Protein Alignment CG4467 and npepps

DIOPT Version :10

• Sequence 1: NP_001036747.1
• Gene: CG4467 / 42747
• FlyBaseID: FBgn0039064
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: NP_001072690.1
• Gene: npepps / 780147
• XenbaseID: XB-GENE-1008338
• Length: 875
• Species: Xenopus tropicalis
• Alignment Length: 1037
• Identity: 229/1037 - (22%)
• Similarity: 403/1037 - (38%)
• Gaps: 226/1037 - (21%)

  Fly   130 PFPWLEKMLPTSVRPLRYMVTIHPNLTTLDVKGQVTIDLHVEKETNFIVLHIQDLNVTEKAIVTP 194
            ||    :.|||.|||:.|.:.:.|:|.....:|::...:.|:..||.||::..|:::...:....
 Frog     6 PF----ERLPTDVRPVNYGLCLKPDLIDFTFEGKLEATVEVQNATNQIVMNCADIDIITASYAPE 66

  Fly   195 GPK-------GYALKIVKV-LEFPPRQQLYIEVKERLKKKSNYTLNLRWYSKLNPEPEGFYVDQY 251
            |.:       .|..:..|| |.||...|           |....|.:.:..:||.:.:|||..:|
 Frog    67 GDEEIHATGFNYQNEDEKVTLSFPSTLQ-----------KGAGMLKIDFVGELNDKMKGFYRSKY 120

  Fly   252 ESSNGVERLLAATVFRPNGARRAFPCFDEPHVRAPFRISVFRDRFHIGLSNSIVHTTEDVGFYMG 316
            .::.|..|..|.|.|....|||||||:|||.::|.|.:.:...:..:.|||  ::..:...:...
 Frog   121 ATATGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDVILIVPKDRVALSN--MNLIDRKPYPDD 183

  Fly   317 TGLLRDDFIETPPLPADAVAWVVSDFQRESLQPSAAYIPTTPAPPGSGVGGKKSAQLNNYTQLKG 381
            ..|:...|..||.:....||:||.::.....:.|...:.....|.|....||
 Frog   184 ENLVEVKFARTPIMSTYLVAFVVGEYDFVETRSSDGVLVRVYTPVGKAEQGK------------- 235

  Fly   382 KNPPVRNITALTHSLNVNLTPRQNLTVVQPTTTTAWPVNLNGNGKPSNLTSLSQSTGSSIKRAPS 446
                                                                             
 Frog   236 ----------------------------------------------------------------- 235

  Fly   447 YTFYAPRDLLIRSSFILHTSRDVLEYLQTWLDISYPLTKVDFVALPSLDRNMISSLGLVTLK-TS 510
                          |.|..:...|.:.:.:.::.|||.|:|.:|:.......:.:.||||.: |:
 Frog   236 --------------FALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETA 286

  Fly   511 FLTDPSSITSEQYQFSALRIAEAMVRQFFGGITSRKVLKDVWLWEGL---IQYLGIHALAPLQET 572
            .|.||.:..|...|:.||.:...:..|:||.:.:.:....:||.||.   |:||.:....|..:.
 Frog   287 LLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDI 351

  Fly   573 WPLREMYLLKMATAALDIDAIQGWDSIMNGTSHDGNNEEFF----VQKTAAIFSMLHTAIGEDRF 633
            |   ..::....|.|.::||::....|.....|....:|.|    ..|.|::..|||..||::.|
 Frog   352 W---TQFVSADYTRAQELDALENSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDEDF 413

  Fly   634 RGCLGSFLKVNRFRTAEPTDLWTICTKKANGSKNIKDMMTLWTHQPGFPLLTVTKMGNS----IS 694
            |..:..:|...:.:.|...|||. ..::|:| |.|..:|..||.|.||||:.|......    :.
 Frog   414 RKGMNQYLTKFQEKNAATEDLWE-SLEQASG-KPIAAVMNTWTKQMGFPLICVESEQKEDSVVLK 476

  Fly   695 ISQRPFRPAEFLAIHDDSYDGNNYNKTTLNATDMPSTVATTTQGSKHKVAPHMKWIFPVTYVTDI 759
            :||:.| .|......||||                                  :|:.|::..|..
 Frog   477 LSQKKF-CASGAPNSDDSY----------------------------------QWMVPISICTSE 506

  Fly   760 NNVSET--LWMQNVDVTFNVPENVK---WIKVNAIQNGYYRVVYNDDNWASL---IEELAANPNR 816
            :..|.|  :.|...::|. |.|.||   |:|:|....|:||..|:.....||   |.:|:..|
 Frog   507 SPASATVKILMDKPEMTV-VLEGVKPHQWVKLNPGTVGFYRTQYSTTMLESLLPGIRDLSLQP-- 568

  Fly   817 FTSEDRLGMLSDAFTLCHANLLPCEITMNMIQYLPSETHY----------GPMALALRHLEKWRR 871
               .||||:.:|.|:|..|.::.....:.:::...:|.:|          |.::..|.|.:....
 Frog   569 ---VDRLGLQNDLFSLARAGMINTAEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFHEE 630

  Fly   872 ILKYSECFLMLSEFIKMKISTVMEKVGWS---DDGDVATRLLRPEVLLASVLWEDIDSITKAKNM 933
            |    :|      |::...|.:.:::||.   .:|.: ..|||..||..........::.:|:..
 Frog   631 I----QC------FVRDVFSPIGQRLGWDPKPGEGHL-DALLRGLVLGKLGKAGHQPTLEEARRR 684

  Fly   934 LNQYLYYNG-TAIPPNLREVVYTGSILSGEYIYWQHCWERFVNLQRTSETFVERMQLLRALGRTK 997
            ..:::  :| ..:..:||..||...:..|:    ....|..:.|.:.::...|:.::.|.||...
 Frog   685 FKEHV--DGRNVLSADLRSPVYVTVLKHGD----NSTLETMMKLHKQADMQEEKNRIERVLGAIA 743

  Fly   998 DAWLQNRLLSHVTM--LPTEEVVQVLKAIA-GTPTGGAMACRFLQAKWFELEKRLGPGTISFAKV 1059
            :..|..::||....  :..::.|.|:..:| |:..|...|..|::..|.||..|...|.:
 Frog   744 EQDLIKKVLSFSLSEDVRPQDTVCVIGGVAGGSKLGRKCAWNFVKDNWEELYNRYQGGFL----- 803

  Fly  1060 ISAITQYGATKFDYDELKSLVHRFGRGHGMSVLNMTLSSVASNV----EWVARSQTSLYKWV 1117
            ||.:.:.....|..|::.:.:..|...|.......|:.....|:    .|:.|...:::.::
 Frog   804 ISRLIKLSLDGFASDKMAAEIKAFFDAHPAPSAERTVQQCCENILLNAGWLKRDAEAIHHYL 865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4467	NP_001036747.1	GluZincin	145..677	CDD:472708	120/547 (22%)
		ERAP1_C	783..1078	CDD:463368	69/314 (22%)
npepps	NP_001072690.1	M1_APN-Q_like	17..455	CDD:341064	120/547 (22%)
		ERAP1_C	534..847	CDD:463368	72/339 (21%)