DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wda and taf5

DIOPT Version :9

Sequence 1:	NP_651136.1	Gene:	wda / 42750	FlyBaseID:	FBgn0039067	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	NP_001135586.1	Gene:	taf5 / 100216139	XenbaseID:	XB-GENE-1004611	Length:	777	Species:	Xenopus tropicalis

Alignment Length:	801	Identity:	194/801 - (24%)
Similarity:	305/801 - (38%)	Gaps:	219/801 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PSASNHAHAASPVYSNSNNNKSSASSKKTSSKNDLLRCAVGLLLKQKNYVSNERFRRSDFLLLQN 68
            |..:....||:|...      |.||.::|             ||....|:...:.:.|..:||:.
Frog    56 PGVAAPPAAAAPAPG------SDASDRQT-------------LLAVLQYLKKRKLKDSADILLRE 101

  Fly    69 KQQFAVNKML----------------DTDL----------------HGGNSFTFSNV---QVITN 98
            ...|..:::|                ||.|                .|..|.:.|:.   :|..|
Frog   102 SGLFDSDELLALTSLSPDRAGAGDGADTTLLSRVSGAAGSDISASAGGAASSSASSACAGKVTLN 166

  Fly    99 N----QHTV----------------DQQFGRFSQFVEAQAEPLRLEMKRFYGPMLCHFYLDLLKA 143
            |    |..|                ::.:....:|:|:..:..|.|:.:.:.|:..|.||:|:..
Frog   167 NGPQDQPDVSAVLSAYTQQGDPALYEEYYSGLKRFIESVLDCHRAELSQLFYPLFVHMYLELVYN 231

  Fly   144 REPRGAVELLRKYAHLVAPVDMYDAPPPTKINGCSTTANESTFNIRFAKEAQDTGDTELDY--FM 206
            :..:.|.....|: |                                       ||.|..|  .:
Frog   232 QHEQKAKSFFEKF-H---------------------------------------GDQECYYEDDL 256

  Fly   207 RLVQTLS--GYTRLEAAESDDTVAHFRSSKYELHTTAVVVNRICAYLQRRGHVLIMNLLYTWLHV 269
            |::.:||  |:..     .::|:..||:||:.|..:......:..:||.|.:..|.:::...|::
Frog   257 RILASLSKKGHMM-----GNETILDFRTSKFVLRISRDSYQLLKRHLQERQNNQIWSIVQEHLYI 316

  Fly   270 HIVENEQRAFSEDHLLGLTDDLEGE------------------------DGEDDVVSKPAVTLNT 310
            .|.:...|  |:..:..:...|.||                        |.||:.|.      |.
Frog   317 DIFDGMPR--SKQQIDAMVGSLSGEAKREANKAKIFFGLLKEPEIEVPLDDEDEEVE------NE 373

  Fly   311 RGDIRPSKSLTEKSN--RKRPAEEPNIMLETDIKQEVETDESAELSKLQLNIDACLDTLKSATEQ 373
            .|  :|.|...:|.|  .|...::||...:..|... |..:|.:|.|:.:        :|...::
Frog   374 EG--KPKKKKPKKDNVGSKSKKQDPNAPPQNRIPLP-ELKDSDKLDKIMI--------MKETAKR 427

  Fly   374 ILKSQVELPR--FLRISERSRGLTSAHLDPSECHMLAGFDNSAVQLWQLNQSYCRG-KSFYRRYP 435
            :...|..||.  |.......:|||:..:......:..||.:|.|::|.|.....|. ||
Frog   428 VRLGQDSLPSICFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSLTPKKLRSVKS------ 486

  Fly   436 QKRCPWELNNCANQEEETDEDSSD-----EDVKCSEEERRERNRARHCKYADNSYNEYGGFQLRG 495
                       |:.....|::|.|     .|.|.|.|.:                      .|.|
Frog   487 -----------ASDLSIIDKESDDVLERIMDEKSSSEMK----------------------VLYG 518

  Fly   496 HTKGVTDVRFSAHYPLMYSVSKDATMRCWRAHNLHCAAIYRSHNYPIWCLDESPVGQYVVTGSKD 560
            |:..|....||.....:.|.|:|.|:|.|......|...|:.||||:|....||.|.|.|:|..|
Frog   519 HSGPVYATSFSPDRNYLLSSSEDGTIRLWSLQTFTCLVAYKGHNYPVWDTQFSPYGYYFVSGGHD 583

  Fly   561 LSARLWSLEKEHALIIYAGHTQDVECVAFHPNGNYIATGSADHSVRLWCATSGKLMRVFADCRQA 625
            ..||||:.:....|.|:|||..||.|..||||.|||||||.|.:||||...:|..:|:|...:..
Frog   584 RVARLWATDHYQPLRIFAGHLADVICTRFHPNSNYIATGSTDRTVRLWDVLNGNCVRIFTGHKGP 648

  Fly   626 VTQLAFSPDGKMLAAAGEETKVRIFDLAAGAQLAELKDHSASISSLSWSTHNRHLATACSDGTLR 690
            :..|||:|:||.||....:.:|.::|:..|..:.|||.|:.::.:|.:|.....|::...|.|:|
Frog   649 IHSLAFTPNGKFLATGASDGRVLLWDIGHGLMVGELKGHTNTVYALRFSRDGEILSSVSMDNTVR 713

  Fly   691 LWDIKK----LSPMSDNSSAG 707
            |||..|    |......||||
Frog   714 LWDTVKAFEDLDTDDFTSSAG 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wda	NP_651136.1	TAF5_NTD2	104..273	CDD:298747	32/172 (19%)
		WD40	324..>700	CDD:225201	117/389 (30%)
		WD40	491..700	CDD:238121	83/212 (39%)
		WD40 repeat	501..537	CDD:293791	10/35 (29%)
		WD40 repeat	542..578	CDD:293791	14/35 (40%)
		WD40 repeat	585..619	CDD:293791	19/33 (58%)
		WD40 repeat	626..662	CDD:293791	12/35 (34%)
taf5	NP_001135586.1	TAF5_NTD2	188..320	CDD:176269	32/176 (18%)
		WD40	<426..716	CDD:225201	103/328 (31%)
		WD40	449..719	CDD:238121	101/308 (33%)
		WD40 repeat	450..507	CDD:293791	15/73 (21%)
		WD40 repeat	524..560	CDD:293791	10/35 (29%)
		WD40 repeat	565..601	CDD:293791	14/35 (40%)
		WD40 repeat	608..643	CDD:293791	19/34 (56%)
		WD40 repeat	649..685	CDD:293791	12/35 (34%)
		WD40 repeat	691..737	CDD:293791	15/44 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D230914at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19879
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020