DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wda and Apaf1

DIOPT Version :9

Sequence 1:NP_651136.1 Gene:wda / 42750 FlyBaseID:FBgn0039067 Length:743 Species:Drosophila melanogaster
Sequence 2:NP_001036023.1 Gene:Apaf1 / 11783 MGIID:1306796 Length:1249 Species:Mus musculus


Alignment Length:894 Identity:154/894 - (17%)
Similarity:257/894 - (28%) Gaps:378/894 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 YSNSNNNKSSASSKKTSS-----KNDLLRCAVGLLLKQ-KNYVSNERFRRSDFLL---------- 65
            |.....||.....:|:||     .::.:..:|.:|.:. |:|.::....:.|..:          
Mouse   341 YLRQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCVLWD 405

  Fly    66 LQNK------QQFAVNKMLDTDLHGGNSFTFSNVQVITNNQHTVDQQFGRFSQFVEAQAEPLRLE 124
            |:.:      |:| |||.|......|.||.:          :..|.|....::...:|.:.|..:
Mouse   406 LETEEVEDILQEF-VNKSLLFCNRNGKSFCY----------YLHDLQVDFLTEKNRSQLQDLHRK 459

  Fly   125 M----KRFYGP----------------------------MLC--HFYLDLLKAR-EPRGAVELLR 154
            |    :|:|.|                            .||  .|.||.:||: |..|...|:.
Mouse   460 MVTQFQRYYQPHTLSPDQEDCMYWYNFLAYHMASANMHKELCALMFSLDWIKAKTELVGPAHLIH 524

  Fly   155 K---YAHLVAPVDMYDAPPPTKINGCSTTANESTFNIRFAKEAQDTGDTELDYFMRL----VQTL 212
            :   |.|::...|            |:...|...|   .:......|.......::|    .:|.
Mouse   525 EFVAYRHILDEKD------------CAVCENFQEF---LSLNGHLLGRQPFPNIVQLGLCEPETS 574

  Fly   213 SGY--TRLEAAESDDTVAHFRSSKYELHTTAVVVNRICAYLQRRGHVLIMNLLYTWLHVHIVENE 275
            ..|  .:|:|.:..||                  .|:  ||:             |::...::|.
Mouse   575 EVYRQAKLQAKQEGDT------------------GRL--YLE-------------WINKKTIKNL 606

  Fly   276 QRAFSEDHLLGLTDDLEGEDGEDDVVSKPAVTLNTRGDIRPSKSLTEKSNRKRPAEEPNIMLETD 340
            .|.....|...:......:||:                 |.:....:|:.:...||....:|  |
Mouse   607 SRLVVRPHTDAVYHACFSQDGQ-----------------RIASCGADKTLQVFKAETGEKLL--D 652

  Fly   341 IKQEVETDESAELSKLQLNIDACLDTLK-----SATEQILKSQVELPRFLRISERSRGLTSAHLD 400
            ||...:.......|.....|..|....|     |||.:::.:         ..|.|..:...|..
Mouse   653 IKAHEDEVLCCAFSSDDSYIATCSADKKVKIWDSATGKLVHT---------YDEHSEQVNCCHFT 708

  Fly   401 PSECHML--AGFDNSAVQLWQLNQSYCRGKSFYRRYPQKRCPWELNNCANQEEETDEDSSDEDVK 463
            ....|:|  .|.::..::||.|||..||...|                                 
Mouse   709 NKSNHLLLATGSNDFFLKLWDLNQKECRNTMF--------------------------------- 740

  Fly   464 CSEEERRERNRARHCKYADNSYNEYGGFQLRGHTKGVTDVRFSAHYPLMYSVSKDATMRCW--RA 526
                                           |||..|...|||....|:.|.|.|.|:|.|  |:
Mouse   741 -------------------------------GHTNSVNHCRFSPDDELLASCSADGTLRLWDVRS 774

  Fly   527 HN-------------------------------------------------LH----CAAIYRSH 538
            .|                                                 :|    .|.|:..|
Mouse   775 ANERKSINVKRFFLSSEDPPEDVEVIVKCCSWSADGDKIIVAAKNKVLLFDIHTSGLLAEIHTGH 839

