Protein Alignment EloA and ELOA2

DIOPT Version :10

• Sequence 1: NP_732846.1
• Gene: EloA / 42749
• FlyBaseID: FBgn0039066
• Length: 643
• Species: Drosophila melanogaster
• Sequence 2: NP_057511.2
• Gene: ELOA2 / 51224
• HGNCID: 30771
• Length: 753
• Species: Homo sapiens
• Alignment Length: 791
• Identity: 180/791 - (22%)
• Similarity: 292/791 - (36%)
• Gaps: 187/791 - (23%)

  Fly     1 MASTSNLLDVVRHYQRSIEKHGEDEQRLLHCITKLFNLPIKFEHLQETGIGKTVNALRKISGEVG 65
            ||:.|..|..|...|..:....| .::|...:.||..||:..:.|.||||.|||..||| ...||
Human     1 MAAGSTTLHAVEKLQVRLATKTE-PKKLEKYLQKLSALPMTADILAETGIRKTVKRLRK-HQHVG 63

  Fly    66 VAAKTLVTKWKAMV--------AKEDPSIASTPTAIHNEEDSGKTKSSDEDPDQENKGGNSSSGE 122
            ..|:.|..:||.:|        ..:||           ||.:.:.:..:...|||...|...:..
Human    64 DFARDLAARWKKLVLVDRNTRPGPQDP-----------EESASRQRFGEALQDQEKAWGFPENAT 117

  Fly   123 DLNTSKHKSKHAKSTKHERSSSSRSHSKSRSDSDKKHK---------SSRHDKSKDRD---KDRE 175
            ...:..|..:|.::.:.......|.|.:|.|...:..:         |.|:..|..|.   :..|
Human   118 APRSPSHSPEHRRTARRTPPGQQRPHPRSHSREPRAERKCPRIAPADSGRYRASPTRTAPLRMPE 182

  Fly   176 GQKEAKEHKE----------------KKSNGEHKSKDSSKSSSSHKSSKSESHKSEHTKSKHE-- 222
            |.:.|...|:                ....|:.:.|.....|..||||:.|..........|.
Human   183 GPEPAAPGKQPGRGHTHAAQGGPLLCPGCQGQPQGKAVVSHSKGHKSSRQEKRPLCAQGDWHSPT 247

  Fly   223 --KDKTSHSELKE-------------------VKDKSSKHKSSSSKSSKRSHSPPRHEEESQKAK 266
              ::|:..:.|:|                   ..||......|..:......:|..|::..|.:
Human   248 LIREKSCGACLREETPRMPSWASARDRQPSDFKTDKEGGQAGSGQRVPALEEAPDSHQKRPQHS- 311

  Fly   267 IPKVKSKSEEDSADGFDSSMGANFDDVLGLLNIPISSKKSSSNSKSKFVAKPTAA----PSSSAL 327
                .|..:..|.||.|...|.:        .:....|:..||.:.....||..|    .|.|:|
Human   312 ----HSNKKRPSLDGRDPGNGTH--------GLSPEEKEQLSNDRETQEGKPPTAHLDRTSVSSL 364

  Fly   328 S------------------------------------APTTAGSSKEALSTSSRPTSKKPELLAS 356
            |                                    :.|||...|:..:..|:.|.   |...|
Human   365 SEVEEVDMAEEFEQPTLSCEKYLTYDQLRKQKKKTGKSATTALGDKQRKANESKGTR---ESWDS 426

  Fly   357 TAKLEPLD---------------------PNIALELPTISN-----NYKPMPLNQTVMDVVFNQG 395
            ..||.|:.                     .::..||..:|.     ||.|:    :..|.:.:|.
Human   427 AKKLPPVQESQSERLQAAGADSAGPKTVPSHVFSELWDLSEAWMQANYDPL----SDSDSMTSQA 487

  Fly   396 GSHKAQASRYFNESEALAQGISSKTMRTKIYSGVRTGQILQVPSLFDLCTRVLQKNIDALEYTGG 460
            ......:.::..|:....:.:::|   ..:|||.|....||||:|...|.:||:.|.|||...|.
Human   488 KPEALSSPKFREEAAFPGRRVNAK---MPVYSGSRPACQLQVPTLRQQCAQVLRNNPDALSDVGE 549

  Fly   461 VPFEVLRPVLERATPQQLLNFEEYNPYLMDDSDVLWQQHVQRHCRSQRREEMETWREMFLRCQEE 525
            ||:.||.||||...|.||...::.|..|:.::|.|.:.|..:..:.::.:|.:||||.:||..:.
Human   550 VPYWVLEPVLEGWRPDQLYRRKKDNHALVRETDELRRNHCFQDFKEEKPQENKTWREQYLRLPDA 614

  Fly   526 KDRKLSILAESIKASQKISEAPVRKTQLAFVDSMVKPPRSVQRKQEQYG-----TKGKLIATPAA 585
            .:::|.::..:|: |.:.:....|:.::....|:.|.|....|:||:..     ..|::  .||:
Human   615 PEQRLRVMTTNIR-SARGNNPNGREAKMICFKSVAKTPYDTSRRQEKSAGDADPENGEI--KPAS 676

  Fly   586 RVAALSSVTPNAAKVGDAR------LRVLAAAR-----DTAQVGAGP-------ARSKKAPLMAK 632
            :.|..|....:.:..|..|      ||.|...|     .::...|.|       |..|.||||||
Human   677 KPAGSSHTPSSQSSSGGGRDSSSSILRWLPEKRANPCLSSSNEHAAPAAKTRKQAAKKVAPLMAK 741

  Fly   633 TLQFMRGRLKR 643
            .::..:.|..|
Human   742 AIRDYKRRFSR 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EloA	NP_732846.1	Med26	30..79	CDD:462573	21/48 (44%)
		Elongin_A	455..552	CDD:462026	29/96 (30%)
ELOA2	NP_057511.2	TFS2N	8..77	CDD:197766	26/70 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	80..245		30/175 (17%)
		dnaA	<81..>205	CDD:455861	22/134 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..453		33/207 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..497		2/23 (9%)
		Activation domain. /evidence=ECO:0000250	500..659		50/162 (31%)
		BC-box. /evidence=ECO:0000250|UniProtKB:Q63187	528..537		2/8 (25%)
		Interacting with Elongin BC complex. /evidence=ECO:0000250	528..537		2/8 (25%)
		Elongin_A	544..642	CDD:462026	29/98 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	650..735		18/86 (21%)