DRSC/TRiP Functional Genomics Resources

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Protein Alignment wda and Apaf1

DIOPT Version :10

Sequence 1:NP_651136.1 Gene:wda / 42750 FlyBaseID:FBgn0039067 Length:743 Species:Drosophila melanogaster
Sequence 2:NP_033814.2 Gene:Apaf1 / 11783 MGIID:1306796 Length:1249 Species:Mus musculus


Alignment Length:894 Identity:154/894 - (17%)
Similarity:257/894 - (28%) Gaps:378/894 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 YSNSNNNKSSASSKKTSS-----KNDLLRCAVGLLLKQ-KNYVSNERFRRSDFLL---------- 65
            |.....||.....:|:||     .::.:..:|.:|.:. |:|.::....:.|..:          
Mouse   341 YLRQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCVLWD 405

  Fly    66 LQNK------QQFAVNKMLDTDLHGGNSFTFSNVQVITNNQHTVDQQFGRFSQFVEAQAEPLRLE 124
            |:.:      |:| |||.|......|.||.:          :..|.|....::...:|.:.|..:
Mouse   406 LETEEVEDILQEF-VNKSLLFCNRNGKSFCY----------YLHDLQVDFLTEKNRSQLQDLHRK 459

  Fly   125 M----KRFYGP----------------------------MLC--HFYLDLLKAR-EPRGAVELLR 154
            |    :|:|.|                            .||  .|.||.:||: |..|...|:.
Mouse   460 MVTQFQRYYQPHTLSPDQEDCMYWYNFLAYHMASANMHKELCALMFSLDWIKAKTELVGPAHLIH 524

  Fly   155 K---YAHLVAPVDMYDAPPPTKINGCSTTANESTFNIRFAKEAQDTGDTELDYFMRL----VQTL 212
            :   |.|::...|            |:...|...|   .:......|.......::|    .:|.
Mouse   525 EFVAYRHILDEKD------------CAVCENFQEF---LSLNGHLLGRQPFPNIVQLGLCEPETS 574

  Fly   213 SGY--TRLEAAESDDTVAHFRSSKYELHTTAVVVNRICAYLQRRGHVLIMNLLYTWLHVHIVENE 275
            ..|  .:|:|.:..||                  .|:  ||:             |::...::|.
Mouse   575 EVYRQAKLQAKQEGDT------------------GRL--YLE-------------WINKKTIKNL 606

  Fly   276 QRAFSEDHLLGLTDDLEGEDGEDDVVSKPAVTLNTRGDIRPSKSLTEKSNRKRPAEEPNIMLETD 340
            .|.....|...:......:||:                 |.:....:|:.:...||....:|  |
Mouse   607 SRLVVRPHTDAVYHACFSQDGQ-----------------RIASCGADKTLQVFKAETGEKLL--D 652

  Fly   341 IKQEVETDESAELSKLQLNIDACLDTLK-----SATEQILKSQVELPRFLRISERSRGLTSAHLD 400
            ||...:.......|.....|..|....|     |||.:::.:         ..|.|..:...|..
Mouse   653 IKAHEDEVLCCAFSSDDSYIATCSADKKVKIWDSATGKLVHT---------YDEHSEQVNCCHFT 708

  Fly   401 PSECHML--AGFDNSAVQLWQLNQSYCRGKSFYRRYPQKRCPWELNNCANQEEETDEDSSDEDVK 463
            ....|:|  .|.::..::||.|||..||...|                                 
Mouse   709 NKSNHLLLATGSNDFFLKLWDLNQKECRNTMF--------------------------------- 740

  Fly   464 CSEEERRERNRARHCKYADNSYNEYGGFQLRGHTKGVTDVRFSAHYPLMYSVSKDATMRCW--RA 526
                                           |||..|...|||....|:.|.|.|.|:|.|  |:
Mouse   741 -------------------------------GHTNSVNHCRFSPDDELLASCSADGTLRLWDVRS 774

  Fly   527 HN-------------------------------------------------LH----CAAIYRSH 538
            .|                                                 :|    .|.|:..|
Mouse   775 ANERKSINVKRFFLSSEDPPEDVEVIVKCCSWSADGDKIIVAAKNKVLLFDIHTSGLLAEIHTGH 839

