Protein Alignment CG4467 and NPEPPS

DIOPT Version :10

• Sequence 1: NP_001036747.1
• Gene: CG4467 / 42747
• FlyBaseID: FBgn0039064
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: NP_001398059.1
• Gene: NPEPPS / 9520
• HGNCID: 7900
• Length: 924
• Species: Homo sapiens
• Alignment Length: 1037
• Identity: 234/1037 - (22%)
• Similarity: 401/1037 - (38%)
• Gaps: 236/1037 - (22%)

  Fly   130 PFPWLEKMLPTSVRPLRYMVTIHPNLTTLDVKGQVTIDLHVEKETNFIVLHIQDLNVTEKAIVTP 194
            ||    :.||..|.|:.|.:.:.|:|.....:|::.....|.:.||.||::..|:::...:....
Human    50 PF----ERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPE 110

  Fly   195 GPK-------GYALKIVKV-LEFPPRQQLYIEVKERLKKKSNYTLNLRWYSKLNPEPEGFYVDQY 251
            |.:       .|..:..|| |.||...|           ....||.:.:..:||.:.:|||..:|
Human   111 GDEEIHATGFNYQNEDEKVTLSFPSTLQ-----------TGTGTLKIDFVGELNDKMKGFYRSKY 164

  Fly   252 ESSNGVERLLAATVFRPNGARRAFPCFDEPHVRAPFRISVFRDRFHIGLSNSIVHTTEDVGFYMG 316
            .:.:|..|..|.|.|....|||||||:|||.::|.|.||:...:..:.|||  ::..:...:...
Human   165 TTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSN--MNVIDRKPYPDD 227

  Fly   317 TGLLRDDFIETPPLPADAVAWVVSDFQRESLQPSAAYIPTTPAPPGSGVGGKKSAQLNNYTQLKG 381
            ..|:...|..||.:....||:||.::.         ::.|.         .|....:..||
Human   228 ENLVEVKFARTPVMSTYLVAFVVGEYD---------FVETR---------SKDGVCVRVYT---- 270

  Fly   382 KNPPVRNITALTHSLNVNLTPRQNLTVVQPTTTTAWPVNLNGNGKPSNLTSLSQSTGSSIKRAPS 446
                                                ||.....||
Human   271 ------------------------------------PVGKAEQGK-------------------- 279

  Fly   447 YTFYAPRDLLIRSSFILHTSRDVLEYLQTWLDISYPLTKVDFVALPSLDRNMISSLGLVTLK-TS 510
                          |.|..:...|.:.:.:.::.|||.|:|.:|:.......:.:.||||.: |:
Human   280 --------------FALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETA 330

  Fly   511 FLTDPSSITSEQYQFSALRIAEAMVRQFFGGITSRKVLKDVWLWEGL---IQYLGIHALAPLQET 572
            .|.||.:..|...|:.||.:...:..|:||.:.:.:....:||.||.   |:||.:....|..:.
Human   331 LLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDI 395

  Fly   573 WPLREMYLLKMATAALDIDAIQGWDSIMNGTSHDGNNEEFF----VQKTAAIFSMLHTAIGEDRF 633
            |   ..::....|.|.::||:.....|.....|....:|.|    ..|.|::..|||..||:..|
Human   396 W---TQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDF 457

  Fly   634 RGCLGSFLKVNRFRTAEPTDLWTICTKKANGSKNIKDMMTLWTHQPGFPLLTV----TKMGNSIS 694
            :..:..:|...:.:.|...|||. ..:.|:| |.|..:|..||.|.||||:.|    .:....:.
Human   458 KKGMNMYLTKFQQKNAATEDLWE-SLENASG-KPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLR 520

  Fly   695 ISQRPFRPAEFLAIHDDSYDGNNYNKTTLNATDMPSTVATTTQGSKHKVAPHMKWIFPVTYVT-- 757
            :||:.|       ....||.|.          |.|                  :|:.|:|..|
Human   521 LSQKKF-------CAGGSYVGE----------DCP------------------QWMVPITISTSE 550

  Fly   758 DINNVSETLWMQNVDVTFNVPENVK---WIKVNAIQNGYYRVVYNDDNWASL---IEELAANPNR 816
            |.|.....:.|...::.. |.:|||   |:|:|....|:||..|:.....||   |.:|:..|
Human   551 DPNQAKLKILMDKPEMNV-VLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGIRDLSLPP-- 612

  Fly   817 FTSEDRLGMLSDAFTLCHANLLPCEITMNMIQYLPSETHYGPMALALRHLEKWRRILKYSECFLM 881
               .||||:.:|.|:|..|.::.....:.:::...:|.:|...:....:|.....:|.:::.:..
Human   613 ---VDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEE 674

  Fly   882 LSEFIKMKISTVMEKVGWS---DDGDVATRLLRPEVLLASVLWEDID------SITKAKNMLNQY 937
            :.||:|...|.:.|::||.   .:|.:       :.||..::...:.      ::.:|:.....:
Human   675 IQEFVKDVFSPIGERLGWDPKPGEGHL-------DALLRGLVLGKLGKAGHKATLEEARRRFKDH 732

  Fly   938 LYYNGTAI-PPNLREVVYTGSILSGEYIYWQHCWERFVNLQRTSETFVERMQLLRALGRTKDAWL 1001
            :  .|..| ..:||..||...:..|:    ....:..:.|.:.::...|:.::.|.||.|   .|
Human   733 V--EGKQILSADLRSPVYLTVLKHGD----GTTLDIMLKLHKQADMQEEKNRIERVLGAT---LL 788

  Fly  1002 QNRLLSHVTMLPTEEV-----VQVLKAIA-GTPTGGAMACRFLQAKWFELEKRLGPG-TISFAKV 1059
            .:.:...:|...:|||     |.|:..:| |:..|...|.:|::..|.||..|...| .||....
Human   789 PDLIQKVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQGGFLISRLIK 853

  Fly  1060 ISAITQYGATKFDYDELKSLVHRFGRGHGMSVLNMTLSSVASNVEWVARSQ---TSLYKWVE 1118
            :..:|......:|.:        .||...:.         :|.:.|....|   ..|.||:|
Human   854 VQWLTPVIPALWDAE--------VGRSPEVG---------SSRLSWPTCYQLRDLQLIKWLE 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4467	NP_001036747.1	GluZincin	145..677	CDD:472708	124/547 (23%)
		ERAP1_C	783..1078	CDD:463368	69/314 (22%)
NPEPPS	NP_001398059.1	M1_APN-Q_like	61..499	CDD:341064	124/547 (23%)
		ERAP1_C	578..854	CDD:463368	67/296 (23%)
		Nuclear localization signal. /evidence=ECO:0000255	726..730		0/3 (0%)