Protein Alignment CG4467 and Erap1

DIOPT Version :10

• Sequence 1: NP_001036747.1
• Gene: CG4467 / 42747
• FlyBaseID: FBgn0039064
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: XP_006231762.1
• Gene: Erap1 / 80897
• RGDID: 708542
• Length: 954
• Species: Rattus norvegicus
• Alignment Length: 1104
• Identity: 250/1104 - (22%)
• Similarity: 452/1104 - (40%)
• Gaps: 230/1104 - (20%)

  Fly    83 SLLLTAIIIAYAGPQNDCSCGSKTVSGYETDEENNTQPFNPIATNGEPFPWLEKMLPTSVRPLRY 147
            ||:||  .:|.:.|  .|...|.|.|              |.|:||..|.|....||..:.|:.|
  Rat     6 SLVLT--FLAVSSP--SCCQNSDTAS--------------PKASNGASFLWNNMRLPEYITPIHY 52

  Fly   148 MVTIHPNLTTLDVKGQVTIDLHVEKETNFIVLHIQDLNVTEKAIVTPGPKGYALKIVKVLEFPPR 212
            .:.||.||:||...|:..:::.|.:.|:.|::|...|.:::..:.....:....:.:|::|:...
  Rat    53 DLMIHANLSTLTFWGKTEVEITVSQPTSTIIMHSHQLQISKATLRRGAEEMLPEEPLKLMEYSAH 117

  Fly   213 QQLYIEVKERLKKKSNYTLNLRWYSKLNPEPEGFYVDQYESSNGVERLLAATVFRPNGARRAFPC 277
            :|:.:...:.|...|.||:.:.:.:.|:....|||...|.:..|..|:||||.|.|..||.||||
  Rat   118 EQVALLTAQPLLAGSVYTVIITYAANLSENFHGFYKSTYRTQEGERRILAATQFEPTAARMAFPC 182

  Fly   278 FDEPHVRAPFRISVFRDRFHIGLSNSIVHTTEDVGFYMGTGLLRDDFIETPPLPADAVAWVVSDF 342
            ||||.::|.|.|.:.||..|:.:||..:..:..|    ..||:.|.|..|..:....||:::|||
  Rat   183 FDEPALKASFSIKIKRDPRHLAISNMPLVKSVTV----AEGLIEDHFDITVKMSTYLVAFIISDF 243

  Fly   343 QRESLQPSAAYIPTTPAPPGSGVGGKKSAQLNNYTQLKGKNPPVRNITALTHSLNVNLTPRQNLT 407
            :
  Rat   244 K---------------------------------------------------------------- 244

  Fly   408 VVQPTTTTAWPVNLNGNGKPSNLTSLSQSTGSSIKRAPSYTFYAPRDLLIRSSFILHTSRDVLEY 472
                                    |:|:.|.|.:|    .:.||..|.:.::.:.|..:..:||:
  Rat   245 ------------------------SVSKMTKSGVK----VSVYAVPDKINQADYALDAAVTLLEF 281

  Fly   473 LQTWLDISYPLTKVDFVALPSLDRNMISSLGLVTLKTS-FLTDPSSITSEQYQFSALRIAEAMVR 536
            .:.:..|.|||.|.|..|:|......:.:.||.|.:.| .|.|....::.......:.::..:..
  Rat   282 YEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLYDKEKSSASSKLGITMTVSHELAH 346

  Fly   537 QFFGGITSRKVLKDVWLWEGLIQYLGIHALAPLQETWPLREMYLLKMATA--------------- 586
            |:||.:.:.:...|:||.||..:::   ....:..|.|  |:.::::.||
  Rat   347 QWFGNLVTMEWWNDLWLNEGFAKFM---EFVSVTVTHP--ELKVMQILTANHQNEPEDLSGRAME 406

  Fly   587 -------------ALDIDAIQGWDSIMNGTSHDGNNEEFF----VQKTAAIFSMLHTAIGEDRFR 634
                         |:::||:.....:.....:.....|.|    .:|.|.|.:||...:..|.|:
  Rat   407 RTEEEYFFGKCFNAMEVDALNSSHPVSTPVENPAQIREMFDEVSYEKGACILNMLRDYLSADTFK 471

