Protein Alignment wda and TAF5L

DIOPT Version :10

• Sequence 1: NP_651136.1
• Gene: wda / 42750
• FlyBaseID: FBgn0039067
• Length: 743
• Species: Drosophila melanogaster
• Sequence 2: NP_055224.1
• Gene: TAF5L / 27097
• HGNCID: 17304
• Length: 589
• Species: Homo sapiens
• Alignment Length: 717
• Identity: 192/717 - (26%)
• Similarity: 300/717 - (41%)
• Gaps: 166/717 - (23%)

  Fly    35 KNDLLRCAVGLLLKQKNYVSNERFRRSDFLLLQNKQQFAVNKMLDTDLHGGNSFTFSNVQVITNN 99
            :.:.::.||...||::.||.::...:....|.|..::.|.|..:.::....|..:.:..|. ...
Human     5 RTEQIQMAVSCYLKRRQYVDSDGPLKQGLRLSQTAEEMAANLTVQSESGCANIVSAAPCQA-EPQ 68

  Fly   100 QHTVDQQFGRFSQFVEAQAEPLRLEMKRFYGPMLCHFYLDLLKAREPRGAVELLRKYAHLVAPVD 164
            |:.|  ||||...|:.........|:.....|:..:.:|:|:: ..|:..||            .
Human    69 QYEV--QFGRLRNFLTDSDSQHSHEVMPLLYPLFVYLHLNLVQ-NSPKSTVE------------S 118

  Fly   165 MYDAPPPTKINGCSTTANESTFNIRFAKEAQDTGDTELDYFMRLVQTLSGYTRLEAAESDDTVAH 229
            .|                 |.|:..|.:.|......|.....:.:|.:....:|.|
Human   119 FY-----------------SRFHGMFLQNASQKDVIEQLQTTQTIQDILSNFKLRA--------- 157

  Fly   230 FRSSKYELHTTAVVVNRICAYLQRRGHVLIMNLLYTWLHVHIVENEQRAFSEDHLLGLTDDLEGE 294
            |..:||.:.......|.:..|||...:..:..:|  .||:|:
Human   158 FLDNKYVVRLQEDSYNYLIRYLQSDNNTALCKVL--TLHIHL----------------------- 197

  Fly   295 DGEDDVVSKPAVTLNTRGDIRPSK-----------SLTEKSNRKRPAEEPNIMLETDIKQEVETD 348
                              |::|:|           |...::|...|.:.|:.:|:.:
Human   198 ------------------DVQPAKRTDYQLYASGSSSRSENNGLEPPDMPSPILQNE-------- 236

  Fly   349 ESAELSKLQLNIDACLDTLKSATEQILKSQVELPRFLRISERSRGLTSAHLDPSECHMLAGFDNS 413
              |.|..||.:|....|...|.|...         |.......:.|.:|.:.|....:.||||||
Human   237 --AALEVLQESIKRVKDGPPSLTTIC---------FYAFYNTEQLLNTAEISPDSKLLAAGFDNS 290

  Fly   414 AVQLWQLNQSYCRGKSFYRRYPQKRCPWELN------NCANQEEETDEDSSDEDVKCSEEERRER 472
            .::||.|     |.|..      |..|.:::      .|...|||.|||
Human   291 CIKLWSL-----RSKKL------KSEPHQVDVSRIHLACDILEEEDDED---------------- 328

  Fly   473 NRARHCKYADNSYNEYGGFQLRGHTKGVTDVRFSAHYPLMYSVSKDATMRCWRAHNLHCAAIYRS 537
                     ||:..|..  .||||...|...||.|....:.|.|:|.::|.|...:.....:|:.
Human   329 ---------DNAGTEMK--ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQG 382

  Fly   538 HNYPIWCLDESPVGQYVVTGSKDLSARLWSLEKEHALIIYAGHTQDVECVAFHPNGNYIATGSAD 602
            |.||:|.||.||...|..:||.|.:|||||.::.:.|.|||||..||:||.||||.||:||||.|
Human   383 HAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTD 447

  Fly   603 HSVRLWCATSGKLMRVFADCRQAVTQLAFSPDGKMLAAAGEETKVRIFDLAAGAQLAELKDHSAS 667
            .:||||.|..|..:|:|...|..|..|||||:||.||:|||:.:::::|||:|....||:.|:.:
Human   448 KTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDN 512

  Fly   668 ISSLSWSTHNRHLATACSDGTLRLWDIKK--LSPMSDNSSA---GSSSSATTNRVLTVN-SSCQR 726
            |:||::|..:..:|:|..|.::|:|||:.  .|..:|.||:   |..:...:| ||:|. .:|..
Human   513 ITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSN-VLSVQFMACNL 576

  Fly   727 LV 728
            |:
Human   577 LL 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wda	NP_651136.1	TAF5_NTD2	104..273	CDD:471824	32/168 (19%)
		WD40	<493..695	CDD:441893	91/201 (45%)
		WD40 repeat	501..537	CDD:293791	9/35 (26%)
		WD40 repeat	542..578	CDD:293791	16/35 (46%)
		WD40 repeat	585..619	CDD:293791	20/33 (61%)
		WD40 repeat	626..662	CDD:293791	18/35 (51%)
TAF5L	NP_055224.1	TAF5_NTD2	67..201	CDD:176269	35/217 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..230		3/18 (17%)
		WD 1	266..305		15/49 (31%)
		WD40	<272..541	CDD:441893	117/306 (38%)
		WD40 repeat	273..340	CDD:293791	26/104 (25%)
		WD 2	340..379		11/38 (29%)
		WD40 repeat	346..382	CDD:293791	9/35 (26%)
		WD 3	382..421		18/38 (47%)
		WD40 repeat	387..423	CDD:293791	16/35 (46%)
		WD 4	424..463		23/38 (61%)
		WD40 repeat	430..465	CDD:293791	20/34 (59%)
		WD 5	466..505		18/38 (47%)
		WD40 repeat	471..507	CDD:293791	18/35 (51%)
		WD 6	508..547		13/38 (34%)
		WD40 repeat	513..539	CDD:293791	9/25 (36%)