Protein Alignment CG4467 and AAP1

DIOPT Version :10

• Sequence 1: NP_001036747.1
• Gene: CG4467 / 42747
• FlyBaseID: FBgn0039064
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: NP_011913.1
• Gene: AAP1 / 856443
• SGDID: S000001089
• Length: 856
• Species: Saccharomyces cerevisiae
• Alignment Length: 1042
• Identity: 233/1042 - (22%)
• Similarity: 401/1042 - (38%)
• Gaps: 270/1042 - (25%)

  Fly   136 KMLPTSVRPLRYMVTIHPNLTTLDVKGQVTIDLHVEK-----------ETNFIVLHIQDLNVTE- 188
            ::||.:|.||.|.:|:.||......:|.:.|||.:..           |.:|....|:.:|..|
Yeast     4 EVLPNNVTPLHYDITLEPNFRAFTFEGSLKIDLQINDHSINSVQINYLEIDFHSARIEGVNAIEV 68

  Fly   189 -------KA-IVTP-------GPKGYALKIVKVLEFPPRQQLYIEVKERLKKKSNYTLNLRWYSK 238
                   || :|.|       ||..                               .|.:.:...
Yeast    69 NKNENQQKATLVFPNGTFENLGPSA-------------------------------KLEIIFSGI 102

  Fly   239 LNPEPEGFYVDQY-ESSNGVERLLAATVFRPNGARRAFPCFDEPHVRAPFRISVFRDRFHIGLSN 302
            ||.:..|||..:| :...|..:.:|.|......|||||||||||:::|.|.:::..:.|...|||
Yeast   103 LNDQMAGFYRAKYTDKVTGETKYMATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTHLSN 167

  Fly   303 SIVHTTEDVGFYMGTGLLRDDFIETPPLPADAVAWVVSDFQRESLQPSAAYIPTTPAPPGSGVGG 367
            ..|....     :..|.....|..||.:....||::|:|.:         |:
Yeast   168 MDVRNET-----IKEGKKYTTFNTTPKMSTYLVAFIVADLR---------YV------------- 205

  Fly   368 KKSAQLNNYTQLKGKNPPVRNITALTHSLNVNLTPRQNLTVVQPTTTTAWPVNLNGNGKPSNLTS 432
                :.||:
Yeast   206 ----ESNNF-------------------------------------------------------- 210

  Fly   433 LSQSTGSSIKRAPSYTFYAPRDLLIRSSFILHTSRDVLEYLQTWLDISYPLTKVDFVALPSLDRN 497
                      |.|...:..|.|... ..|..:.:...|.:.:...:|.|||.|:|.||:......
Yeast   211 ----------RIPVRVYSTPGDEKF-GQFAANLAARTLRFFEDTFNIEYPLPKMDMVAVHEFSAG 264

  Fly   498 MISSLGLVTLKT-SFLTDPSSITSEQYQFSALRIAEAMVRQFFGGITSRKVLKDVWLWEGLIQYL 561
            .:.:.||||.:. ..|.|..:.:.::.|..|..|...:..|:||.:.:....:.:||.||...::
Yeast   265 AMENWGLVTYRVIDLLLDIENSSLDRIQRVAEVIQHELAHQWFGNLVTMDWWEGLWLNEGFATWM 329

  Fly   562 GIHALAPLQETWPLREMYLLKMATAALDIDAIQGWDSIMNGTSH---------DGNNEEF---FV 614
            ..::....|..|.:.|.|:......||::|:::        :||         |..|:.|   ..
Yeast   330 SWYSCNKFQPEWKVWEQYVTDNLQRALNLDSLR--------SSHPIEVPVNNADEINQIFDAISY 386

  Fly   615 QKTAAIFSMLHTAIGEDRFRGCLGSFLKVNRFRTAEPTDLWTICTKKANGSKNIKDMMTLWTHQP 679
            .|.:::..|:...:||:.|...:..:|...::..|:..|||. ....|:| |::..:|.:||.:.
Yeast   387 SKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGDLWD-ALADASG-KDVCSVMNIWTKRV 449

  Fly   680 GFPLLTVTKMGNSISISQRPFRPAEFLAIHDDSYDGNNYNKTTLNATDMPSTVATTTQGSKHKVA 744
            |||:|:|.:..|.|:::|..:                      |:..|:.....||
Yeast   450 GFPVLSVKEHKNKITLTQHRY----------------------LSTGDVKEEEDTT--------- 483

  Fly   745 PHMKWIFPVTY-VTDINNVSETLWMQNVDVTFNVPENVKWIKVNAIQNGYYRVVYNDDNWASLIE 808
                 |:|:.. :.|...:..||.:.....||.: :|.::.|:|..|:|.:...|:|:.||
Yeast   484 -----IYPILLALKDSTGIDNTLVLNEKSATFEL-KNEEFFKINGDQSGIFITSYSDERWA---- 538

  Fly   809 ELAANPNRFTSEDRLGMLSDAFTLCHANLLPCEITMNMIQYLPSETHYGPMALALRHLEKWRRI- 872
            :|:...|..:.|||:|:::||..|..:........:|:|....:|..:          ..|.:|
Yeast   539 KLSKQANLLSVEDRVGLVADAKALSASGYTSTTNFLNLISNWKNEDSF----------VVWEQII 593

  Fly   873 -----LKYSECFL---MLSEFIKMKISTVMEK---VGWSDDGDVATRLLRPEVLLASVLW----E 922
                 ||.:..|.   :|:...|..:..|:.|   :||:...|.:..:.|.:|.|.|...    |
Yeast   594 NSLSALKSTWVFEPEDILNALDKFTLDLVLNKLSELGWNIGEDDSFAIQRLKVTLFSAACTSGNE 658

  Fly   923 DIDSITKAKNMLNQYLYYNGTAIPPNLREVVY-TGSILSGEYIYWQHCWERFVNLQRTSETFVER 986
            .:.||  |..|..:|...|..|||...:.||: |.:.|.||..|     |:..|:.:...:..|:
Yeast   659 KMQSI--AVEMFEEYANGNKQAIPALFKAVVFNTVARLGGENNY-----EKIFNIYQNPVSSEEK 716

  Fly   987 MQLLRALGRTKDAWLQNRLLSHV---TMLPTEEVVQVLKAIAGTPTGGAMACRFLQAKWFELEKR 1048
            :..||||||.:|..|..|.||::   |:| .::....::.|.....|......::|..|.|:.||
Yeast   717 IIALRALGRFEDKELLERTLSYLLDGTVL-NQDFYIPMQGIRVHKKGIERLWAWMQEHWDEIAKR 780

  Fly  1049 LGPGTISFAKVISAITQYGATKF-DYDELKSLVHRFGR----GHGMSVLNMTLSSVASNVEWVAR 1108
            |.||    :.|:..:...|.|.| .::.|:.:...:.|    |...: |...|.::.|..:||:|
Yeast   781 LQPG----SPVLGGVLTLGLTNFTSFEALEKISAFYSRKVTKGFDQT-LAQALDTIRSKAQWVSR 840

  Fly  1109 SQ 1110
            .:
Yeast   841 DR 842

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4467	NP_001036747.1	GluZincin	145..677	CDD:472708	116/572 (20%)
		ERAP1_C	783..1078	CDD:463368	84/315 (27%)
AAP1	NP_011913.1	M1_APN-Q_like	13..447	CDD:341064	116/572 (20%)
		ERAP1_C	517..833	CDD:463368	88/342 (26%)