Protein Alignment CG4467 and TMA108

DIOPT Version :10

• Sequence 1: NP_001036747.1
• Gene: CG4467 / 42747
• FlyBaseID: FBgn0039064
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: NP_012129.1
• Gene: TMA108 / 854669
• SGDID: S000001399
• Length: 946
• Species: Saccharomyces cerevisiae
• Alignment Length: 1087
• Identity: 214/1087 - (19%)
• Similarity: 377/1087 - (34%)
• Gaps: 323/1087 - (29%)

  Fly   138 LPTSVRPLRY--MVTIHPNLTTLDVKGQVTIDL----------HVEKETNFIVLHIQDLNVTEKA 190
            |...|.|..|  .:.|.|..::.:.||...|.|          .:|.......||.:|| :...|
Yeast     8 LENPVVPSHYELRLEIDPKQSSPNFKGSAIIHLKFNPNSTTLASIEDSFTQFKLHSKDL-IVLSA 71

  Fly   191 IVTPGPKGYALKIVKVLEFPPRQQLYIEVKERLKKKSN---YTLNLRWYSKL------NPEPEGF 246
            ..|.|...:.|||.:    ...:.|.|...|...:.||   ..|::::..|:      :.:..|.
Yeast    72 HATIGSTKFDLKISQ----DTGKHLSIFNSESPIQLSNDCPLILSVQYVGKIRDIKTHHDKTFGI 132

  Fly   247 YVDQY--ESSNGVERLLAATVFRPNGARRAFPCFDEPHVRAPFRISVFRDRFHIGLSNSIVHTTE 309
            :...:  ..:......:.||..:|..|...|||.|||..::.|::::..|..:..:||:.|...|
Yeast   133 FKTNFMDRKTGTANNHVVATHCQPFSASNIFPCIDEPSNKSTFQLNIATDAQYKAVSNTPVEMVE 197

  Fly   310 DVGFYMGTGLLRDDFIETPPLPADAVAWVVSDFQRESLQPSAAYIPTTPAPPGSGVGGKKSAQLN 374
            .:.... ..|::  |.:||.:......:.:.|.:         ::.|
Yeast   198 ALDSSQ-KHLVK--FAKTPLMTTSVFGFSIGDLE---------FLKT------------------ 232

  Fly   375 NYTQLKGKNPPVRNITALTHSLNVNLTPRQNLTVVQPTTTTAWPVNLNGNGKPSNLTSLSQSTGS 439
                                                       .:.|.|:
Yeast   233 -------------------------------------------EIKLEGD--------------- 239

  Fly   440 SIKRAPSYTFYAPRDLLIRSSFILHTSRDVLEYLQTWLDISYPLTKVDFVALPSLDRNMISSLGL 504
               |....:.|||.| :..::|.|.|.:..|..|:::....|||.|:|||.||.|....:.:.|:
Yeast   240 ---RTIPVSIYAPWD-IANAAFTLDTVQKYLPLLESYFKCPYPLPKLDFVLLPYLSDMAMENFGM 300

  Fly   505 VTLKTS-FLTDPSSITSEQYQFSALR-IAEAMVRQFFGGITSRKVLKDVWLWEGLIQYLGIHAL- 566
            :|::.: .|..|:::.:|..:..|.: |...:|.|:.|...|....:.:|..|....:|..|.|
Yeast   301 ITIQLNHLLIPPNALANETVREQAQQLIVHELVHQWMGNYISFDSWESLWFNESFATWLACHILE 365

  Fly   567 --APLQETWPLREMYLLK-----MATAALDIDAIQGWDSIMNGTSHDGNNEEFF----VQKTAAI 620
              ..|...| ..|.|||:     |...|.|::....:......|..|....:.|    ..|...:
Yeast   366 QNGDLSHYW-TSEPYLLQQVEPTMCRDAADVNGRSIFQIAQRNTGIDSQTSDIFDPEAYTKGIIM 429

