Protein Alignment CG4467 and AOPEP

DIOPT Version :10

• Sequence 1: NP_001036747.1
• Gene: CG4467 / 42747
• FlyBaseID: FBgn0039064
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: NP_001372995.1
• Gene: AOPEP / 84909
• HGNCID: 1361
• Length: 859
• Species: Homo sapiens
• Alignment Length: 729
• Identity: 150/729 - (20%)
• Similarity: 233/729 - (31%)
• Gaps: 282/729 - (38%)

  Fly   464 HTSRDVLEYLQTWLDIS-YPLTKVDFVALPSLDRNMISSLGLVTLKTSFLTDPS-SITSEQYQFS 526
            |.|.|.|..|.. .|:| ..:.:||..|:|.|::              |...|. ::.||:::
Human   137 HGSEDFLLVLDC-CDLSVLKVEEVDVAAVPGLEK--------------FTRSPELTVVSEEFR-- 184

  Fly   527 ALRIAEAMVRQFFGGITSRKVLKDVWLWEGLIQYLGIHALAP-------LQETWPLREMYLLKM- 583
                 ..:||:......:|        |...:.|....:.||       ..:||.|:   :.|.
Human   185 -----NQIVRELVTLPANR--------WREQLDYYARCSQAPGCGELLFDTDTWSLQ---IRKTG 233

  Fly   584 ATAALDI-DAIQGW-------DSIMNGTSHDG-----------NNEEFF--------------VQ 615
            |..|.|. .||:.|       .|:...:...|           ||...|              ..
Human   234 AQTATDFPHAIRIWYKTKPEGRSVTWTSDQSGRPCVYTVGSPINNRALFPCQEPPVAMSTWQATV 298

  Fly   616 KTAAIFSMLHTAIGEDRFRGCLGSFLKVNRFRTAEPTDLWTICTKKANGSKNIKDMMTLWTHQPG 680
            :.||.|.:|.:  ||:                :|:||.||..|:.              |.:...
Human   299 RAAASFVVLMS--GEN----------------SAKPTQLWEECSS--------------WYYYVT 331

  Fly   681 FPL-----------LTVTKM----GNSISISQRPFRPAEFLAIHDDSYDGNNYNKTTLNATDMPS 730
            .|:           .|..||    .|.:: ::|||.|:|....|........|.....||
Human   332 MPMPASTFTIAVGCWTEMKMETWSSNDLA-TERPFSPSEANFRHVGVCSHMEYPCRFQNA----- 390

  Fly   731 TVATTTQGSKHKVAPHMKWIFPVTYVTDINNVSETLWMQNVDVTFNVPENVKWIKVNAIQNGYYR 795
              :.|||    ::.||.  :|....:|  ....||| ::.:....:...:|    :.|.......
Human   391 --SATTQ----EIIPHR--VFAPVCLT--GACQETL-LRLIPPCLSAAHSV----LGAHPFSRLD 440

  Fly   796 VVYNDDNWASLIEELAANPNRFTSEDRLGMLSDAFTLCHANLLPC-EITMNMIQYLPSETHYGPM 859
            |:....|:.||  .:|:....|.|:   .:|:....||...|  | ||         :...:| :
Human   441 VLIVPANFPSL--GMASPHIMFLSQ---SILTGGNHLCGTRL--CHEI---------AHAWFG-L 488

  Fly   860 ALALRH-LEKWRRILKYSECFLMLSEFIKMKISTVMEKVGWSDDGDVATRLLRPEVLLASVLWED 923
            |:..|. .|:|            |||    ..:|.:|.|.|:....:|....|.:..|.:.|
Human   489 AIGARDWTEEW------------LSE----GFATHLEDVFWATAQQLAPYEAREQQELRACL--- 534

  Fly   924 IDSITKAKNMLNQYLYYNGTAIPPNLREVVYTGSILSGEYIYWQHCWERFVNLQRTSETFVERMQ 988
                                                         .|.|   ||...:...|.||
Human   535 ---------------------------------------------RWRR---LQDEMQCSPEEMQ 551

  Fly   989 LLR----ALGRTKDAWLQNRLLSHVTMLPTEEVVQV--LKAIAGTPTGGAMACRFLQAKWFELEK 1047
            :||    ..|.|.|:...  ::.| .:.|.:..:||  ||        |....||       |.|
Human   552 VLRPSKDKTGHTSDSGAS--VIKH-GLNPEKIFMQVHYLK--------GYFLLRF-------LAK 598

  Fly  1048 RLGPGT-ISFAKVISAITQYGATKFDYDELKSLVHRFGRGHGMSVLNMT-LSSVASNVEWVARSQ 1110
            |||..| .||                   |:..||.|   ||..:|:.. |..:..|:....|.:
Human   599 RLGDETYFSF-------------------LRKFVHTF---HGQLILSQDFLQMLLENIPEEKRLE 641

  Fly  1111 TS---LYK-WVEGN 1120
            .|   :|: |:|.:
Human   642 LSVENIYQDWLESS 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4467	NP_001036747.1	GluZincin	145..677	CDD:472708	51/255 (20%)
		ERAP1_C	783..1078	CDD:463368	61/303 (20%)
AOPEP	NP_001372995.1	GluZincin	<244..652	CDD:472708	117/584 (20%)
		Nucleolar localization signal. /evidence=ECO:0000250|UniProtKB:Q8BXQ6	689..699
		Leuk-A4-hydro_C	721..>771	CDD:462686