  Fly   635 GCLGSFLKVNRFRTAEPTDLWT----------------ICTKKANGSK---------NIKDMMTL 674
            ..:..:|:...::..:..|||.                .|::..:.|.         :||.||..
  Rat   472 RGIVQYLQKYSYKNTKNEDLWNSMMHICPTDGTQTMDGFCSRNQHSSSTSHWRQEVIDIKSMMNT 536

  Fly   675 WTHQPGFPLLTVTKMGNSISISQRPFRPAEFLAIHDDSYDGNNYNKTTLNATDMPSTVATTTQGS 739
            ||.|.||||:|:|..|.::.:.|                  .:|.|   .:...|.|      ||
  Rat   537 WTLQKGFPLITITVRGRNVHLKQ------------------EHYMK---GSECFPET------GS 574

  Fly   740 KHKVAPHMKWIFPVTYVTD-INNVSETLWMQNVDVTFNVPENVKWIKVNAIQNGYYRVVYNDDNW 803
                    .|..|:|::|. .::|...|.....||.. :||.|:|||.|...||||.|.|.||.|
  Rat   575 --------LWHVPLTFITSKSDSVQRFLLKTKTDVII-LPEAVEWIKFNVGMNGYYIVHYGDDGW 630

  Fly   804 ASLIEELAANPNRFTSEDRLGMLSDAFTLCHANLLPCEITMNMIQYLPSETHYGPMALALRHLEK 868
            |||...|.......:|.||..::::||.|.....|..|..:::|.||.:||...|:...|..|..
  Rat   631 ASLNGLLKEAHTTISSNDRASLINNAFQLVSIGKLSIEKALDLILYLKNETEIMPIFQGLNELIP 695

  Fly   869 WRRILK---YSECFLMLSEFIKMKISTVMEKVGWSDDGDVATRLLRPEVLLASVLWEDIDSITKA 930
            ..::::   ..|......:|:...:..::.|..|:|:|.|:.|:||.::||.:.:......:.:|
  Rat   696 MYKLMEKRDMVEVETQFKDFLLRLLKDLINKQTWTDEGSVSERMLRSQLLLLACVHRYQLCVQRA 760

  Fly   931 KNMLNQYLYYNGT-AIPPNLREVVYTGSILSGEYIYWQHCWERFVNLQRTSETFVERMQLLRALG 994
            :....::...||. ::|.::...|:.....:.|      .|:...:..::|.:..|:.|:..:|.
  Rat   761 ERYFREWKASNGNMSLPIDVTLAVFAVGAQNTE------GWDFLYSKYQSSLSSTEKSQIEFSLC 819

  Fly   995 RTKD----AWLQNRLLSHVTMLPTEEVVQVLKAIAGTPTGGAMACRFLQAKWFELEKRLGPGTIS 1055
            .::|    .||.::.... .::.|:|...:|..|...|.|..:|.:||:..|.::.::...|:.|
  Rat   820 ISQDPEKLQWLLDQSFKG-EIIKTQEFPHILTLIGRNPVGYPLAWKFLKENWNKIVQKFELGSSS 883

  Fly  1056 FAKVISAITQYGATKFDYDELKSLVHRFGR-GHGMSVLNMTLSSVASNVEWVARSQTSLYKWVE 1118
            .|.::...|...:|:...:|:|.......: |..:..:..|:.::..|:.|:.::...:..|::
  Rat   884 IAHMVMGTTNQFSTRARLEEVKGFFSSLKKNGSQLRCVQQTIETIEENIRWMDKNFDKIRLWLQ 947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4467	NP_001036747.1	GluZincin	145..677	CDD:472708	123/589 (21%)
		ERAP1_C	783..1078	CDD:463368	75/302 (25%)
Erap1	XP_006231762.1	M1_APN-Q_like	50..539	CDD:341064	123/589 (21%)
		ERAP1_C	610..929	CDD:463368	78/325 (24%)