Protein Alignment CG4467 and Enpep

DIOPT Version :10

• Sequence 1: NP_001036747.1
• Gene: CG4467 / 42747
• FlyBaseID: FBgn0039064
• Length: 1125
• Species: Drosophila melanogaster
• Sequence 2: NP_071587.2
• Gene: Enpep / 64017
• RGDID: 621228
• Length: 945
• Species: Rattus norvegicus
• Alignment Length: 1095
• Identity: 252/1095 - (23%)
• Similarity: 447/1095 - (40%)
• Gaps: 232/1095 - (21%)

  Fly    79 IVLGSLLLTAIIIAYA-GPQNDCSCGSKTVSGYETDEENNTQPFNPIA-----------TNGEPF 131
            |:..:::...:|:..: |....|..|:       |...:|..|....|           ::.|..
  Rat    21 IICATVVAVGLIVGLSVGLTRSCEPGT-------TPAPSNPPPHTSTALPPQDQNVCPDSDDESG 78

  Fly   132 PWLEKMLPTSVRPLRYMVTIHPNLTTLDVKGQVTIDLHVEKETNFIVLHIQDLNVTEKAIVTPGP 196
            .|....||..::|:.|.:.:...:......|.|:|.:::.|:|..:.|||::..:| |......|
  Rat    79 EWKNFRLPDFIQPVHYDLEVKVLMEEDRYTGIVSISVNLSKDTRDLWLHIRETRIT-KLPELRRP 142

  Fly   197 KGYALKIVKVLEFPPRQQLYIEVKERLKKKSN---YTLNLRWYSKLNPEPEGFYVDQYESSNGVE 258
            .|..:.|.:..|:..::.:.|:.:|.|...|.   |.|.:.:...||....|||...| :.:|..
  Rat   143 SGEQVPIRRCFEYKKQEYVVIQAEEDLAATSGDSVYRLTIEFEGWLNGSLVGFYRTTY-TEDGQT 206

  Fly   259 RLLAATVFRPNGARRAFPCFDEPHVRAPFRISVFRDRFHIGLSNSIVHTTEDVGFYMGTGLLRDD 323
            :.:|||...|..||::|||||||:.:|.:.||:...:.:..|||..|...|.    :.....:..
  Rat   207 KSIAATDHEPTDARKSFPCFDEPNKKATYNISLIHPKEYSALSNMPVEKEET----LDNDWKKTT 267

  Fly   324 FIETPPLPADAVAWVVSDFQRESLQPSAAYIPTTPAPPGSGVGGKKSAQLNNYTQLKGKNPPVRN 388
            |:::.|:....|.:.|..|
  Rat   268 FMKSVPMSTYLVCFAVHQF---------------------------------------------- 286

  Fly   389 ITALTHSLNVNLTPRQNLTVVQPTTTTAWPVNLNGNGKPSNLTSLSQSTGSSIKRAPSYTFYAPR 453
                              |.:|.|:.         :|||                   .|.|...
  Rat   287 ------------------TSIQRTSR---------SGKP-------------------LTVYVQP 305

  Fly   454 DLLIRSSFILHTSRDVLEYLQTWLDISYPLTKVDFVALPSLDRNMISSLGLVTLK-TSFLTDPSS 517
            :....:.:..:.::.|.::.:.:..:.|.|.|:|.:|:|......:.:.||||.: |:.|.||..
  Rat   306 NQKQTAEYAANITKAVFDFFEDYFAMEYSLPKLDKIAIPDFGTGAMENWGLVTYRETNLLYDPLL 370

  Fly   518 ITSEQYQFSALRIAEAMVRQFFGGITSRKVLKDVWLWEG---LIQYLGI-HALAPLQETWPLREM 578
            ..|...|..|..:|..:|.|:||.|.:.....|:||.||   ..::||: ||    :..|.:...
  Rat   371 SASSNQQRVASVVAHELVHQWFGNIVTMDWWDDLWLNEGFASFFEFLGVNHA----EADWQMLSQ 431

