DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wda and taf73

DIOPT Version :9

Sequence 1:	NP_651136.1	Gene:	wda / 42750	FlyBaseID:	FBgn0039067	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_596254.1	Gene:	taf73 / 2539882	PomBaseID:	SPBC15D4.14	Length:	642	Species:	Schizosaccharomyces pombe

Alignment Length:	782	Identity:	173/782 - (22%)
Similarity:	301/782 - (38%)	Gaps:	211/782 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 KSSASSKKTSSKNDLLRCAVGLLLKQKNYVSNE---RFRRSDFLLLQNKQQFAVNKMLDTDLHGG 85
            :||.||..::|  ||.:..:..|.| |.|...|   |...|....:..:||         |.|.|
pombe     3 QSSYSSGNSTS--DLNKIVLDYLFK-KGYSRTEAMLRLEISSVGAIPEEQQ---------DWHIG 55

  Fly    86 NSFTFSNVQVITNNQHTVDQQFGRFSQFVEAQAEPLRLEMKRFYGPMLCHFYLDLLKAREPRGAV 150
            .|.|:..|.::..:             :::...:..:.::::...|:..|.|||||:..:|..|:
pombe    56 ASETYVQVYILLRD-------------WIDGTLDLYKPKLQKVLYPIFVHSYLDLLQKNDPEMAI 107

  Fly   151 ELLRKY--AHLVAPVDMYDAPPPTKINGCSTTANESTFNIRFAKEAQDTGDTELDYFMRLVQTLS 213
            .....:  .|.|             ::|         ::||...:.:...|.|
pombe   108 YFFESFRIEHEV-------------LHG---------YDIRALAQLKIASDVE------------ 138

  Fly   214 GYTRLEAAESDDTVAHFRSSKYELHTTAVVVNRICAYL---QRRGHVLIMNLLYTWLHVHI---- 271
               .:|.|:.      :|.:||.::.|....:.:..:|   :..|..:|:.||..::.:.|
pombe   139 ---EIEIAQL------YRKNKYRINFTRSTFDLLVQFLFENEVNGSGIIIRLLNQYIDIKITMPQ 194

  Fly   272 -----------------VENEQ----------------------------RAFSEDHLLGLTDDL 291
                             .:|||                            |..||:.:..|.:.|
pombe   195 VEGKEDPNVQAVYEMDEAKNEQTIISEQEGIPGHSEQLLDYNKQSIQLGLRPLSEEVVTTLKNLL 259

  Fly   292 EGED----GEDDVVSKPAVTLNTRGDIRPSKSLTEKSNRKRPAEEPNIMLETDIKQEVETDESAE 352
            |.:|    |.::.::|         .:.|:|:|.|..     .|:.|::.|:.:  |..:|....
pombe   260 EVKDKDVEGRNEALNK---------ILHPAKNLVELL-----TEKENLINESTL--ESPSDPPLP 308

  Fly   353 LSKLQLNIDACLDTLKSATEQIL--KSQVELPRFLRISERSRGLTSAHLDPSECHMLA-GFDNSA 414
            .:|:: :||..:..|:|....::  |:..:...|:.....:....:......:..|.| |..:|:
pombe   309 PTKMK-DIDYFVSLLESEQNSLILGKNATDPSVFMYTMHNTLSAVNCAAFSDDASMFALGCADSS 372

  Fly   415 VQLWQLNQSYCRGKSFYRRYPQKRCPWELNNCANQEEETDEDSSDEDVKCSEEERRERNRARHCK 479
            :.|:                                  :..::..:.:..|:.|..:::
pombe   373 IHLY----------------------------------SSTNNGPQPLVGSQNEPLQKS------ 397

  Fly   480 YADNSYNEYGGFQLRGHTKGVTDVRFSAHYPLMYSVSKDATMRCWRAHNLHCAAIYRSHNYPIWC 544
                        .|.|||:.|..|..|.....:.|.|:|...|.|..........|..||.|||.
pombe   398 ------------SLIGHTRPVFGVSISPQKEFILSCSEDGFTRLWSKDTKSTIVKYAGHNAPIWD 450

  Fly   545 LDESPVGQYVVTGSKDLSARLWSLEKEHALIIYAGHTQDVECVAFHPNGNYIATGSADHSVRLWC 609
            :..||.|.|..|.|.|.:||||.:|....|.::.||..||:||:||||..|:||||:||:.|:|.
pombe   451 VQFSPFGYYFATASHDQTARLWDVEHAAPLRVFVGHQNDVDCVSFHPNAAYLATGSSDHTTRMWD 515

  Fly   610 ATSGKLMRVFADCRQAVTQLAFSPDGKMLAAAGEETKVRIFDLAAGAQLAELKDHSASISSLSWS 674
            ..:|..:|||......|:.|..|.||..||:|.|...::::||.:..|......||:.:.|||:|
pombe   516 VRTGGTVRVFNAHHSPVSALCMSADGLSLASADESGIIKVWDLRSSNQHVSFVKHSSIVYSLSFS 580

  Fly   675 THNRHLATACSDGTLRLWDIKKLSPMSDNSSAGSSSSATTNRVLTVNSSCQRLVDVFYGTSKTLY 739
            ..|:.|.:..:|..:..||:...:.:||    |..|....| ..|.|:..|.|     ..::..|
pombe   581 YDNKILVSGGADTDVNFWDLTYRNNLSD----GEQSPLLFN-FKTKNTIIQNL-----SFTRRNY 635

  Fly   740 CI 741
            |:
pombe   636 CL 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wda	NP_651136.1	TAF5_NTD2	104..273	CDD:298747	28/194 (14%)
		WD40	324..>700	CDD:225201	96/378 (25%)
		WD40	491..700	CDD:238121	77/208 (37%)
		WD40 repeat	501..537	CDD:293791	8/35 (23%)
		WD40 repeat	542..578	CDD:293791	15/35 (43%)
		WD40 repeat	585..619	CDD:293791	17/33 (52%)
		WD40 repeat	626..662	CDD:293791	12/35 (34%)
taf73	NP_596254.1	LisH	14..38	CDD:128913	8/24 (33%)
		TFIID_NTD2	58..186	CDD:309580	29/183 (16%)
		WD40	350..600	CDD:238121	83/301 (28%)
		WD40 repeat	354..401	CDD:293791	8/98 (8%)
		WD40 repeat	407..443	CDD:293791	8/35 (23%)
		WD40 repeat	448..484	CDD:293791	15/35 (43%)
		WD40 repeat	491..526	CDD:293791	18/34 (53%)
		WD40 repeat	532..568	CDD:293791	12/35 (34%)
		WD40 repeat	574..600	CDD:293791	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19879
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.970