DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wda and WDR7

DIOPT Version :9

Sequence 1:	NP_651136.1	Gene:	wda / 42750	FlyBaseID:	FBgn0039067	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001369416.1	Gene:	WDR7 / 23335	HGNCID:	13490	Length:	1490	Species:	Homo sapiens

Alignment Length:	709	Identity:	125/709 - (17%)
Similarity:	227/709 - (32%)	Gaps:	244/709 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 DLHGGNSFTFSNVQVITNNQHTVDQQFGRFSQFVEAQAEPLRLEMKRFYGPMLCH-FYLDLLKAR 144
            |:..|....|:.:..    .|| ..||.:||  |..|.|          |.:||| .|.::|..
Human    95 DVSDGRCIEFTKLAC----THT-GIQFYQFS--VGNQRE----------GRLLCHGHYPEILVV- 141

  Fly   145 EPRGAVELLRKYAHLVAPVDMYDAPPPTKINGCSTTANESTFNIRFAKEAQDTGDTELDYFMRLV 209
               .|..|...|: ||:.:.      |..|:..|.        ||..:..:||         .:.
Human   142 ---DATSLEVLYS-LVSKIS------PDWISSMSI--------IRSHRTQEDT---------VVA 179

  Fly   210 QTLSGYTRL-----EAAESDDTVAHFRSSKYELHTTAVVVNRICAYLQRRGHVLIMNLLY----- 264
            .:::|..::     |.::..||...|......::.........||:.||  .:|::...|
Human   180 LSVTGILKVWIVTSEISDMQDTEPIFEEESKPIYCQNCQSISFCAFTQR--SLLVVCSKYWRVFD 242

  Fly   265 ----------------TWLHVHIVENEQRAFSEDHLLGLTDDLEGEDGEDDVVSKPAVTL----N 309
                            ||.....|       |.|.::..|     |:|:..:...||..|    :
Human   243 AGDYSLLCSGPSENGQTWTGGDFV-------SSDKVIIWT-----ENGQSYIYKLPASCLPASDS 295

  Fly   310 TRGDI-----------------RPSKSLT-----------------------EKSNRKRPAEEPN 334
            .|.|:                 |..|.|.                       :.|.|.      |
Human   296 FRSDVGKAVENLIPPVQHILLDRKDKELLICPPVTRFFYGCREYFHKLLIQGDSSGRL------N 354

  Fly   335 IMLETDIKQEVETDESAELSKLQLNIDACLDTLKSATEQILKSQVELPRFLRISERSRGLTSAHL 399
            |...:|...:..::|...:: ..:::....|.|......|:.....:|.    |.....:|::..
Human   355 IWNISDTADKQGSEEGLAMT-TSISLQEAFDKLNPCPAGIIDQLSVIPN----SNEPLKVTASVY 414

  Fly   400 DPSECHMLAGFDNSAVQLWQLNQS----YCRGKSFYRR-YPQKRCPWELNNCANQEEETDEDSSD 459
            .|:...::.|.::.::.:....|:    ..:|:...|| :|..|
Human   415 IPAHGRLVCGREDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHR--------------------- 458

  Fly   460 EDVKCSEEERRERNRARHCKYADNSYNEYGGFQLRGHTKGVTDVRF----SAHYPLMYSVS--KD 518
                                            .||||...||.:.:    ||.|...|.:|  .|
Human   459 --------------------------------TLRGHRNKVTCLLYPHQVSARYDQRYLISGGVD 491

  Fly   519 ATMRCWRAHNLHCAAIYRSHNYPIWCLDESPVGQYVV--------------TGSKDLSARLWSLE 569
            .::..|        .|:......|:|:....:.|.:|              :.:.|.|..|.||.
Human   492 FSVIIW--------DIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLR 548

  Fly   570 KEHALIIYAGHTQDVECVAFHPNGNYIATGSADHSVRLWCATSGKLMRVFADCRQAVTQLAFSPD 634
            ::..:::.:.|...::.:.:.|:.:|:..|.:|.||.:|...:|.|.|    |...:|.:
Human   549 EKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDR----CVMGITAV----- 604

  Fly   635 GKMLAAAGEETKVRIFDLAAGAQLAELKDHSASISSLSWSTHNR-------HLATACSD 686
             ::|.|..|.....:..|:..|...:......|:::|....|::       .||:..||
Human   605 -EILNACDEAVPAAVDSLSHPAVNLKQAMTRRSLAALKNMAHHKLQTLATNLLASEASD 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wda	NP_651136.1	TAF5_NTD2	104..273	CDD:298747	38/195 (19%)
		WD40	324..>700	CDD:225201	68/395 (17%)
		WD40	491..700	CDD:238121	48/223 (22%)
		WD40 repeat	501..537	CDD:293791	9/41 (22%)
		WD40 repeat	542..578	CDD:293791	9/49 (18%)
		WD40 repeat	585..619	CDD:293791	10/33 (30%)
		WD40 repeat	626..662	CDD:293791	6/35 (17%)
WDR7	NP_001369416.1	WD 1	17..56
		WD40	<19..102	CDD:421866	2/6 (33%)
		WD40 repeat	22..62	CDD:293791
		WD 2	62..104		2/8 (25%)
		WD40 repeat	68..109	CDD:293791	3/13 (23%)
		WD40 repeat	114..153	CDD:293791	16/55 (29%)
		WD 3	156..199		9/65 (14%)
		WD40 repeat	162..208	CDD:293791	10/62 (16%)
		WD 4	324..366		5/47 (11%)
		WD 5	404..443		4/38 (11%)
		WD40	408..>598	CDD:421866	43/254 (17%)
		WD40 repeat	409..461	CDD:293791	9/104 (9%)
		WD 6	462..507		12/52 (23%)
		WD40 repeat	516..558	CDD:293791	7/41 (17%)
		WD 7	558..597		11/42 (26%)
		WD40 repeat	563..589	CDD:293791	7/25 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	761..783
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..945
		WD 8	1351..1390
		WD40	<1357..1426	CDD:421866
		WD40 repeat	1357..1391	CDD:293791
		WD 9	1392..1432
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900