  Fly   539 NYPIWCLDESPVGQYVVTGSKDLSARLWSLEKEHALIIYAGHTQDVECVAFHPNGNYIATGSADH 603
            :..|...|.||.....|.........||:::....:....||...|..|.|.|:|:...|.|.|.
Mouse   840 HSTIQYCDFSPYDHLAVIALSQYCVELWNIDSRLKVADCRGHLSWVHGVMFSPDGSSFLTASDDQ 904

  Fly   604 SVRLW-----CATSGKLM----------------------------------------------- 616
            ::|:|     |..|..::                                               
Mouse   905 TIRVWETKKVCKNSAIVLKQEIDVVFQENETMVLAVDNIRGLQLIAGKTGQIDYLPEAQVSCCCL 969

  Fly   617 ------------------------RVFAD---CRQAVTQLAFSPDGKMLAAAGEETKVRIFDLAA 654
                                    |||:.   .::||..:.|:.|||.|.::.|::.:::::...
Mouse   970 SPHLEYVAFGDEDGAIKIIELPNNRVFSSGVGHKKAVRHIQFTADGKTLISSSEDSVIQVWNWQT 1034

  Fly   655 GAQLAELKDHSASISS---------LSWSTHNRHLATACSDGTLRLWDI 694
            | ....|:.|..::..         ||||          .|||:::|::
Mouse  1035 G-DYVFLQAHQETVKDFRLLQDSRLLSWS----------FDGTVKVWNV 1072

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wdaNP_651136.1 TAF5_NTD2 104..273 CDD:471824 36/212 (17%)
WD40 <493..695 CDD:441893 63/345 (18%)
WD40 repeat 501..537 CDD:293791 15/90 (17%)
WD40 repeat 542..578 CDD:293791 7/35 (20%)
WD40 repeat 585..619 CDD:293791 12/109 (11%)
WD40 repeat 626..662 CDD:293791 8/35 (23%)
Apaf1NP_033814.2 CARD_APAF1 7..92 CDD:260034
NB-ARC 129..374 CDD:395745 7/32 (22%)
APAF1_C 453..587 CDD:465560 27/148 (18%)
WD 1-1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 613..652 8/57 (14%)
WD40 623..1207 CDD:441893 94/553 (17%)
WD40 repeat 623..655 CDD:293791 9/50 (18%)
WD 1-2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 655..694 7/38 (18%)
WD40 repeat 661..697 CDD:293791 7/44 (16%)
WD 1-3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 697..738 13/40 (33%)
WD40 repeat 702..740 CDD:293791 11/37 (30%)
WD 1-4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 741..780 16/38 (42%)
WD40 repeat 747..789 CDD:293791 12/41 (29%)
eIF2A <796..931 CDD:462552 25/134 (19%)
WD 1-5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 796..837 3/40 (8%)
WD40 repeat 801..837 CDD:293791 3/35 (9%)
WD 1-6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 838..877 8/38 (21%)
WD40 repeat 843..882 CDD:293791 8/38 (21%)
WD 1-7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 880..910 11/29 (38%)
WD40 repeat 885..909 CDD:293791 9/23 (39%)
Interpropeller linker 910..921 2/10 (20%)
WD 2-1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 922..958 0/35 (0%)
WD 2-2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 959..998 3/38 (8%)
WD40 repeat 964..999 CDD:293791 3/34 (9%)
WD 2-3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 1001..1040 9/39 (23%)
WD40 repeat 1006..1030 CDD:293791 7/23 (30%)
WD 2-4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 1042..1080 9/41 (22%)
WD40 repeat 1048..1082 CDD:293791 8/35 (23%)
WD 2-5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 1083..1122
WD40 repeat 1089..1124 CDD:293791
WD 2-6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 1125..1164
WD40 repeat 1130..1174 CDD:293791
WD 2-7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 1176..1213
WD40 repeat 1181..1203 CDD:293791
WD 2-8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 1214..1249
Blue background indicates that the domain is not in the aligned region.

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