Protein Alignment CG4467 and Anpep

DIOPT Version :10

• Sequence 1: NP_001036747.1
• Gene: CG4467 / 42747
• FlyBaseID: FBgn0039064
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: NP_112274.1
• Gene: Anpep / 81641
• RGDID: 2991
• Length: 965
• Species: Rattus norvegicus
• Alignment Length: 1127
• Identity: 258/1127 - (22%)
• Similarity: 450/1127 - (39%)
• Gaps: 249/1127 - (22%)

  Fly    72 RALLVAGIVLGSLLLTAII---IAYAGPQN---DCSCGSKTVSGYETDEENNTQPFNPIATNGEP 130
            :.|.:.||:||...:..||   :.||..:|   :.|..:.|:.|..:...:.|.|     ...|.
  Rat     9 KTLGILGILLGVAAVCTIIALSVVYAQEKNRNAENSAIAPTLPGSTSATTSTTNP-----AIDES 68

  Fly   131 FPWLEKMLPTSVRPLRYMVTIHPNLTTLD-----VKGQVTIDLHVEKETNFIVLHIQDLNVTEKA 190
            .||.:..||.::.|..|.||:.|.||..:     .||..|:.....:.||.|::|.:.||.|.|.
  Rat    69 KPWNQYRLPKTLIPDSYQVTLRPYLTPNEQGLYIFKGSSTVRFTCNETTNVIIIHSKKLNYTNKG 133

  Fly   191 I---------VTPGPKGYALKIVKVLEFPPRQQLYIEVKERLKKKSNYTLNLRWYSKLNPEPEGF 246
            .         .||.|.....::|:..|:     |.:.::..|.|...|.::..:..:|..:..||
  Rat   134 NHRVALRALGDTPAPNIDTTELVERTEY-----LVVHLQGSLVKGHQYEMDSEFQGELADDLAGF 193

  Fly   247 YVDQYESSNGVERLLAATVFRPNGARRAFPCFDEPHVRAPFRISVFRDRFHIGLSNSIVHTT--- 308
            |..:| ...|.::::|.|..:...||::|||||||.::|.|.|::........|||.:...:
  Rat   194 YRSEY-MEGGNKKVVATTQMQAADARKSFPCFDEPAMKASFNITLIHPNNLTALSNMLPKDSRTL 257

  Fly   309 -EDVGFYMGTGLLRDDFIETPPLPADAVAWVVSDFQR-ESLQPSAAYIPTTPAPPGSGVGGKKSA 371
             ||..:.:      .:|..||.:....:|::||:|:. |::.|
  Rat   258 QEDPSWNV------TEFHPTPKMSTYLLAYIVSEFKYVEAVSP---------------------- 294

  Fly   372 QLNNYTQLKGKNPPVRNITALTHSLNVNLTPRQNLTVVQPTTTTAWPVNLNGNGKPSNLTSLSQS 436
               |..|::                                   .|       .:||   ::.:.
  Rat   295 ---NRVQIR-----------------------------------IW-------ARPS---AIDEG 311

  Fly   437 TGSSIKRAPSYTFYAPRDLLIRSSFILHTSRDVLEYLQTWLDISYPLTKVDFVALPSLDRNMISS 501
            .|                     .:.|..:..:|.:.....:.:|||.|.|.:|||..:...:.:
  Rat   312 HG---------------------DYALQVTGPILNFFAQHYNTAYPLEKSDQIALPDFNAGAMEN 355

  Fly   502 LGLVTLKTSFLT-DPSSITSEQYQFSALRIAEAMVRQFFGGITSRKVLKDVWLWEGL---IQYLG 562
            .||||.:.|.|. ||.|.:....:.....||..:..|:||.:.:.....|:||.||.   :::||
  Rat   356 WGLVTYRESALVFDPQSSSISNKERVVTVIAHELAHQWFGNLVTVDWWNDLWLNEGFASYVEFLG 420

  Fly   563 IHALAPLQETWPLREMYLLKMATAALDIDAIQG---WDSIMNGTSHDGNNEEFF----VQKTAAI 620
            .....|   ||.|:::.:|......:.:||:..   ..|..|..:......|.|    ..|.|::
  Rat   421 ADYAEP---TWNLKDLIVLNDVYRVMAVDALASSHPLSSPANEVNTPAQISELFDSITYSKGASV 482

