DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wda and Taf5l

DIOPT Version :9

Sequence 1:	NP_651136.1	Gene:	wda / 42750	FlyBaseID:	FBgn0039067	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001344244.1	Gene:	Taf5l / 102162	MGIID:	1919039	Length:	589	Species:	Mus musculus

Alignment Length:	724	Identity:	190/724 - (26%)
Similarity:	309/724 - (42%)	Gaps:	180/724 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KNDLLRCAVGLLLKQKNYVSNERFRRSDFLLLQNKQQFAVNKMLDTDLHGGNSFTFSNVQVITNN 99
            :.:.::.||...||::.||.:|...:....|.|..::.|.|..:.::....|:.:.:..|. ...
Mouse     5 RTEQVQVAVSCYLKRRQYVDSEGPLKQGLRLSQTPEEMAANLTVQSESGCANAVSAAPCQA-EPQ 68

  Fly   100 QHTVDQQFGRFSQFV-EAQAEPLRLEMKRFYGPMLCHFYLDLLKAREPRGAVELLRKYAHLVAPV 163
            |:.|  ||||...|: ::.::..|..|...| |:..:.:|:|::: .|:..||
Mouse    69 QYEV--QFGRLRSFLTDSDSQYSREVMPLLY-PLFVYLHLNLVQS-GPKSTVE------------ 117

  Fly   164 DMYDAPPPTKINGCSTTANESTFNIRFAKEAQDTGDTELDYFMRLVQTLSGYTRLEAAESDDTVA 228
            ..|                 |.|:..|.:.|......|.....:.:|.:....:|.|
Mouse   118 SFY-----------------SRFHGMFLQNASQKDVIEQLQTTQTIQDILSNFQLRA-------- 157

  Fly   229 HFRSSKYELHTTAVVVNRICAYLQRRGHVLIMNLLYTWLHVHIVENEQRAFSEDHLLGLTDDLEG 293
             |..:||.:.......|.:..|||...:..:..:|.  :|:|:
Mouse   158 -FLDNKYVVRLQEDSYNYLIRYLQSDNNTALCKVLA--VHIHL---------------------- 197

  Fly   294 EDGEDDVVSKPAVTLNTRGDIRPSK------------SLTEKSNRKRPAEEPNIMLETDIKQEVE 346
                               |::|:|            |.||.|:.: |.|.|:.:|:.:
Mouse   198 -------------------DVQPAKRTDYQLYASGGSSRTENSSLE-PPEVPSPILQNE------ 236

  Fly   347 TDESAELSKLQLNIDACLDTLKSA----------TEQILKSQVELPRFLRISERSRGLTSAHLDP 401
                |.|..||.:|....|...|.          |||:|.:       ..||..|:.|.
Mouse   237 ----AALEVLQESIKRVKDGPPSLTTICFYAFYNTEQLLNT-------AEISSDSKLLA------ 284

  Fly   402 SECHMLAGFDNSAVQLWQLNQSYCRGKSFYRRYPQKRCPWELNNCANQEEETDEDSSDEDVKCSE 466
                  ||||||.::||.|.....:.:..:....:.|...:    ..:|||.:||::..::|.
Mouse   285 ------AGFDNSCIKLWSLRSKKLKSEPHHVDTSRIRLACD----TLEEEENEEDNTGTEMKI-- 337

  Fly   467 EERRERNRARHCKYADNSYNEYGGFQLRGHTKGVTDVRFSAHYPLMYSVSKDATMRCWRAHNLHC 531
                                      ||||...|...||.|....:.|.|:|.::|.|...:...
Mouse   338 --------------------------LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTN 376

  Fly   532 AAIYRSHNYPIWCLDESPVGQYVVTGSKDLSARLWSLEKEHALIIYAGHTQDVECVAFHPNGNYI 596
            ..:|:.|.||:|.:|.||...|..:||.|.:|||||.::.:.|.|||||..||:||.||||.||:
Mouse   377 TVLYQGHAYPVWDVDISPFSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYL 441

  Fly   597 ATGSADHSVRLWCATSGKLMRVFADCRQAVTQLAFSPDGKMLAAAGEETKVRIFDLAAGAQLAEL 661
            ||||.|.:||||.|..|..:|:|...|..|..|:|||:||.||:|||:.:::::|||:|....||
Mouse   442 ATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLSFSPNGKYLASAGEDQRLKLWDLASGTLFKEL 506

  Fly   662 KDHSASISSLSWSTHNRHLATACSDGTLRLWDIKKLSPMSDNSSAGSSS------SATTNRVLTV 720
            :.|:.||:||::|..:..:|:|..|.::|:|||:  |...:..:.|||.      :...:.||:|
Mouse   507 RGHTDSITSLAFSPDSGLIASASMDNSVRVWDIR--STCCNTPADGSSGELVGVYTGQMSNVLSV 569

  Fly   721 N-SSCQRLV 728
            . .:|..|:
Mouse   570 QFMACNLLL 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wda	NP_651136.1	TAF5_NTD2	104..273	CDD:298747	33/169 (20%)
		WD40	324..>700	CDD:225201	128/385 (33%)
		WD40	491..700	CDD:238121	92/208 (44%)
		WD40 repeat	501..537	CDD:293791	9/35 (26%)
		WD40 repeat	542..578	CDD:293791	15/35 (43%)
		WD40 repeat	585..619	CDD:293791	20/33 (61%)
		WD40 repeat	626..662	CDD:293791	17/35 (49%)
Taf5l	NP_001344244.1	TAF5_NTD2	67..201	CDD:176269	36/218 (17%)
		WD 1	266..305		17/57 (30%)
		WD40	276..581	CDD:238121	120/349 (34%)
		WD 2	340..379		11/38 (29%)
		WD40 repeat	345..381	CDD:293791	9/35 (26%)
		WD 3	382..421		17/38 (45%)
		WD40 repeat	388..418	CDD:293791	13/29 (45%)
		WD 4	424..463		23/38 (61%)
		WD40 repeat	429..465	CDD:293791	21/35 (60%)
		WD 5	466..505		17/38 (45%)
		WD40 repeat	471..507	CDD:293791	17/35 (49%)
		WD 6	508..547		14/40 (35%)
		WD40 repeat	513..537	CDD:293791	8/23 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850836
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2449
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108737
Panther	1	1.100	-	-	O	PTHR19879
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5404
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.750