DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wda and apaf1

DIOPT Version :9

Sequence 1:	NP_651136.1	Gene:	wda / 42750	FlyBaseID:	FBgn0039067	Length:	743	Species:	Drosophila melanogaster
Sequence 2:	XP_012815297.2	Gene:	apaf1 / 100127738	XenbaseID:	XB-GENE-988968	Length:	1248	Species:	Xenopus tropicalis

Alignment Length:	928	Identity:	170/928 - (18%)
Similarity:	304/928 - (32%)	Gaps:	308/928 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SLPSASNHAHAAS--------PVYSNSNNNKSSASSK------KTSSKNDLLRCAVGLLLKQKNY 52
            |||......|..|        .:.|...|.|:.|...      |.|..:.|:...:|.||:
Frog   272 SLPGFKEAVHVDSELEHSKGLEILSRFLNIKAEALPSQAHNIIKESKGSPLVVSLIGALLR---- 332

  Fly    53 VSNERFRRSDFLL--LQNKQQFAVNKMLDTDLHGGNSFTFSNVQVITNNQHTVDQQFGRFSQFVE 115
               |...|.||.|  |:.||...:.|....|                         :....:.:.
Frog   333 ---EFPTRWDFYLTQLKRKQFKRIRKSSSYD-------------------------YEALDEAMS 369

  Fly   116 AQAEPLRLEMKRFYG-------------PMLCHFYLDLLKAREPRGAVELLRKYAHLVAPVDMYD 167
            ...:.|:.:.|.:|.             .:||     :|...|.....::::::.:
Frog   370 ISVDNLKEDFKEYYNDFSIIEKDVKVPTQVLC-----ILWDMEREDVEDMMQEFVN--------- 420

  Fly   168 APPPTKINGCSTTANESTFNIRFAKEAQDTGDTELDYF------------MRLVQTLSGY--TRL 218
                ..:..|.......::.:.         |.:|||.            .:||.....:  ::.
Frog   421 ----KSLVYCDRNGKSYSYYLH---------DLQLDYLTERNRDRLTVLHSKLVDQYKKHYSSKS 472

  Fly   219 EAAESDDTVAHFRSSKYELHTTAVVVNRICAYLQRRGHVLIMNLLYTWLHV--------HIVENE 275
            .|.:.:|:|..:....|.: ..|.:...:|:.|.....:.....|:...|:        :|::|:
Frog   473 PAVDQEDSVYWYHYLAYHM-AKANMHQDLCSLLFSLNWLKAKTELFGTAHLIHEFVQYRNILDNQ 536

  Fly   276 ----QRAFSE-----DHLLGLTDDLE------GEDGEDDVVSKPAVTLNTRGDIRPSKSLTEKSN 325
                :..|.|     .||||...|:.      |: .||..|.|.|: |..:.:::.........|
Frog   537 NAKAREHFQEFIAVNGHLLGSNPDVSIVQLGLGQ-AEDSEVYKQAI-LQAKEELQSGALYVNWIN 599

  Fly   326 RKRPAEEPNIMLE----------------------TDIKQEVETDESAE-LSKLQLNIDACLDTL 367
            ::.....|.:::.                      .|...:|...|:.| |.:::.:.|..|...
Frog   600 KQSMKNLPTLVVRPHKDAVFHACFSSDGQRIASCGADKTLQVFKSETGEKLLEIEAHDDEVLCCA 664

  Fly   368 KSATEQILKSQVELPRFLRISERSRG----LTSAHLDPSEC---------HMLAGFDNSA-VQLW 418
            .||.|::| :.....|.::|.....|    :...|::...|         .:||...|.. ::||
Frog   665 FSADEKLL-ATCSADRKVKIWNAKTGKPLRVYEEHIEQVNCCQFTNGLSAPLLATCSNDCLIKLW 728

  Fly   419 QLNQSYCRG------KSFYR-RY-PQKRC-----------PWELNNCANQEEETD-------EDS 457
            ...::||..      :|.|. || |..|.           .|::.: ||:|:..:       ||.
Frog   729 NSEKNYCHNTLIGHIESVYHCRYSPDDRYLASSSMDGSLKIWDVES-ANEEKSIEVAKLFENEDE 792