  Fly   621 FSMLHTAIGEDRFRGCLGSFLKVNRFRTAEPTDLWTICTKKANGSKNIK------DMMTLWTHQP 679
            ..||.:.:.||.|:..|.|:|...::......|||....:..:....||      .:|..|..|.
  Rat   483 LRMLSSFLTEDLFKKGLSSYLHTFQYSNTIYLDLWEHLQQAVDSQTAIKLPASVSTIMDRWILQM 547

  Fly   680 GFPLLTV-TKMGN------SISISQRPFRPAEFLAIHDDSYDGNNYNKTTLNATDMPSTVATTTQ 737
            |||::|| |..|.      .:..:.:|.||::|           ||
  Rat   548 GFPVITVNTSTGEIYQEHFLLDPTSKPTRPSDF-----------NY------------------- 582

  Fly   738 GSKHKVAPHMKWIFPVTYVTDINNVSETLWMQ---NVDVTFNVPENVKWIKVNAIQNGYYRVVYN 799
                      .||.|:.|:.  |...:..|::   |....|....| :|:.:|....|||:|.|:
  Rat   583 ----------LWIVPIPYLK--NGKEDHYWLETEKNQSAEFQTSSN-EWLLLNINVTGYYQVNYD 634

  Fly   800 DDNWASLIEELAANPNRFTSEDRLGMLSDAFTLCHANLLPCEITMNMIQYLPSETHYGPMALALR 864
            ::||..:..:|..:.:.....:|..::.|:|.|..|..|...:.::...:|.|||.|.|...||.
  Rat   635 ENNWRKIQNQLQTDLSVIPVINRAQIIHDSFNLASAGKLSITLPLSNTLFLASETEYMPWEAALS 699

  Fly   865 HLEKWRRILKYSECFLMLSEFIKMKISTV-----MEKVGWSDDGDVATRLLRPEVLLASVLWEDI 924
            .|..::.:...||.:..:..::|.:::.:     ::...|.|         ||..|:..  :.:|
  Rat   700 SLNYFKLMFDRSEVYGPMKRYLKKQVTPLFAYFKIKTNNWLD---------RPPTLMEQ--YNEI 753

  Fly   925 DSITKA------------KNMLNQYL-YYNGTAIPPNLREVVYTGSILSGEYIYWQHCWERFVNL 976
            ::|:.|            ..:.:|:: ..:...|.||||..||..:|..|....|...||:|
  Rat   754 NAISTACSSGLEECRDLVVGLYSQWMNNSDNNPIHPNLRSTVYCNAIAFGGEEEWNFAWEQF--- 815

  Fly   977 QRTSETFVERMQLLR-ALGRTKDAWLQNRLLSHVTMLP----TEEVVQVLKAIAGTPTGGAMACR 1036
              ...|.|.....|| ||..:.:.|:.||.||: |:.|    .::....:.:||....|..:...
  Rat   816 --RKATLVNEADKLRSALACSNEVWILNRYLSY-TLNPDYIRKQDATSTIVSIANNVVGQTLVWD 877

  Fly  1037 FLQAKWFELEKRLGPGTISFAKVISAITQYGATKFDYDELKSLVH---RFGRGHGMSVLNMTLSS 1098
            |:::.|.:|.:..|.|:.|||.:|..:|:..:::|:..:|:....   ..|.|.|...|...|..
  Rat   878 FVRSNWKKLFEDYGGGSFSFANLIQGVTRRFSSEFELQQLEQFKEDNSATGFGSGTRALEQALEK 942

  Fly  1099 VASNVEWVARSQTSLYKWVEGN 1120
            ..:|::||..::..:.||...|
  Rat   943 TKANIKWVKENKDVVLKWFTEN 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4467	NP_001036747.1	GluZincin	145..677	CDD:472708	125/567 (22%)
		ERAP1_C	783..1078	CDD:463368	78/317 (25%)
Anpep	NP_112274.1	Cytosolic Ser/Thr-rich junction	33..68		8/39 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	44..68		5/28 (18%)
		Metalloprotease	69..965		242/1062 (23%)
		M1_APN-Q_like	84..545	CDD:341064	125/566 (22%)
		ERAP1_C	618..945	CDD:463368	83/343 (24%)