  Fly   621 FSMLHTAIGEDRFRGCLGSFL---KVNRFRTAEPTDLWTICTKKANGSKNIKDMMTLWTHQPGFP 682
            ...|..|.||...:..|.|..   |....|:.:|.|:|....|... |:||.:.::.||..||.|
Yeast   430 LRSLQLATGESHLQKGLESVFEDTKTFHARSVKPMDIWNHIGKFLK-SQNITNFVSSWTRTPGLP 493

  Fly   683 LLTVTKMGNSISISQRPFRPAEFLAIHDDSYDGNNYNKTT----LNATDMPSTVATTTQGSKHKV 743
            ::       .:.:.::               ||....|.|    :|.       .:|.:..:.:.
Yeast   494 VV-------KVEVEEK---------------DGKTQTKLTQHRFINQ-------LSTEEKDQLED 529

  Fly   744 APHMKWIFPVTYVTDINNVSETLWMQNVDVTFNVPENVKWIKVNAIQNGYYRVVYNDDNWASLIE 808
            .|:...:|.|  :.|....::.:.:.:..:.|:.|..|    :|.:..|||||.|..:...:||.
Yeast   530 VPYQVPLFGV--LPDGKMDTKNVLLTDRTLKFDYPILV----INHLAQGYYRVSYESEECYALIN 588

  Fly   809 ELAANPNRFTSEDRLGMLSDAFTLCHANLLPCEITMNMIQYLPSE-----THYGPMALALRH--- 865
            :      :.|.|          ||...:|.  :|.:::.|::..|     .|...:...|.|
Yeast   589 D------KITEE----------TLSEIDLR--KIFLDLSQFIGDEGFQNSIHLHGLFKILNHIAS 635

  Fly   866 ----------------LEKWRRILKYSECFLMLSEFIKMKI-STVMEKVGW-SDDGDVATRLLRP 912
                            ||..:.|.:.|.....|..|:|.|| ..:..|:.| ..:.|.:|   .|
Yeast   636 PSTKIASKYWDPLSKGLEVLQTIDRASLTSSKLQSFLKKKIVIPLFNKIDWPHGEFDKST---NP 697

  Fly   913 EVL--LASVLWEDIDSITKAKNMLNQYLYY--NG--TAIPPNLREVVYTGSILSGEYIYWQHC-- 969
            ..|  ::.||:.:.:| .|...:...|..:  .|  :::|..|     ..|||   .:..|||
Yeast   698 HELKVMSQVLFLNKNS-AKCAELCQIYFKHLLQGPRSSVPLEL-----VNSIL---VVVSQHCAN 753

  Fly   970 ---WERFVNL------------------QRTSET-FVERMQLLRALGRTKDAWLQNRLLSHVTM- 1011
               |::..:|                  |.:||| .:.:...:.:||...|:.:..:.|:.:|.
Yeast   754 IKQWKKIFDLVKRSSCTGITNHVINMYDQNSSETAMLIQNGAIESLGFCLDSDIVKKTLNFITSN 818

  Fly  1012 -------------------------LPTEEVVQ--------------VLKAI-AGTPTGGAM--A 1034
                                     .|.::||:              ..||. .||.||..:  |
Yeast   819 IESEGMELALFGFNYNFKKRLNKNEKPQDQVVRETIWEWYMGNFDQWARKATRKGTTTGDHLHKA 883

  Fly  1035 CRFLQ---------------AKWFELEK-RLGPGTISFAKVISAITQ 1065
            .|.:.               .|:..||| :||...:|...:.:::.|
Yeast   884 LRSISLIIFQMFVADEPQKIEKFINLEKEKLGQSLLSLDDIWASVQQ 930

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4467	NP_001036747.1	GluZincin	145..677	CDD:472708	115/571 (20%)
		ERAP1_C	783..1078	CDD:463368	79/398 (20%)
TMA108	NP_012129.1	M1_APN-Q_like	15..488	CDD:341064	115/571 (20%)
		ERAP1_C	564..924	CDD:463368	79/393 (20%)