DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wda and Wdr7

DIOPT Version :9

Sequence 1:	NP_651136.1	Gene:	wda / 42750	FlyBaseID:	FBgn0039067	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001014981.1	Gene:	Wdr7 / 104082	MGIID:	1860197	Length:	1489	Species:	Mus musculus

Alignment Length:	703	Identity:	127/703 - (18%)
Similarity:	232/703 - (33%)	Gaps:	232/703 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 DLHGGNSFTFSNVQVITNNQHTVDQQFGRFSQFVEAQAEPLRLEMKRFYGPMLCH-FYLDLLKAR 144
            |::.|....|:.:..    .|| ..||.:||  |..|.|          |.:||| .|.::|..
Mouse    95 DVNDGRCIEFTKLAC----THT-GIQFYQFS--VGNQQE----------GRLLCHGHYPEILVV- 141

  Fly   145 EPRGAVELLRKYAHLVAPVDMYDAPPPTKINGCSTTANESTFNIRFAKEAQDTGDTELDYFMRLV 209
               .|..|...|: ||:.:.      |..|:..|.        ||..:..:||         .:.
Mouse   142 ---DATSLEVLYS-LVSKIS------PDWISSMSI--------IRSQRTQEDT---------VVA 179

  Fly   210 QTLSGYTRL-----EAAESDDTVAHFRSSKYELHTTAVVVNRICAYLQRRGHVLIMNLLY----- 264
            .:::|..::     |.:...||...|......::.........||:.||  .:|::...|
Mouse   180 LSVTGILKVWIVTSEMSGMQDTEPIFEEESKPIYCQNCQSISFCAFTQR--SLLVVCSKYWRVFD 242

  Fly   265 ----------------TWLHVHIVENEQRAFSEDHLLGLTDDLEGEDGEDDVVSKPAVTL----N 309
                            ||.....|       |.|.::..|     |:|:..:...||..|    :
Mouse   243 AGDYSLLCSGPSENGQTWTGGDFV-------SADKVIIWT-----ENGQSYIYKLPASCLPASDS 295

  Fly   310 TRGDIRPS---------KSLTEKSNRKRPAEEP-------------------------NIMLETD 340
            .|.|:..:         .||.::.:::.....|                         ||....|
Mouse   296 FRSDVGKAVENLIPPVQHSLLDQKDKELVICPPVTRFFYGCKEYLHKLLIQGDSSGRLNIWNIAD 360

  Fly   341 IKQEVETDESAELSKLQLNIDACLDTLKSATEQILKSQVELPRFLRISERSRGLTSAHLDPSECH 405
            |.::.|.||..:::.. :::....|.||.....|:.....:|.    |.....:|::...|:...
Mouse   361 IAEKQEADEGLKMTTC-ISLQEAFDKLKPCPAGIIDQLSVIPN----SNEPLKVTASVYIPAHGR 420

  Fly   406 MLAGFDNSAVQLWQLNQS----YCRGKSFYRR-YPQKRCPWELNNCANQEEETDEDSSDEDVKCS 465
            ::.|.::.::.:....|:    ..:|:...|| :|..|
Mouse   421 LVCGREDGSIIIVPATQTAIVQLLQGEHMLRRGWPPHR--------------------------- 458

  Fly   466 EEERRERNRARHCKYADNSYNEYGGFQLRGHTKGVTDVRF----SAHYPLMYSVS--KDATMRCW 524
                                      .||||...||.:.:    ||.|...|.:|  .|.::..|
Mouse   459 --------------------------TLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIW 497

  Fly   525 RAHNLHCAAIYRSHNYPIWCLDESPVGQYVV--------------TGSKDLSARLWSLEKEHALI 575
                    .|:......|:|:....:.|.:|              :.:.|.|..|.||.::..::
Mouse   498 --------DIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIM 554

  Fly   576 IYAGHTQDVECVAFHPNGNYIATGSADHSVRLWCATSGKLMRVFADCRQAVTQLAFSPDGKMLAA 640
            :.:.|...::.:.:.|:.:|:..|..|.||.:|...:|.|.|    |...:|.:      ::|.|
Mouse   555 LASRHLFPIQVIKWRPSDDYLVVGCTDGSVYVWQMDTGALDR----CAMGITAV------EILNA 609

  Fly   641 AGEETKVRIFDLAAGAQLAELKDHSASISSLSWSTHNR-------HLATACSD 686
            ..|.....:..|:..|...:......|:::|....|::       .||:..||
Mouse   610 CDEAVPAAVDSLSHPAVNLKQAMTRRSLAALKNMAHHKLQTLATNLLASEASD 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wda	NP_651136.1	TAF5_NTD2	104..273	CDD:298747	38/195 (19%)
		WD40	324..>700	CDD:225201	71/420 (17%)
		WD40	491..700	CDD:238121	48/223 (22%)
		WD40 repeat	501..537	CDD:293791	9/41 (22%)
		WD40 repeat	542..578	CDD:293791	9/49 (18%)
		WD40 repeat	585..619	CDD:293791	10/33 (30%)
		WD40 repeat	626..662	CDD:293791	6/35 (17%)
Wdr7	NP_001014981.1	WD40	16..274	CDD:295369	46/232 (20%)
		WD 1	17..56
		WD40	<19..199	CDD:225201	32/148 (22%)
		WD40 repeat	22..62	CDD:293791
		WD 2	62..104		2/8 (25%)
		WD40 repeat	68..109	CDD:293791	3/13 (23%)
		WD40 repeat	114..153	CDD:293791	16/55 (29%)
		WD 3	156..199		9/65 (14%)
		WD40 repeat	162..205	CDD:293791	9/59 (15%)
		WD 4	324..366		5/41 (12%)
		WD40	341..>592	CDD:225201	53/316 (17%)
		WD 5	404..443		4/38 (11%)
		WD40	408..>592	CDD:295369	40/244 (16%)
		WD 6	462..507		12/52 (23%)
		WD40 repeat	516..558	CDD:293791	7/41 (17%)
		WD 7	558..597		11/42 (26%)
		WD40 repeat	563..589	CDD:293791	7/25 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	754..783
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..947
		WD 8	1350..1389
		WD40 repeat	1355..1391	CDD:293791
		WD40	<1356..1425	CDD:295369
		WD40	<1364..>1426	CDD:225201
		WD 9	1391..1431
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4155
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900