVTGSKDLSARLWSLEKEHALIIYAGHTQDVECVAFHPNGNYIATGS 600
            :.|.||:|.||.||...|..:||.|.:|||||.::.:.|.|||||..||:||.||||.||:||||
Human   381 QGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGS 445

  Fly   601 ADHSVRLWCATSGKLMRVFADCRQAVTQLAFSPDGKMLAAAGEETKVRIFDLAAGAQLAELKDHS 665
            .|.:||||.|..|..:|:|...|..|..|||||:||.||:|||:.:::::|||:|....||:.|:
Human   446 TDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHT 510

  Fly   666 ASISSLSWSTHNRHLATACSDGTLRLWDIKK--LSPMSDNSSA---GSSSSATTNRVLTVN-SSC 724
            .:|:||::|..:..:|:|..|.::|:|||:.  .|..:|.||:   |..:...:| ||:|. .:|
Human   511 DNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSN-VLSVQFMAC 574

  Fly   725 QRLV 728
            ..|:
Human   575 NLLL 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wda	NP_651136.1	TAF5_NTD2	104..273	CDD:298747	32/168 (19%)
		WD40	324..>700	CDD:225201	128/385 (33%)
		WD40	491..700	CDD:238121	93/210 (44%)
		WD40 repeat	501..537	CDD:293791	9/35 (26%)
		WD40 repeat	542..578	CDD:293791	16/35 (46%)
		WD40 repeat	585..619	CDD:293791	20/33 (61%)
		WD40 repeat	626..662	CDD:293791	18/35 (51%)
TAF5L	NP_055224.1	TAF5_NTD2	67..201	CDD:176269	35/217 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..230		3/18 (17%)
		WD 1	266..305		15/49 (31%)
		WD40 repeat	273..340	CDD:293791	26/104 (25%)
		WD40	276..581	CDD:238121	127/342 (37%)
		WD 2	340..379		11/38 (29%)
		WD40 repeat	346..382	CDD:293791	9/35 (26%)
		WD 3	382..421		18/38 (47%)
		WD40 repeat	387..423	CDD:293791	16/35 (46%)
		WD 4	424..463		23/38 (61%)
		WD40 repeat	430..465	CDD:293791	20/34 (59%)
		WD 5	466..505		18/38 (47%)
		WD40 repeat	471..507	CDD:293791	18/35 (51%)
		WD 6	508..547		13/38 (34%)
		WD40 repeat	513..539	CDD:293791	9/25 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160489
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2449
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D230914at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108737
Panther	1	1.100	-	-	O	PTHR19879
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5404
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.800