  Fly   458 SDEDV--KC---SEEERRERNRARH--CKYADNSYNEYGGFQLRGHTKGVTDVRFS--------- 506
            :..:|  ||   |.:..|....||:  |.|.....|      |....|....:.:.
Frog   793 AQPEVLLKCCAWSNDGSRIMVTARNFLCIYDAERCN------LLSQLKACHQILYCDFCTTNQIA 851

  Fly   507 ----AHYPLMYSVSKDATMRCWRAHNLHCAAIYRSHNYPIWCLDESPVGQYVVTGSKDLSARLW- 566
                :||          .::.|...:....|.:.:|...:.|:..||.....:|.|.|.:.:||
Frog   852 ALALSHY----------VVQLWDIDSSTKIADFNAHLSWVHCVKFSPKSSSFLTSSDDQTVKLWE 906

  Fly   567 ----------------------------SLEKEHALIIYAGHT---------QD--VECVAFHPN 592
                                        :..|:..:::..|.|         ||  |.|.....:
Frog   907 TSNVSKPAATNLKREFDVTFSGERTLVLATSKDDCILLINGMTGETLSQIRAQDNCVTCCCLSTD 971

  Fly   593 GNYIATGSADHSVRLWCATSGKLMRVFADCRQAVTQLAFSPDGKMLAAAGEETKVRIFDLAAGAQ 657
            ....|.|..|..|::...:.|:::......|..|....|:.|||:|.::.::..||:::|.:|..
Frog   972 YQLAAIGHRDGKVKILDLSGGEILHKLDGHRDTVQHCQFTADGKLLVSSSDDCTVRVWNLVSGKN 1036

  Fly   658 LAELKDHSASI---------SSLSWSTHNRHLATACSDGTLRLWD------IKK----------- 696
            | ||..|...:         ...|||          .|||:::|:      ||:
Frog  1037 L-ELCGHKEPVKFFKILQESKVFSWS----------FDGTVKVWNLLTGQLIKEFICHSATVLAC 1090

  Fly   697 -LSPMSDN-SSAGSSSSA 712
             :||.|.. |||.:..||
Frog  1091 DISPDSTKFSSASTDKSA 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wda	NP_651136.1	TAF5_NTD2	104..273	CDD:298747	24/203 (12%)
		WD40	324..>700	CDD:225201	99/525 (19%)
		WD40	491..700	CDD:238121	52/288 (18%)
		WD40 repeat	501..537	CDD:293791	4/48 (8%)
		WD40 repeat	542..578	CDD:293791	9/64 (14%)
		WD40 repeat	585..619	CDD:293791	6/33 (18%)
		WD40 repeat	626..662	CDD:293791	12/35 (34%)
apaf1	XP_012815297.2	DD	7..92	CDD:417479
		NB-ARC	131..374	CDD:395745	25/133 (19%)
		APAF1_C	453..587	CDD:407760	27/136 (20%)
		WD40	610..906	CDD:238121	59/313 (19%)
		WD40 repeat	619..655	CDD:293791	5/35 (14%)
		WD40 repeat	660..697	CDD:293791	8/37 (22%)
		WD40 repeat	703..741	CDD:293791	8/37 (22%)
		WD40 repeat	746..788	CDD:293791	9/42 (21%)
		WD40 repeat	800..875	CDD:293791	15/90 (17%)
		WD40	871..1203	CDD:238121	54/249 (22%)
		WD40 repeat	881..916	CDD:293791	8/34 (24%)
		WD40 repeat	921..957	CDD:293791	3/35 (9%)
		WD40 repeat	963..1000	CDD:293791	7/36 (19%)
		WD40 repeat	1006..1041	CDD:293791	12/35 (34%)
		WD40 repeat	1046..1080	CDD:293791	9/43 (21%)
		WD40 repeat	1088..1123	CDD:293791	8/21 (38%)
		WD40 repeat	1129..1170	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910