  Fly   539 NYPIWCLDESPVGQYVVTGSKDLSARLWSLEKEHALIIYAGHTQDVECVAFHPNGNYIATGSADH 603
            :..|...|.||.....|.........||:::....:....||...|..|.|.|:|:...|.|.|.
Mouse   840 HSTIQYCDFSPYDHLAVIALSQYCVELWNIDSRLKVADCRGHLSWVHGVMFSPDGSSFLTASDDQ 904

  Fly   604 SVRLW-----CATSGKLM----------------------------------------------- 616
            ::|:|     |..|..::                                               
Mouse   905 TIRVWETKKVCKNSAIVLKQEIDVVFQENETMVLAVDNIRGLQLIAGKTGQIDYLPEAQVSCCCL 969

  Fly   617 ------------------------RVFAD---CRQAVTQLAFSPDGKMLAAAGEETKVRIFDLAA 654
                                    |||:.   .::||..:.|:.|||.|.::.|::.:::::...
Mouse   970 SPHLEYVAFGDEDGAIKIIELPNNRVFSSGVGHKKAVRHIQFTADGKTLISSSEDSVIQVWNWQT 1034

  Fly   655 GAQLAELKDHSASISS---------LSWSTHNRHLATACSDGTLRLWDI 694
            | ....|:.|..::..         ||||          .|||:::|::
Mouse  1035 G-DYVFLQAHQETVKDFRLLQDSRLLSWS----------FDGTVKVWNV 1072

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wdaNP_651136.1 TAF5_NTD2 104..273 CDD:298747 36/212 (17%)
WD40 324..>700 CDD:225201 90/521 (17%)
WD40 491..700 CDD:238121 63/347 (18%)
WD40 repeat 501..537 CDD:293791 15/90 (17%)
WD40 repeat 542..578 CDD:293791 7/35 (20%)
WD40 repeat 585..619 CDD:293791 12/109 (11%)
WD40 repeat 626..662 CDD:293791 8/35 (23%)
Apaf1NP_001036023.1 CARD_APAF1 7..92 CDD:260034
NB-ARC 129..374 CDD:395745 7/32 (22%)
APAF1_C 453..587 CDD:407760 27/148 (18%)
WD40 607..910 CDD:238121 71/394 (18%)
WD 1-1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 613..652 8/57 (14%)
WD40 repeat 623..655 CDD:293791 9/50 (18%)
WD 1-2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 655..694 7/38 (18%)
WD40 repeat 661..697 CDD:293791 7/44 (16%)
WD 1-3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 697..738 13/40 (33%)
WD40 repeat 702..740 CDD:293791 11/37 (30%)
WD 1-4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 741..780 16/38 (42%)
WD40 repeat 747..789 CDD:293791 12/41 (29%)
WD 1-5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 796..837 3/40 (8%)
WD40 repeat 801..837 CDD:293791 3/35 (9%)
WD 1-6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 838..877 8/38 (21%)
WD40 repeat 843..882 CDD:293791 8/38 (21%)
WD 1-7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 880..910 11/29 (38%)
WD40 repeat 885..909 CDD:293791 9/23 (39%)
Interpropeller linker 910..921 2/10 (20%)
WD 2-1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 922..958 0/35 (0%)
WD 2-2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 959..998 3/38 (8%)
WD40 961..1235 CDD:238121 22/123 (18%)
WD40 repeat 964..999 CDD:293791 3/34 (9%)
WD 2-3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 1001..1040 9/39 (23%)
WD40 repeat 1006..1030 CDD:293791 7/23 (30%)
WD 2-4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 1042..1080 9/41 (22%)
WD40 repeat 1048..1082 CDD:293791 8/35 (23%)
WD 2-5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 1083..1122
WD40 repeat 1089..1124 CDD:293791
WD 2-6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 1125..1164
WD40 repeat 1130..1174 CDD:293791
WD 2-7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 1176..1213
WD40 repeat 1181..1203 CDD:293791
WD 2-8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:21827944 1214..1249
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4155
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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