Protein Alignment CG4467 and APE2

DIOPT Version :10

• Sequence 1: NP_001036747.1
• Gene: CG4467 / 42747
• FlyBaseID: FBgn0039064
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: NP_012765.3
• Gene: APE2 / 853699
• SGDID: S000001640
• Length: 952
• Species: Saccharomyces cerevisiae
• Alignment Length: 1020
• Identity: 231/1020 - (22%)
• Similarity: 399/1020 - (39%)
• Gaps: 205/1020 - (20%)

  Fly   136 KMLPTSVRPLRYMVTIHPNLTTLDVKGQVTIDLHVEKET-NFIVLHIQDL--------NVTEKAI 191
            ::||.:|.||.|.:|:.|:..|...:|.|.|:|.:.... :.:.|:..|.        :||...|
Yeast   100 EILPDNVVPLHYDLTVEPDFKTFKFEGSVKIELKINNPAIDTVTLNTVDTDIHSAKIGDVTSSEI 164

  Fly   192 VTPGPKGYALKIVKVLEFPPRQQLYIEVKERLKK-KSNYTLNLRWYSKLNPEPEGFYVDQYESS- 254
            ::...:.     |....||         |..:.. |.|..|::::...||....|||..:||..
Yeast   165 ISEEEQQ-----VTTFAFP---------KGTMSSFKGNAFLDIKFTGILNDNMAGFYRAKYEDKL 215

  Fly   255 NGVERLLAATVFRPNGARRAFPCFDEPHVRAPFRISVFRDRFHIGLSNSIVHTTEDVGFYMGTGL 319
            .|..:.:|.|...|..|||||||||||:::|.|.|::..|.....|||..|...     |:..|.
Yeast   216 TGETKYMATTQMEPTDARRAFPCFDEPNLKASFAITLVSDPSLTHLSNMDVKNE-----YVKDGK 275

  Fly   320 LRDDFIETPPLPADAVAWVVSDFQRESLQPSAAYIPTTPAPPGSGVGGKKSAQLNNYTQLKGKNP 384
            ....|..||.:....||::|::.:                                |.:.|....
Yeast   276 KVTLFNTTPKMSTYLVAFIVAELK--------------------------------YVESKNFRI 308

  Fly   385 PVRNITALTHSLNVNLTPRQNLTVVQPTTTTAWPVNLNGNGKPSNLTSLSQSTGSSIKRAPSYTF 449
            |||          |..||                    ||.|
Yeast   309 PVR----------VYATP--------------------GNEK----------------------- 320

  Fly   450 YAPRDLLIRSSFILHTSRDVLEYLQTWLDISYPLTKVDFVALPSLDRNMISSLGLVTLK-TSFLT 513
                    ...|....:...|.:.:....|.|||.|:|.||:.......:.:.||||.: ...|.
Yeast   321 --------HGQFAADLTAKTLAFFEKTFGIQYPLPKMDNVAVHEFSAGAMENWGLVTYRVVDLLL 377

  Fly   514 DPSSITSEQYQFSALRIAEAMVRQFFGGITSRKVLKDVWLWEGLIQYLGIHALAPLQETWPLREM 578
            |..:.|.::.|..|..:...:..|:||.:.:....:.:||.||...::..::....|..|.:.|.
Yeast   378 DKDNSTLDRIQRVAEVVQHELAHQWFGNLVTMDWWEGLWLNEGFATWMSWYSCNEFQPEWKVWEQ 442

  Fly   579 YLLKMATAALDIDAIQGWDSIMNGTSH---------DGNNEEF---FVQKTAAIFSMLHTAIGED 631
            |:......||.:|:::        :||         |..|:.|   ...|.|::..|:...:||:
Yeast   443 YVTDTLQHALSLDSLR--------SSHPIEVPVKKADEINQIFDAISYSKGASLLRMISKWLGEE 499

  Fly   632 RFRGCLGSFLKVNRFRTAEPTDLWTICTKKANGSKNIKDMMTLWTHQPGFPLLTVTKMGNSISIS 696
            .|...:..:|...::..|:..|||. ....|:| |:::.:|.:||.:.|||:::|::.||    .
Yeast   500 TFIKGVSQYLNKFKYGNAKTEDLWD-ALADASG-KDVRSVMNIWTKKVGFPVISVSEDGN----G 558

  Fly   697 QRPFRPAEFLAIHDDSYDGNNYNKTTLNATDMPSTVATTTQGSKHKVAPHMKWIFPVTYVTDI-N 760
            :..||...:|:..|...|.:                               |.|:||...... |
Yeast   559 KITFRQNRYLSTADVKPDED-------------------------------KTIYPVFLALKTKN 592

  Fly   761 NVSETLWMQNVDVTFNVPENVKWIKVNAIQNGYYRVVYNDDNWASLIEELAANPNRFTSEDRLGM 825
            .|..::.:.....|..: |:..:.|||:.|:|.|...|.|:.||    :|....:..:.|||:|:
Yeast   593 GVDSSVVLSERSKTIEL-EDPTFFKVNSEQSGIYITSYTDERWA----KLGQQADLLSVEDRVGL 652

  Fly   826 LSDAFTLCHANLLPCEITMNMIQYLPSETHYGPMALALRHLEKWRR--ILKYSECFLMLSEFIKM 888
            ::|..||..:........:|::....:|..:......:..:...:.  :.:..|....|..|.|.
Yeast   653 VADVKTLSASGYTSTTNFLNLVSKWNNEKSFVVWDQIINSISSMKSTWLFEPKETQDALDNFTKQ 717

  Fly   889 KISTVMEKVGW---SDDGDVATRLLRPEVLLASVLWEDIDSITKAKNMLNQYLYYNGTAIPPNLR 950
            .||.:...:||   |.| ..:|:.|:..:..|:....|.|....|..|...|...|..|||..::
Yeast   718 LISGMTHHLGWEFKSSD-SFSTQRLKVTMFGAACAARDADVEKAALKMFTDYCSGNKEAIPALIK 781

  Fly   951 EVVY-TGSILSGEYIYWQHCWERFVNLQRTSETFVERMQLLRALGRTKDAWLQNRLLSHV---TM 1011
            .:|: |.:.:.|...|     |:...:.....:..|::..||:|||.|:..|..|.|.::   |:
Yeast   782 PIVFNTVARVGGAENY-----EKVYKIYLDPISNDEKLAALRSLGRFKEPKLLERTLGYLFDGTV 841

  Fly  1012 LPTEEVVQVLKAIAGTPTGGAMACRFLQAKWFELEKRLGPGTISFAKVISAITQYGATKFDYDEL 1076
            | .:::...::.:.....|......:::..|.||.|||.||......|::..|....:....||:
Yeast   842 L-NQDIYIPMQGMRAHQEGVEALWNWVKKNWDELVKRLPPGLSMLGSVVTLGTSGFTSMQKIDEI 905

  Fly  1077 KS-LVHRFGRGHGMSVLNMTLSSVASNVEWVARSQTSLYKWVEGN 1120
            |. ...:..:|...| |..:|.::.|..:||.|.:..:.|:::.|
Yeast   906 KKFFATKSTKGFDQS-LAQSLDTITSKAQWVNRDRDVVNKYLKEN 949

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4467	NP_001036747.1	GluZincin	145..677	CDD:472708	124/555 (22%)
		ERAP1_C	783..1078	CDD:463368	72/303 (24%)
APE2	NP_012765.3	M1_APN-Q_like	109..543	CDD:341064	124/555 (22%)
		ERAP1_C	614..928	CDD:463368	77/325 (24%)