Protein Alignment CG4467 and Lvrn

DIOPT Version :10

• Sequence 1: NP_001036747.1
• Gene: CG4467 / 42747
• FlyBaseID: FBgn0039064
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: NP_083284.1
• Gene: Lvrn / 74574
• MGIID: 1921824
• Length: 991
• Species: Mus musculus
• Alignment Length: 1156
• Identity: 247/1156 - (21%)
• Similarity: 435/1156 - (37%)
• Gaps: 273/1156 - (23%)

  Fly    59 RQTRTGVAVCSQRRALLVAGIVLGSLLLTAIIIAYAGPQNDCSCGSKTVSGYETDEENNTQPFNP 123
            |...:||.| |:..|||:|.:   :.:|..:::|.|.....|:....:..|  .....||..:.|
Mouse     3 RPFSSGVYV-SRGVALLLAAL---TAVLLLVLVALASLYGSCAHVQPSEQG--NSRVKNTSLWPP 61

  Fly   124 ---------------IATN---GEPF-PWLEKMLPTSVRPLRYMVTI----------HPNLTTLD 159
                           :.|:   |.|. ||....||..:.||.|.:.:          .||||
Mouse    62 GGQEWALPTPAQEPTVGTSQDLGPPSGPWDHLRLPPWLVPLHYDLELWPWLQPDKLSPPNLT--- 123

  Fly   160 VKGQVTIDLHVEKETNFIVLHIQDLNVTEKAIVTPGPKGY--------ALKIVKVLEFPPRQQLY 216
            ..|:|.|.:.....::.::||...||.  |.:...||...        .:::.||...|..|.:.
Mouse   124 FTGRVNITVRCTVASSRLLLHSFLLNY--KQVEVWGPLAQDTRNATVGRVQVEKVWFAPDMQFVV 186

  Fly   217 IEVKERLKKKSNYTLNLRWYSK-LNPEPEGFYVDQYESSNGVERLLAATVFRPNGARRAFPCFDE 280
            :::.:.|:..|.|.|:..:..: |....||.:::.|...:.: |.|.||...|..||..||||||
Mouse   187 LDLGQSLEPGSRYELSFHFSGQVLQVGLEGLFLNLYHDEDEL-RALVATQMEPTFARHVFPCFDE 250

  Fly   281 PHVRAPFRISVFRDRFHIGLSNSIVHTTEDVGFYMGTGLLRDDFIETPPLPADAVAWVVSDFQRE 345
            |.::|.|.|:|.....:..|||     ...:|             ::..:..:...|.|:.|
Mouse   251 PALKATFNITVIHHPGYAALSN-----MPQLG-------------QSERIDVNGSRWTVTTF--- 294

  Fly   346 SLQPSAAYIPTTPAPPGSGVGGKKSAQLNNYTQLKGKNPPVRNITALTHSLNVNLTPRQNLTVVQ 410
                                                                 :.|||      .
Mouse   295 -----------------------------------------------------HTTPR------M 300

  Fly   411 PTTTTAWPVNLNGNGKPSNLTSLSQSTGSSIKRAPSYTFYAPRDLLIRS--SFILHTSRDVLEYL 473
            ||...|..|        .:|..:|::     :|......:|.:|.:...  .|..:.:..:..:|
Mouse   301 PTYLVALVV--------CDLDHISRT-----ERGKEIRVWARKDDIASGYLDFAANITGPIFSFL 352

  Fly   474 QTWLDISYPLTKVDFVALPSLDRNMISSLGLVTL-KTSFLTDPSSITSEQYQFSALRIAEAMVRQ 537
            :...:|||.|.|.|.||||......:.:.||:.. ::|.|.:|....:|:.......||..:..|
Mouse   353 EDLFNISYRLPKTDIVALPIFASGAMENWGLLIFDESSLLLEPEDELTEKRAMILSIIAHEVGHQ 417

  Fly   538 FFGGITSRKVLKDVWLWEGLIQYLGIHALAPLQETWPLREMYLLKMATA------ALDIDAIQGW 596
            :||.:.:.....::||.||...|..:..........|:..::...:...      ||:..|:.
Mouse   418 WFGNLVTMSWWNNIWLNEGFASYFELELTNYFYPKVPMNMIFFFTVLHGILGEDHALESRAVS-- 480