  Fly   579 YLLKMATAALDIDAIQGWDSIMNGTSH----------------DGNNEEFFVQKTAAIFSMLHTA 627
            .||:      |:..:|..||:|  :||                ||    ....|.|:|..||...
  Rat   432 VLLE------DVLPVQEDDSLM--SSHPVVVTVSTPAEITSVFDG----ISYSKGASILRMLQDW 484

  Fly   628 IGEDRF-RGCLGSFLKVNRFRTAEPTDLWTICTKKANGSKNIKDMMTLWTHQPGFPLLTVTKMGN 691
            |..::| :|| ..:|:..:|:.|:.:|.|....|.:|  :.:|::|..||.|.|:|::||:...|
  Rat   485 ITPEKFQKGC-QIYLENFKFKNAKTSDFWDSLEKASN--QPVKEVMDTWTSQMGYPVVTVSGKQN 546

  Fly   692 SISISQRPFRPAEFLAIHDDSYDGNNYNKTTLNATDMPSTVATTTQGSKHKVAPHMKWIFPVTYV 756
               ::|:.|       :.|...|          .:..||.:..|             |..|:.:.
  Rat   547 ---VTQKRF-------LLDYKAD----------PSQPPSALGYT-------------WNIPIKWT 578

  Fly   757 TDINNVSETLWMQNVD-VTFNVPENVK---WIKVNAIQNGYYRVVYNDDNWASLIEELAANPNRF 817
            .:.|:.....:..|.: :|.|.  |:.   ::|:|....|:|||.|..:.|..:.|.|::|...|
  Rat   579 ENGNSNITVYYRSNREGITLNA--NLSGDGFLKINPDHIGFYRVNYEAETWDWIAETLSSNHMNF 641

  Fly   818 TSEDRLGMLSDAFTLCHANLLPCEITMNMIQYLPSETHYGPMALALRHLEKWRRILKY------- 875
            :|.||...:.|||.|..|.||..|..:|:.:||.||..:.|          |.|::..
  Rat   642 SSADRSSFIDDAFALARAQLLDYEKALNLTRYLTSEKDFLP----------WERVISAVSYIISM 696

  Fly   876 ----SECFLMLSEFIKMKISTVMEKVGWSDDGDVATRLLRPEVLLASVLWEDIDSITKAKNMLNQ 936
                .|.:.::..:.:.::..:.:.:||.|.|...|:|||..||..:......:::..|..:...
  Rat   697 FEDDRELYPLIETYFRSQVKPIADSLGWQDTGSHITKLLRASVLGFACKMGAGEALGNASQLFEA 761

  Fly   937 YLYYNGTAIPPNLREVVYT-GSILSGEYIYWQHCWERFVNLQRTSETFVERMQLLRALGRTKDAW 1000
            :|..| .:||.|||.:||. |...||....|.:..|::   |:|| ...|:.:||..|...||..
  Rat   762 WLKGN-ESIPVNLRLLVYRYGMQNSGNEAAWNYTLEQY---QKTS-LAQEKEKLLYGLASVKDVT 821

  Fly  1001 LQNR---LLSHVTMLPTEEVVQVLKAIAGTPTGGAMACRFLQAKWFELEKRLGPGTISFAKVISA 1062
            |..|   :|....::.|::|..|::.|:....|.:||..::|..|..|..|.........::::.
  Rat   822 LLARYLEMLKDPNIIKTQDVFTVIRYISYNSYGKSMAWNWIQLNWDYLVNRFTINDRYLGRIVTI 886

  Fly  1063 ITQYGATKFDYDELKSLVHRF-GRGHGMSVLNMTLSSVASNVEWVARSQTSLYKW 1116
            ...:. |:....:::|...:: ..|.|.......|.:|.:|:||:..::.|:.:|
  Rat   887 AEPFN-TELQLWQMQSFFAKYPNAGAGAKPREQVLETVKNNIEWLKLNRKSISEW 940

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4467	NP_001036747.1	GluZincin	145..677	CDD:472708	126/556 (23%)
		ERAP1_C	783..1078	CDD:463368	81/309 (26%)
Enpep	NP_071587.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	45..77		5/38 (13%)
		M1_APN-Q_like	92..531	CDD:341064	125/555 (23%)
		ERAP1_C	607..925	CDD:463368	86/333 (26%)