  Fly   597 DSIMNGTSHDGNNEEFFV---QKTAAIFSMLHTAIGEDRFRGCLGSFLKVNRFRTAEPTDLWTIC 658
            .::.|.|.....|..|.:   :|.|.:..||.:.:....|...|.|:|:...:..||..|||. .
Mouse   481 TAVENFTETSEINRLFDLYTYKKGACMAWMLASFLSPHLFINALKSYLETFSYSNAEQDDLWR-H 544

  Fly   659 TKKANGSKN-------IKDMMTLWTHQPGFPLLTVTKMGNSIS---ISQRPFRPAEFLAIHDDSY 713
            .:.|.|.:|       :|.:|..|||:.|||::||     ::|   :.|.||            |
Mouse   545 IQMAIGEQNVTHLPATVKGIMDSWTHRGGFPIITV-----NVSTGVVKQEPF------------Y 592

  Fly   714 DGNNYNKTTL--NATDMPSTVATTTQGSKHKVAPHMKWIFPVTYVTDINNVSETL-WMQNVDVTF 775
            .....|:|.|  |:|                      ||.|:.::.  |.:.:.| |:...::.|
Mouse   593 LDKVENQTLLSHNST----------------------WIVPIFWMK--NGIPQPLVWLDKSNMMF 633

  Fly   776 NVP------ENVKWIKVNAIQNGYYRVVYNDDNWASLIEELAANPNRFTSEDRLGMLSDAFTLCH 834
              |      .:..|:.:|....|||||.|::..|..|.|:|..:|......:||.::||||.|..
Mouse   634 --PGMKLSDSDSDWVILNFNVTGYYRVNYDELGWKKLSEQLEKDPKAIPVINRLQLVSDAFALTK 696

  Fly   835 ANLLPCEITMNMIQYLPSETH-----------------YGPMALALRHLEKWRRILKYSECFLML 882
            .|.:..|..:::.:|:..|..                 |.....||..|.|...:.:::..:...
Mouse   697 NNYIEIETALDLTKYIAEEDEILVWFEVLLNLINREVIYDVNNYALYPLLKKYLLKRFNSIWNTY 761

  Fly   883 SEFIKMKISTVMEKVGWSDDGDVATRLLRPEVLLASVLWEDI-DSITKAKNMLNQYLYYNGTAIP 946
            |..|:..::::.         |....|...|.:..:..|..: |.:..::.:..::..:..||||
Mouse   762 SAIIRENVASLQ---------DNYLSLFSLERIFETACWLGLEDCLQLSRELFKKWTAHPETAIP 817

  Fly   947 PNLREVVYTGSILSGEYIYWQHCWERFVNLQRTSETFVE--RMQLLRALGRTKDAWLQNRLLSH- 1008
            |.:...|...::..|....|...:..::|   |:|...|  |.:|:.|:..:||.|:.||.:.:
Mouse   818 PQIENAVLCSAVALGSDKDWDFLFNLYIN---TTEEEDESRRRRLVHAMSCSKDPWILNRFMEYA 879

  Fly  1009 VTMLPTE-EVVQVLKAIAGTPTGGAMACRFLQAKWFELEKRLGPGTISFAKVISAITQYGATKFD 1072
            :|.:.:. ....::..:|.:..|..:|..||...|..:.:|.|...:.     :.:...|.|...
Mouse   880 ITAVSSNFSETNIIVVVATSEVGRYIAKDFLMDNWVAVTERYGMDWLD-----ALVPVLGRTVST 939

  Fly  1073 YDELKSLVHRFG---RGHGMSVLNMTLSS-----------VASNVEWVARS 1109
            ..::..|.|.|.   ..|...|:...|.:           :|..|||:.::
Mouse   940 DQQVTELQHFFSTVLEEHQRVVVQAKLQAMKTKNLQNKKRIARVVEWLRKN 990

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4467	NP_001036747.1	GluZincin	145..677	CDD:472708	120/569 (21%)
		ERAP1_C	783..1078	CDD:463368	67/316 (21%)
Lvrn	NP_083284.1	M1_APN-Q_like	102..570	CDD:341064	120/569 (21%)
		ERAP1_C	645..964	CDD:463368	72/335 (21%)